Nr1h3
Gene Detail

Symbol Name ID

Nr1h3 nuclear receptor subfamily 1, group H, member 3 MGI:1352462

Synonyms

LXR alpha, Unr1

Feature Type

protein coding gene

Genetic Map

Chromosome 2

50.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr2:91184061-91202834 bp, - strand From VEGA annotation of GRCm38   18774 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21165  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Nr1h3

Human homologs

Human Homolog		NR1H3, nuclear receptor subfamily 1, group H, member 3
NCBI Gene ID		10062
neXtProt AC		NX_Q13133
Human Synonyms		LXR-a, LXRA, RLD-1
Human Chr (Location)		11p11.2; chr11:47269851-47290584 (+)  GRCh37.p13

Alleles and phenotypes

All alleles(15) : Targeted(10) Gene trapped(5)
 

Mice homozygous for a knock-out allele exhibit decreased male fertility, increased suseceptibility to bacterial infection, and diet-sensitive increase in liver size, steatosis, and cholesterol level.

 
Human Diseases Modeled Using Mouse Nr1h3 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (61 annotations)

Process	apoptotic cell clearance, cellular lipid metabolic process, ...
Component	cytoplasm, nuclear chromatin, ...
Function	DNA binding, ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)

Data Summary: Results (161)    Tissues (155)    Images (8)
Theiler Stages: 2, 3, 4, 5, 17, 21, 22, 23, 28

Assay Type	Results
RNA in situ	145
RT-PCR	16

cDNA source data(42)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(46) Genomic(1) cDNA(42) Primer pair(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000014415 (Evidence)
Ensembl Gene Model	ENSMUSG00000002108 (Evidence)
Entrez Gene	22259 (Evidence)
UniGene	22690
DFCI	TC1588420, TC1588494, TC1598464
DoTS	DT.101354358, DT.532801, DT.94296113, DT.94296114
NIA Mouse Gene Index	U023018
PDB	2ACL, 3FAL, 3FC6
Consensus CDS Project	CCDS16426.1
International Mouse Knockout Project Status	Nr1h3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000014415	VEGA Gene Model | MGI Sequence Detail	18774	C57BL/6J
transcript	OTTMUST00000034173	VEGA | MGI Sequence Detail	1955	Not Applicable
polypeptide	OTTMUSP00000021983	VEGA | MGI Sequence Detail	445	Not Applicable

All sequences(60) RefSeq(10) UniProt(3)

Polymorphisms

SNPs within 2kb(136 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR023257	Liver X receptor
InterPro	IPR008946	Nuclear hormone receptor, ligand-binding
InterPro	IPR000536	Nuclear hormone receptor, ligand-binding, core
InterPro	IPR001723	Steroid hormone receptor
InterPro	IPR013088	Zinc finger, NHR/GATA-type
InterPro	IPR001628	Zinc finger, nuclear hormone receptor-type
Protein Ontology	PR:000011395	oxysterols receptor LXR-alpha

References

(Earliest) J:47971 Peet DJ, et al., Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell. 1998 May 29;93(5):693-704
(Latest) J:204840 Pascual-Garcia M, et al., Reciprocal negative cross-talk between liver X receptors (LXRs) and STAT1: effects on IFN-gamma-induced inflammatory responses and LXR-dependent gene expression. J Immunol. 2013 Jun 15;190(12):6520-32
All references(179)

Other accession IDs

MGI:1306811, MGI:2139165