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Nr0b1
Gene Detail
Symbol

Name
ID
Nr0b1
nuclear receptor subfamily 0, group B, member 1
MGI:1352460
Synonyms
Ahc, Ahch, AHX, Dax1, DAX-1
Feature Type
protein coding gene
Genetic Map
Chromosome X
39.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
ChrX:86191764-86195947 bp, + strand
From VEGA annotation of GRCm38

  4184 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:403  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Nr0b1

Human
homologs
Human Homolog NR0B1, nuclear receptor subfamily 0, group B, member 1
NCBI Gene ID 190
neXtProt AC  NX_P51843
Human Synonyms  AHC, AHCH, AHX, DAX1, DAX-1, DSS, GTD, HHG, NROB1, SRXY2
Human Chr (Location)  Xp21.3; chrX:30304422-30309378 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human NR0B1
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from APF )
 
Mutations that inactivate this X-linked gene result in abnormal repoductive development in the hemizygote, ranging from defects in testes development and spermatogenesis to complete male to female sex reversal depending on genetic background.
 
Human Diseases Modeled Using Mouse Nr0b1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Nr0b1 interacts with 72 markers (Mir24-1, Mir24-2, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (60 annotations)
Process adrenal gland development, cell differentiation, ...
Component cytoplasm, membrane, ...
Function AF-2 domain binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (41 records)
Data Summary: Results (271)    Tissues (191)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 158
RT-PCR 107
cDNA source data(9)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) Genomic(6) cDNA(9) Primer pair(7) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000017945 (Evidence)
Ensembl Gene ModelENSMUSG00000025056 (Evidence)
Entrez Gene11614 (Evidence)
UniGene5180
DFCITC1585098
DoTSDT.50316329, DT.94154687, DT.55217260
PDB3F5C
Consensus CDS ProjectCCDS30260.1
International Mouse Knockout Project StatusNr0b1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017945 VEGA Gene Model | MGI Sequence Detail 4184 C57BL/6J ±  kb
transcript OTTMUST00000043377 VEGA | MGI Sequence Detail 1808 Not Applicable 
polypeptide OTTMUSP00000019489 VEGA | MGI Sequence Detail 472 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(3)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(57 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR025900 Nuclear receptor repeat
InterPro IPR001723 Steroid hormone receptor
Protein Ontology PR:000011390 nuclear receptor subfamily 0 group B member 1
References
(Earliest) J:32081 Swain A, et al., Mouse Dax1 expression is consistent with a role in sex determination as well as in adrenal and hypothalamus function. Nat Genet. 1996 Apr;12(4):404-9
(Latest) J:204621 Gagliardi A, et al., A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal. EMBO J. 2013 Aug 14;32(16):2231-47
All references(108)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-33777, MGD-MRK-37435, MGI:108393

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory