Nr1h3 MGI Mouse Gene Detail - MGI:1352462 - nuclear receptor subfamily 1, group H, member 3

Nr1h3 Gene Detail

Symbol

Nr1h3
Name

nuclear receptor subfamily 1, group H, member 3
Synonyms

LXR alpha, Unr1

Feature Type

protein coding gene
IDs

MGI:1352462
NCBI Gene: 22259
Gene Overview

MyGene.info: NR1H3

Sequence Map

Chr2:91184061-91202834 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

18774 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 50.52 cM
Mapping Data

6 experiments

Human Ortholog

NR1H3, nuclear receptor subfamily 1 group H member 3

Vertebrate Orthologs

9

Human Ortholog

NR1H3, nuclear receptor subfamily 1 group H member 3
Orthology source: HomoloGene, HGNC
Synonyms

LXR-a, LXRA, RLD-1
Links

HGNC:7966

NCBI Gene ID: 10062

neXtProt AC: NX_Q13133

UniProt: Q13133
Chr Location

11p11.2; chr11:47248300-47269033 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 21165
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 macaque, rhesus
HCOP

human homology predictions: NR1H3
Gene Tree

Nr1h3

Diseases

1 with Nr1h3 mouse models

Human Disease

Mouse Models

ovarian hyperstimulation syndrome

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

36 phenotypes from 9 alleles in 8 genetic backgrounds
57 phenotypes from multigenic genotypes
3 images
139 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (other)

1
Gene trapped

5
Radiation induced

1
Targeted

13
Transgenic

1
Genomic Mutations

4 involving Nr1h3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available

Mice homozygous for a knock-out allele exhibit decreased male fertility, increased suseceptibility to bacterial infection, and diet-sensitive increase in liver size, steatosis, and cholesterol level.

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All GO Annotations

68
GO References

20

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

154
Tissues

151
cDNA Data

42
Literature Summary

14

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN nr1h3

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Nr1h3 interacts with 53 markers (Mir1a-1, Mir1a-2, Mir17, ...) View All

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All Sequences

52
RefSeq

10
UniProt

3
CCDS

CCDS16426.1
UniGene

22690

			Length	Strain/Species	Flank
genomic	OTTMUSG00000014415	VEGA Gene Model \| MGI Sequence Detail	18774	C57BL/6J	± kb
transcript	OTTMUST00000034173	VEGA \| MGI Sequence Detail	1955	Not Applicable
polypeptide	OTTMUSP00000021983	VEGA \| MGI Sequence Detail	445	Not Applicable

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SNPs within 2kb

128 from dbSNP Build 142

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UniProt

3 Sequences
PDB

2ACL, 3FAL, 3FC6
InterPro Domains

IPR023257 Liver X receptor

IPR001723 Nuclear hormone receptor

IPR000536 Nuclear hormone receptor, ligand-binding domain

IPR013088 Zinc finger, NHR/GATA-type

IPR001628 Zinc finger, nuclear hormone receptor-type

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All nucleic 46

Genomic 1

cDNA 42

Primer pair 3

Microarray probesets 3

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MGI:1306811, MGI:2139165

Summaries

All 223

Developmental Gene Expression 14

Diseases 1

Gene Ontology 20

Phenotypes 139
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:239111 Griffett K, et al., Promiscuous activity of the LXR antagonist GSK2033 in a mouse model of fatty liver disease. Biochem Biophys Res Commun. 2016 Oct 21;479(3):424-428

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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