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Nr1h3
Gene Detail
Symbol

Name
ID
Nr1h3
nuclear receptor subfamily 1, group H, member 3
MGI:1352462
Synonyms
LXR alpha, Unr1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
50.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr2:91184061-91202834 bp, - strand
From VEGA annotation of GRCm38

  18774 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21165  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: NR1H3
Gene Tree: Nr1h3

Human
homologs
NR1H3, nuclear receptor subfamily 1, group H, member 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10062
neXtProt AC: NX_Q13133

Human Synonyms: LXR-a, LXRA, RLD-1

Human Chr (Location): 11p11.2; chr11:47248300-47269033 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(5) Targeted(12)
Genomic Mutations involving Nr1h3 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit decreased male fertility, increased suseceptibility to bacterial infection, and diet-sensitive increase in liver size, steatosis, and cholesterol level.
 
Human Diseases Modeled in Mice Using Nr1h3 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Nr1h3 interacts with 53 markers (Mir1a-1, Mir1a-2, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (69 annotations)
Process apoptotic cell clearance, cellular lipid metabolic process, ...
Component cytoplasm, nuclear chromatin, ...
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (154)    Tissues (151)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 145
RT-PCR 9
cDNA source data(42)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN nr1h3    NEW 
Molecular
reagents
All nucleic(46) Genomic(1) cDNA(42) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000014415 (Evidence)
Ensembl Gene Model ENSMUSG00000002108 (Evidence)
Entrez Gene 22259 (Evidence)
UniGene 22690
DFCI TC1588420, TC1588494, TC1598464
DoTS DT.101354358, DT.532801, DT.94296113, DT.94296114
NIA Mouse Gene Index U023018
PDB 2ACL, 3FAL, 3FC6
Consensus CDS Project CCDS16426.1
International Mouse Phenotyping Consortium Status Nr1h3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014415 VEGA Gene Model | MGI Sequence Detail 18774 C57BL/6J ±  kb
transcript OTTMUST00000034168 VEGA | MGI Sequence Detail 1738 Not Applicable 
polypeptide OTTMUSP00000015312 VEGA | MGI Sequence Detail 445 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(10) UniProt(3)
Polymorphisms
SNPs within 2kb(136 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023257 Liver X receptor
InterPro IPR001723 Nuclear hormone receptor
InterPro IPR000536 Nuclear hormone receptor, ligand-binding domain
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000011395 oxysterols receptor LXR-alpha
References
(Earliest) J:210948 Lehmann JM, et al., Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J Biol Chem. 1997 Feb 7;272(6):3137-40
(Latest) J:221134 Bindesboll C, et al., Liver X receptor regulates hepatic nuclear O-GlcNAc signaling and carbohydrate responsive element-binding protein activity. J Lipid Res. 2015 Apr;56(4):771-85
All references(198)
Disease annotation references (1)
Other
accession IDs
MGI:1306811, MGI:2139165

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory