About   Help   FAQ
Nr1h3 Gene Detail
Summary
  • Symbol
    Nr1h3
  • Name
    nuclear receptor subfamily 1, group H, member 3
  • Synonyms
    LXR alpha, Unr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352462
    NCBI Gene: 22259
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:91014406-91033179 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 50.52 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    629 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352462
 protein coding gene Chr2:91014406-91033189 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026144
 protein coding gene Chr2:92490697-92511930 (-)
A/J MGP_AJ_G0026105
 protein coding gene Chr2:88794688-88813745 (-)
AKR/J MGP_AKRJ_G0026086
 protein coding gene Chr2:91248802-91268755 (-)
BALB/cJ MGP_BALBcJ_G0026114
 protein coding gene Chr2:88974353-88993474 (-)
C3H/HeJ MGP_C3HHeJ_G0025865
 protein coding gene Chr2:91526442-91545858 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026565
 protein coding gene Chr2:95757176-95778649 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023955
 protein coding gene Chr2:85305831-85323582 (-)
CAST/EiJ MGP_CASTEiJ_G0025330
 protein coding gene Chr2:92055153-92073223 (-)
CBA/J MGP_CBAJ_G0025843
 protein coding gene Chr2:99004782-99025257 (-)
DBA/2J MGP_DBA2J_G0025979
 protein coding gene Chr2:88395221-88414400 (-)
FVB/NJ MGP_FVBNJ_G0025942
 protein coding gene Chr2:87500352-87523155 (-)
LP/J MGP_LPJ_G0026083
 protein coding gene Chr2:92704320-92725117 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025968
 protein coding gene Chr2:102044476-102065399 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026619
 protein coding gene Chr2:91315059-91337533 (-)
PWK/PhJ MGP_PWKPhJ_G0025065
 protein coding gene Chr2:88124245-88142757 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024866
 protein coding gene Chr2:90887464-90908724 (-)
WSB/EiJ MGP_WSBEiJ_G0025397
 protein coding gene Chr2:91909984-91933544 (-)



Homology
more
  • Human Ortholog
    NR1H3, nuclear receptor subfamily 1 group H member 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NR1H3, nuclear receptor subfamily 1 group H member 3
  • Synonyms
    LXR-a, LXRA, RLD-1
  • Links
    NCBI Gene ID: 10062
    UniProt: Q13133

  • Chr Location
    11p11.2; chr11:47248300-47269033 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Nr1h3 mouse models; 4 with human NR1H3 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 9 alleles in 8 genetic backgrounds
    67 phenotypes from multigenic genotypes
    3 images
    216 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased male fertility, increased suseceptibility to bacterial infection, and diet-sensitive increase in liver size, steatosis, and cholesterol level.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    143
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    935
  • Tissues
    182
  • cDNA Data
    43
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002108 Ensembl Gene Model | MGI Sequence Detail 18774 C57BL/6J ±  kb
    transcript ENSMUST00000002177 Ensembl | MGI Sequence Detail 1802 Not Applicable  
    polypeptide ENSMUSP00000002177 Ensembl | MGI Sequence Detail 445 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 1
      cDNA 43
      Primer pair 6

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1306811, MGI:2139165
    References
    more
    • Summaries
      All 375
      Developmental Gene Expression 18
      Diseases 2
      Gene Ontology 31
      Phenotypes 216
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:368271 Ban SY, et al., Liver-X receptor beta-selective agonist CE9A215 regulates Alzheimer's disease-associated pathology in a 3xTg-AD mouse model. Biomed Pharmacother. 2025 Mar;184:117895
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory