Symbol
Name
ID

Nr1h4
nuclear receptor subfamily 1, group H, member 4
MGI:1352464

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Conjugated hyperbilirubinemia	Hyperammonemia	Elevated circulating alpha-fetoprotein concentration	Elevated circulating alanine aminotransferase concentration	Elevated circulating aspartate aminotransferase concentration	Hypoglycemia	Nonimmune hydrops fetalis	Pleural effusion	Ascites
Disease(s) Associated with NR1H4
progressive familial intrahepatic cholestasis 5

Mouse Phenotypes

homeostasis/metabolism phenotype

abnormal blood homeostasis

increased circulating bilirubin level

decreased circulating glucose level

decreased circulating insulin level

increased circulating cholesterol level

decreased circulating free fatty acids level

increased circulating phospholipid level

increased circulating triglyceride level

increased circulating alanine transaminase level

increased circulating aspartate transaminase level

decreased body temperature

increased energy expenditure

impaired glucose tolerance

abnormal bile salt homeostasis

abnormal bile salt level

increased bile salt level

increased liver cholesterol level

increased liver triglyceride level

Availability

Mouse Genotype

Nr1h4^tm1.1Mbj/Nr1h4^tm1.1Mbj

Nr1h4^tm1.2Auw/Nr1h4^tm1.2Auw

Nr1h4^tm1Gonz/Nr1h4^tm1Gonz

Nr1h4^tm1Kok/Nr1h4^tm1Kok

Nr1h4^tm1.1Gonz/Nr1h4^tm1.1Gonz
Tg(Vil1-cre)997Gum/0 (conditional)

Nr1h4^tm1.1Gonz/Nr1h4^tm1.1Gonz
Tg(Alb1-cre)1Dlr/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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