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Nr1h2
Gene Detail
 Symbol
Name
ID
Nr1h2
nuclear receptor subfamily 1, group H, member 2
MGI:1352463
Synonyms LXRB, LXRbeta, RIP15, Unr2
Feature Type protein coding gene
Genetic Map
Chromosome 7
28.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:44549616-44553951 bp, - strand
From VEGA annotation of GRCm38

  4336 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21397  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Gene Tree: Nr1h2

Human
homologs
Human Homolog NR1H2, nuclear receptor subfamily 1, group H, member 2
NCBI Gene ID 7376
neXtProt AC  NX_P55055
Human Synonyms  LXR-b, LXRB, NER, NER-I, RIP15, UNR
Human Chr (Location)  19q13.3; chr19:50376423-50383028 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(3) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutations cause altered lipid, cholesterol and glucose metabolism and may lead to elevated cartilage matrix catabolism and PGE2 production, lipid-laden uterus myocytes and Sertoli cells, impaired uterus contractility and parturition, and higher susceptibility to bacterial infection.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Nr1h2 interacts with 43 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (57 annotations)
Process cellular lipid metabolic process, cholesterol homeostasis, ...
Component cytoplasm, nucleus
Function apolipoprotein A-I receptor binding, ATPase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (74)    Tissues (62)    Images (16)
Theiler Stages: 2, 3, 4, 5, 17, 18, 19, 21, 23, 27, 28
Assay TypeResults
RNA in situ 66
RT-PCR 8
cDNA source data(135)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(137) cDNA(136) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000023074 (Evidence)
Ensembl Gene ModelENSMUSG00000060601 (Evidence)
Entrez Gene22260 (Evidence)
UniGene968
DFCITC1574842, TC1584962
DoTSDT.493838
NIA Mouse Gene IndexU134659
Consensus CDS ProjectCCDS21211.1, CCDS71947.1
International Mouse Knockout Project StatusNr1h2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023074 VEGA Gene Model | MGI Sequence Detail 4336 C57BL/6J ±  kb
transcript OTTMUST00000055715 VEGA | MGI Sequence Detail 1839 Not Applicable 
polypeptide OTTMUSP00000026720 VEGA | MGI Sequence Detail 446 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(10) UniProt(2)
Polymorphisms SNPs within 2kb(84 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023257 Liver X receptor
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR001723 Steroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000011394 oxysterols receptor LXR-beta
References (Earliest) J:23077 Seol W, et al., Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors. Mol Endocrinol. 1995 Jan;9(1):72-85
(Latest) J:212418 Sallam T, et al., The macrophage LBP gene is an LXR target that promotes macrophage survival and atherosclerosis. J Lipid Res. 2014 Mar 26;55(6):1120-1130
All references(168)
Other
accession IDs
MGD-MRK-24047, MGI:103179, MGI:2141876

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory