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Nr1h3
Gene Detail
Symbol

Name
ID
Nr1h3
nuclear receptor subfamily 1, group H, member 3
MGI:1352462
Synonyms
LXR alpha, Unr1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
50.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr2:91184061-91202834 bp, - strand
From VEGA annotation of GRCm38

  18774 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21165  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Nr1h3

Human
homologs
Human Homolog NR1H3, nuclear receptor subfamily 1, group H, member 3
NCBI Gene ID 10062
neXtProt AC  NX_Q13133
Human Synonyms  LXR-a, LXRA, RLD-1
Human Chr (Location)  11p11.2; chr11:47248300-47269033 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(5) Targeted(12)
Genomic Mutations involving Nr1h3 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit decreased male fertility, increased suseceptibility to bacterial infection, and diet-sensitive increase in liver size, steatosis, and cholesterol level.
 
Human Diseases Modeled Using Mouse Nr1h3 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Interactions
Nr1h3 interacts with 53 markers (Mir1a-1, Mir1a-2, Mir17, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (13 records)
Data Summary: Results (154)    Tissues (151)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 145
RT-PCR 9
cDNA source data(42)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(46) Genomic(1) cDNA(42) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000014415 (Evidence)
Ensembl Gene ModelENSMUSG00000002108 (Evidence)
Entrez Gene22259 (Evidence)
UniGene22690
DFCITC1598464, TC1588494, TC1588420
DoTSDT.94296113, DT.94296114, DT.532801, DT.101354358
NIA Mouse Gene IndexU023018
PDB2ACL, 3FAL, 3FC6
Consensus CDS ProjectCCDS16426.1
International Mouse Knockout Project StatusNr1h3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014415 VEGA Gene Model | MGI Sequence Detail 18774 C57BL/6J ±  kb
transcript OTTMUST00000034173 VEGA | MGI Sequence Detail 1955 Not Applicable 
polypeptide OTTMUSP00000021983 VEGA | MGI Sequence Detail 445 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(10) UniProt(5)
Polymorphisms
SNPs within 2kb(136 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023257 Liver X receptor
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR001723 Steroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000011395 oxysterols receptor LXR-alpha
References
(Earliest) J:210948 Lehmann JM, et al., Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J Biol Chem. 1997 Feb 7;272(6):3137-40
(Latest) J:212761 Astapova I, et al., Hepatic nuclear corepressor 1 regulates cholesterol absorption through a TRbeta1-governed pathway. J Clin Invest. 2014 May 1;124(5):1976-86
All references(195)
Disease annotation references (1)
Other
accession IDs
MGI:1306811, MGI:2139165

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory