Nr1h2
Gene Detail

Symbol Name ID

Nr1h2 nuclear receptor subfamily 1, group H, member 2 MGI:1352463

Synonyms

LXRB, LXRbeta, RIP15, Unr2

Feature Type

protein coding gene

Genetic Map

Chromosome 7

28.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr7:44549616-44553951 bp, - strand From VEGA annotation of GRCm38   4336 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21397  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Nr1h2

Human homologs

Human Homolog		NR1H2, nuclear receptor subfamily 1, group H, member 2
NCBI Gene ID		7376
neXtProt AC		NX_P55055
Human Synonyms		LXR-b, LXRB, NER, NER-I, RIP15, UNR
Human Chr (Location)		19q13.3; chr19:50879680-50886285 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(9) : Targeted(6) Gene trapped(3)
 

Homozygous null mutations cause altered lipid, cholesterol and glucose metabolism and may lead to elevated cartilage matrix catabolism and PGE2 production, lipid-laden uterus myocytes and Sertoli cells, impaired uterus contractility and parturition, and higher susceptibility to bacterial infection.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (45 annotations)

Process	cellular lipid metabolic process, cholesterol homeostasis, ...
Component	cytoplasm, nucleus
Function	DNA binding, ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (13 records)
Data Summary: Results (81)    Tissues (66)    Images (16)
Theiler Stages: 2, 3, 4, 5, 17, 18, 19, 21, 23, 28

Assay Type	Results
RNA in situ	66
RT-PCR	15

cDNA source data(135)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(137) cDNA(136) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000023074 (Evidence)
Ensembl Gene Model	ENSMUSG00000060601 (Evidence)
Entrez Gene	22260 (Evidence)
UniGene	968
DFCI	TC1574842, TC1584962
DoTS	DT.493838
NIA Mouse Gene Index	U134659
Consensus CDS Project	CCDS21211.1
International Mouse Knockout Project Status	Nr1h2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023074	VEGA Gene Model | MGI Sequence Detail	4336	C57BL/6J
transcript	OTTMUST00000055715	VEGA | MGI Sequence Detail	1839	Not Applicable
polypeptide	OTTMUSP00000026720	VEGA | MGI Sequence Detail	446	Not Applicable

All sequences(58) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(61 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023257	Liver X receptor
InterPro	IPR008946	Nuclear hormone receptor, ligand-binding
InterPro	IPR000536	Nuclear hormone receptor, ligand-binding, core
InterPro	IPR001723	Steroid hormone receptor
InterPro	IPR013088	Zinc finger, NHR/GATA-type
InterPro	IPR001628	Zinc finger, nuclear hormone receptor-type
Protein Ontology	PR:000011394	oxysterols receptor LXR-beta

References

(Earliest) J:23077 Seol W, et al., Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors. Mol Endocrinol. 1995 Jan;9(1):72-85
(Latest) J:193769 Robertson Remen KM, et al., Activation of the liver X receptor-beta potently inhibits osteoclastogenesis from lipopolysaccharide-exposed bone marrow-derived macrophages. J Leukoc Biol. 2013 Jan;93(1):71-82
All references(154)

Other accession IDs

MGD-MRK-24047, MGI:103179, MGI:2141876