Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin DNA binding activity. Contributes to nuclear receptor activity and transcription cis-regulatory region binding activity. Involved in several processes, including cholesterol homeostasis; negative regulation of secretion; and regulation of transcription by RNA polymerase II. Acts upstream of or within cellular lipid metabolic process and negative regulation of DNA-templated transcription. Located in cytoplasm and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including 1st branchial arch; genitourinary system; gut; hemolymphoid system gland; and nervous system. Used to study ovarian hyperstimulation syndrome. Human ortholog(s) of this gene implicated in cerebral infarction; cerebrovascular disease; myocardial infarction; and obesity. Orthologous to human NR1H3 (nuclear receptor subfamily 1 group H member 3).
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