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Nr1h2
Gene Detail
Symbol

Name
ID
Nr1h2
nuclear receptor subfamily 1, group H, member 2
MGI:1352463
Synonyms
LXRB, LXRbeta, RIP15, Unr2
Feature Type
protein coding gene
Genetic Map
Chromosome 7
28.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:44549616-44553951 bp, - strand
From VEGA annotation of GRCm38

  4336 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21397  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: NR1H2
Gene Tree: Nr1h2

Human
homologs
NR1H2, nuclear receptor subfamily 1, group H, member 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7376
neXtProt AC: NX_P55055

Human Synonyms: LXR-b, LXRB, NER, NER-I, RIP15, UNR

Human Chr (Location): 19q13.3; chr19:50376423-50383028 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(3) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutations cause altered lipid, cholesterol and glucose metabolism and may lead to elevated cartilage matrix catabolism and PGE2 production, lipid-laden uterus myocytes and Sertoli cells, impaired uterus contractility and parturition, and higher susceptibility to bacterial infection.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Nr1h2 interacts with 43 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (58 annotations)
Process cellular lipid metabolic process, cholesterol homeostasis, ...
Component cytoplasm, nucleus
Function apolipoprotein A-I receptor binding, ATPase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (74)    Tissues (62)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 66
RT-PCR 8
cDNA source data(135)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nr1h2    NEW 
Molecular
reagents
All nucleic(137) cDNA(136) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000023074 (Evidence)
Ensembl Gene Model ENSMUSG00000060601 (Evidence)
Entrez Gene 22260 (Evidence)
UniGene 968
DFCI TC1574842, TC1584962
DoTS DT.493838
NIA Mouse Gene Index U134659
Consensus CDS Project CCDS21211.1, CCDS71947.1
International Mouse Phenotyping Consortium Status Nr1h2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023074 VEGA Gene Model | MGI Sequence Detail 4336 C57BL/6J ±  kb
transcript OTTMUST00000055715 VEGA | MGI Sequence Detail 1839 Not Applicable 
polypeptide OTTMUSP00000026720 VEGA | MGI Sequence Detail 446 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(10) UniProt(2)
Polymorphisms
SNPs within 2kb(84 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023257 Liver X receptor
InterPro IPR001723 Nuclear hormone receptor
InterPro IPR000536 Nuclear hormone receptor, ligand-binding domain
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000011394 oxysterols receptor LXR-beta
References
(Earliest) J:23077 Seol W, et al., Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors. Mol Endocrinol. 1995 Jan;9(1):72-85
(Latest) J:221134 Bindesboll C, et al., Liver X receptor regulates hepatic nuclear O-GlcNAc signaling and carbohydrate responsive element-binding protein activity. J Lipid Res. 2015 Apr;56(4):771-85
All references(172)
Other
accession IDs
MGD-MRK-24047, MGI:103179, MGI:2141876

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory