About   Help   FAQ
Nr1h3
Gene Detail
 Symbol
Name
ID
Nr1h3
nuclear receptor subfamily 1, group H, member 3
MGI:1352462
Synonyms LXR alpha, Unr1
Feature Type protein coding gene
Genetic Map
Chromosome 2
50.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr2:91184061-91202834 bp, - strand
From VEGA annotation of GRCm38

  18774 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21165  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Nr1h3

Human
homologs
Human Homolog NR1H3, nuclear receptor subfamily 1, group H, member 3
NCBI Gene ID 10062
neXtProt AC  NX_Q13133
Human Synonyms  LXR-a, LXRA, RLD-1
Human Chr (Location)  11p11.2; chr11:47248300-47269033 (+)  GRCh38
Alleles
and
phenotypes
All alleles(15) : Targeted(10) Gene trapped(5)
 
Mice homozygous for a knock-out allele exhibit decreased male fertility, increased suseceptibility to bacterial infection, and diet-sensitive increase in liver size, steatosis, and cholesterol level.
 
Human Diseases Modeled Using Mouse Nr1h3 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (62 annotations)
Process apoptotic cell clearance, cellular lipid metabolic process, ...
Component cytoplasm, nuclear chromatin, ...
Function DNA binding, ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (161)    Tissues (155)    Images (8)
Theiler Stages: 2, 3, 4, 5, 17, 21, 22, 23, 28
Assay TypeResults
RNA in situ 145
RT-PCR 16
cDNA source data(42)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(46) Genomic(1) cDNA(42) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000014415 (Evidence)
Ensembl Gene ModelENSMUSG00000002108 (Evidence)
Entrez Gene22259 (Evidence)
UniGene22690
DFCITC1588420, TC1588494, TC1598464
DoTSDT.101354358, DT.532801, DT.94296113, DT.94296114
NIA Mouse Gene IndexU023018
PDB2ACL, 3FAL, 3FC6
Consensus CDS ProjectCCDS16426.1
International Mouse Knockout Project StatusNr1h3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014415 VEGA Gene Model | MGI Sequence Detail 18774 C57BL/6J ±  kb
transcript OTTMUST00000034173 VEGA | MGI Sequence Detail 1955 Not Applicable 
polypeptide OTTMUSP00000021983 VEGA | MGI Sequence Detail 445 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(10) UniProt(3)
Polymorphisms SNPs within 2kb(136 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023257 Liver X receptor
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR001723 Steroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000011395 oxysterols receptor LXR-alpha
References (Earliest) J:47971 Peet DJ, et al., Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell. 1998 May 29;93(5):693-704
(Latest) J:206173 Rong X, et al., LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition. Cell Metab. 2013 Nov 5;18(5):685-97
All references(182)
Other
accession IDs
MGI:1306811, MGI:2139165

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/08/2014
MGI 5.17
The Jackson Laboratory