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Nr1h4 Gene Detail
Summary
  • Symbol
    Nr1h4
  • Name
    nuclear receptor subfamily 1, group H, member 4
  • Synonyms
    Fxr, FXR, HRR1, RIP14, Rxrip14
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352464
    NCBI Gene: 20186
Location & Maps
more
  • Sequence Map
    Chr10:89454234-89533585 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      79352 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NR1H4, nuclear receptor subfamily 1 group H member 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NR1H4, nuclear receptor subfamily 1 group H member 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BAR, FXR, HRR1, HRR-1, RIP14
  • Links
    NCBI Gene ID: 9971
    neXtProt AC: NX_Q96RI1

  • Chr Location
    12q23.1; chr12:100473759-100563867 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3760
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: NR1H4
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Nr1h4 mouse models

Human Disease Mouse Models
       Hepatocellular Carcinoma   OMIM: 114550 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    56 phenotypes from 4 alleles in 8 genetic backgrounds
    4 phenotypes from multigenic genotypes
    2 images
    116 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Targeted
    10
  • Transposon induced
    1
  • Genomic Mutations
    2 involving Nr1h4
  • Incidental Mutations
Mice homozygous for knock-out alleles exhibit increased bile salts and abnormal liver morphology and physiology. Mice homozygous for one knock-out allele also exhibit abnormal lipid homeostasis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022710 VEGA Gene Model | MGI Sequence Detail 79352 C57BL/6J ±  kb
transcript OTTMUST00000054480 VEGA | MGI Sequence Detail 1964 Not Applicable  
polypeptide OTTMUSP00000026009 VEGA | MGI Sequence Detail 484 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    507 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000011396 bile acid receptor
  • InterPro Domains
    IPR001723 Nuclear hormone receptor
    IPR000536 Nuclear hormone receptor, ligand-binding domain
    IPR001728 Thyroid hormone receptor
    IPR013088 Zinc finger, NHR/GATA-type
    IPR001628 Zinc finger, nuclear hormone receptor-type
Molecular
Reagents
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  • All nucleic 39
    cDNA 38
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-24051, MGD-MRK-33613, MGI:103183, MGI:105934, MGI:2143705
References
more
  • Summaries
    All 176
    Developmental Gene Expression 14
    Diseases 3
    Gene Ontology 17
    Phenotypes 116
  • Earliest
    J:23077 Seol W, et al., Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors. Mol Endocrinol. 1995 Jan;9(1):72-85
  • Latest
    J:224384 Trabelsi MS, et al., Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells. Nat Commun. 2015;6:7629

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory