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Nr1h4
Gene Detail
 Symbol
Name
ID
Nr1h4
nuclear receptor subfamily 1, group H, member 4
MGI:1352464
Synonyms Fxr, FXR, HRR1, RIP14, Rxrip14
Feature Type protein coding gene
Genetic Map
Chromosome 10
44.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr10:89454234-89533585 bp, - strand
From VEGA annotation of GRCm38

  79352 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3760  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Nr1h4

Human
homologs
Human Homolog NR1H4, nuclear receptor subfamily 1, group H, member 4
NCBI Gene ID 9971
neXtProt AC  NX_Q96RI1
Human Synonyms  BAR, FXR, HRR1, HRR-1, RIP14
Human Chr (Location)  12q23.1; chr12:100473708-100563867 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for knock-out alleles exhibit increased bile salts and abnormal liver morphology and physiology. Mice homozygous for one knock-out allele also exhibit abnormal lipid homeostasis.
 
Human Diseases Modeled Using Mouse Nr1h4 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Nr1h4 interacts with 76 markers (Mir10b, Mir18, Mir101a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (48 annotations)
Process bile acid metabolic process, cellular response to acid chemical, ...
Component nuclear euchromatin, nucleus
Function bile acid binding, bile acid receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (319)    Tissues (213)    Images (6)
Theiler Stages: 17, 19, 21, 22, 23, 27, 28
Assay TypeResults
RNA in situ 319
cDNA source data(37)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) cDNA(38) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000022710 (Evidence)
Ensembl Gene ModelENSMUSG00000047638 (Evidence)
Entrez Gene20186 (Evidence)
UniGene3095
DFCITC1582434, TC1608395, TC1656845, TC1659806
DoTSDT.490919, DT.91338634, DT.94201152
NIA Mouse Gene IndexU032117
Consensus CDS ProjectCCDS24116.1, CCDS48668.1, CCDS48669.1
International Mouse Knockout Project StatusNr1h4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022710 VEGA Gene Model | MGI Sequence Detail 79352 C57BL/6J ±  kb
transcript OTTMUST00000054480 VEGA | MGI Sequence Detail 1964 Not Applicable 
polypeptide OTTMUSP00000026009 VEGA | MGI Sequence Detail 484 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(12) UniProt(3)
Polymorphisms RFLP(2) : SNPs within 2kb(507 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR001723 Steroid hormone receptor
InterPro IPR001728 Thyroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000011396 bile acid receptor
References (Earliest) J:23077 Seol W, et al., Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors. Mol Endocrinol. 1995 Jan;9(1):72-85
(Latest) J:211881 Peng X, et al., Activation of farnesoid X receptor induces RECK expression in mouse liver. Biochem Biophys Res Commun. 2014 Jan 3;443(1):211-6
All references(166)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-24051, MGD-MRK-33613, MGI:103183, MGI:105934, MGI:2143705

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory