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Nr1h2 Gene Detail
Summary
  • Symbol
    Nr1h2
  • Name
    nuclear receptor subfamily 1, group H, member 2
  • Synonyms
    LXRB, LXRbeta, RIP15, Unr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352463
    NCBI Gene: 22260
  • Gene Overview
    MyGene.info: NR1H2
Location & Maps
more
  • Sequence Map
    Chr7:44549616-44553951 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4336 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 28.83 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    NR1H2, nuclear receptor subfamily 1 group H member 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    NR1H2, nuclear receptor subfamily 1 group H member 2
    Orthology source: HomoloGene
  • Synonyms
    LXR-b, LXRB, NER, NER-I, RIP15, UNR
  • Links
    NCBI Gene ID: 7376
    neXtProt AC: NX_P55055

  • Chr Location
    19q13.3; chr19:50376423-50383028 (+)  GRCh38.p2

Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 5 alleles in 6 genetic backgrounds
    50 phenotypes from multigenic genotypes
    112 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Gene trapped
    3
  • Targeted
    6
  • Incidental Mutations
Homozygous null mutations cause altered lipid, cholesterol and glucose metabolism and may lead to elevated cartilage matrix catabolism and PGE2 production, lipid-laden uterus myocytes and Sertoli cells, impaired uterus contractility and parturition, and higher susceptibility to bacterial infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023074 VEGA Gene Model | MGI Sequence Detail 4336 C57BL/6J ±  kb
transcript OTTMUST00000055715 VEGA | MGI Sequence Detail 1839 Not Applicable  
polypeptide OTTMUSP00000026720 VEGA | MGI Sequence Detail 446 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    80 from dbSNP Build 142
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000011394 oxysterols receptor LXR-beta
  • InterPro Domains
    IPR023257 Liver X receptor
    IPR001723 Nuclear hormone receptor
    IPR000536 Nuclear hormone receptor, ligand-binding domain
    IPR013088 Zinc finger, NHR/GATA-type
    IPR001628 Zinc finger, nuclear hormone receptor-type
Molecular
Reagents
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  • All nucleic 137
    cDNA 136
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-24047, MGI:103179, MGI:2141876
References
more
  • Summaries
    All 176
    Developmental Gene Expression 13
    Diseases 1
    Gene Ontology 14
    Phenotypes 112
  • Earliest
    J:23077 Seol W, et al., Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors. Mol Endocrinol. 1995 Jan;9(1):72-85
  • Latest
    J:232442 Whitfield M, et al., Liver X Receptors (LXRs) Alpha and Beta Play Distinct Roles in the Mouse Epididymis. Biol Reprod. 2016 Mar;94(3):55

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory