Nr1h4
Gene Detail

Symbol Name ID

Nr1h4 nuclear receptor subfamily 1, group H, member 4 MGI:1352464

Synonyms

Fxr, FXR, HRR1, RIP14, Rxrip14

Feature Type

protein coding gene

Genetic Map

Chromosome 10

44.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr10:89454234-89533585 bp, - strand From VEGA annotation of GRCm38   79352 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3760  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Nr1h4

Human homologs

Human Homolog		NR1H4, nuclear receptor subfamily 1, group H, member 4
NCBI Gene ID		9971
neXtProt AC		NX_Q96RI1
Human Synonyms		BAR, FXR, HRR1, HRR-1, RIP14
Human Chr (Location)		12q23.1; chr12:100867551-100957645 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(9) : Targeted(9)
 

Mice homozygous for knock-out alleles exhibit increased bile salts and abnormal liver morphology and physiology. Mice homozygous for one knock-out allele also exhibit abnormal lipid homeostasis.

 
Human Diseases Modeled Using Mouse Nr1h4 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (40 annotations)

Process	bile acid metabolic process, cellular response to acid, ...
Component	nuclear euchromatin, nucleus
Function	bile acid binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (319)    Tissues (213)    Images (6)
Theiler Stages: 17, 19, 21, 22, 23, 28

Assay Type	Results
RNA in situ	319

cDNA source data(37)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(39) cDNA(38) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000022710 (Evidence)
Ensembl Gene Model	ENSMUSG00000047638 (Evidence)
Entrez Gene	20186 (Evidence)
UniGene	3095
DFCI	TC1582434, TC1608395, TC1656845, TC1659806
DoTS	DT.490919, DT.91338634, DT.94201152
NIA Mouse Gene Index	U032117
Consensus CDS Project	CCDS24116.1, CCDS48668.1, CCDS48669.1
International Mouse Knockout Project Status	Nr1h4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022710	VEGA Gene Model | MGI Sequence Detail	79352	C57BL/6J
transcript	OTTMUST00000054480	VEGA | MGI Sequence Detail	1964	Not Applicable
polypeptide	OTTMUSP00000026009	VEGA | MGI Sequence Detail	484	Not Applicable

All sequences(37) RefSeq(6) UniProt(3)

Polymorphisms

RFLP(2) : SNPs(194 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008946	Nuclear hormone receptor, ligand-binding
InterPro	IPR000536	Nuclear hormone receptor, ligand-binding, core
InterPro	IPR001723	Steroid hormone receptor
InterPro	IPR001728	Thyroid hormone receptor
InterPro	IPR013088	Zinc finger, NHR/GATA-type
InterPro	IPR001628	Zinc finger, nuclear hormone receptor-type
Protein Ontology	PR:000011396	bile acid receptor

References

(Earliest) J:23077 Seol W, et al., Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors. Mol Endocrinol. 1995 Jan;9(1):72-85
(Latest) J:194178 Shimizu M, et al., FGF19 (fibroblast growth factor 19) as a novel target gene for activating transcription factor 4 in response to endoplasmic reticulum stress. Biochem J. 2013 Feb 15;450(1):221-9
All references(146)

Other accession IDs

MGD-MRK-24051, MGD-MRK-33613, MGI:103183, MGI:105934, MGI:2143705