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Nr1h3 Gene Detail
Summary
  • Symbol
    Nr1h3
  • Name
    nuclear receptor subfamily 1, group H, member 3
  • Synonyms
    LXR alpha, Unr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352462
    NCBI Gene: 22259
  • Gene Overview
    MyGene.info: NR1H3
Location & Maps
more
  • Sequence Map
    Chr2:91184061-91202834 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      18774 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 50.52 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    NR1H3, nuclear receptor subfamily 1 group H member 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NR1H3, nuclear receptor subfamily 1 group H member 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LXR-a, LXRA, RLD-1
  • Links
    NCBI Gene ID: 10062
    neXtProt AC: NX_Q13133

  • Chr Location
    11p11.2; chr11:47248300-47269033 (+)  GRCh38.p2
Human Diseases
more
  • Diseases
    1 with Nr1h3 mouse models

Human Disease Mouse Models
       Ovarian Hyperstimulation Syndrome; OHSS   OMIM: 608115 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 8 alleles in 7 genetic backgrounds
    55 phenotypes from multigenic genotypes
    2 images
    135 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    21
  • Chemically induced (other)
    1
  • Gene trapped
    5
  • Radiation induced
    1
  • Targeted
    13
  • Transgenic
    1
  • Genomic Mutations
    4 involving Nr1h3
  • Incidental Mutations
    Mutagenetix , APF
Mice homozygous for a knock-out allele exhibit decreased male fertility, increased suseceptibility to bacterial infection, and diet-sensitive increase in liver size, steatosis, and cholesterol level.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    68
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    154
  • Tissues
    151
  • cDNA Data
    42
  • Literature Summary
    14
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014415 VEGA Gene Model | MGI Sequence Detail 18774 C57BL/6J ±  kb
transcript OTTMUST00000034167 VEGA | MGI Sequence Detail 1802 Not Applicable  
polypeptide OTTMUSP00000015311 VEGA | MGI Sequence Detail 445 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    128 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 46
    Genomic 1
    cDNA 42
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGI:1306811, MGI:2139165
References
more
  • Summaries
    All 211
    Developmental Gene Expression 14
    Diseases 1
    Gene Ontology 20
    Phenotypes 135
  • Earliest
    J:210948 Lehmann JM, et al., Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J Biol Chem. 1997 Feb 7;272(6):3137-40
  • Latest
    J:234473 Marmugi A, et al., Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way. Toxicol Appl Pharmacol. 2016 Jul 15;303:90-100
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory