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Nr1h3 Gene Detail
Summary
  • Symbol
    Nr1h3
  • Name
    nuclear receptor subfamily 1, group H, member 3
  • Synonyms
    LXR alpha, Unr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352462
    NCBI Gene: 22259
  • Gene Overview
    MyGene.info: NR1H3
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr2:91184061-91202834 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      18774 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 50.52 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    NR1H3, nuclear receptor subfamily 1 group H member 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NR1H3, nuclear receptor subfamily 1 group H member 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LXR-a, LXRA, RLD-1
  • Links
    NCBI Gene ID: 10062
    neXtProt AC: NX_Q13133
    UniProt: Q13133

  • Chr Location
    11p11.2; chr11:47248300-47269033 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Nr1h3 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 9 alleles in 8 genetic backgrounds
    58 phenotypes from multigenic genotypes
    3 images
    144 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased male fertility, increased suseceptibility to bacterial infection, and diet-sensitive increase in liver size, steatosis, and cholesterol level.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    70
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    154
  • Tissues
    151
  • cDNA Data
    43
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000014415 VEGA Gene Model | MGI Sequence Detail 18774 C57BL/6J ±  kb
    transcript OTTMUST00000034173 VEGA | MGI Sequence Detail 1955 Not Applicable  
    polypeptide OTTMUSP00000021983 VEGA | MGI Sequence Detail 445 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      128 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      Genomic 1
      cDNA 43
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1306811, MGI:2139165
    References
    more
    • Summaries
      All 275
      Developmental Gene Expression 14
      Diseases 1
      Gene Ontology 21
      Phenotypes 144
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:254237 Dang EV, et al., Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation. Cell. 2017 Nov 16;171(5):1057-1071.e11
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    07/10/2018
    MGI 6.12     		The Jackson Laboratory