Nr0b1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nr0b1
nuclear receptor subfamily 0, group B, member 1
MGI:1352460

39 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nr0b1^{em2(IMPC)Wtsi}/Y C57BL/6N-Nr0b1^{em2(IMPC)Wtsi}/Wtsi	abnormal reproductive system morphology	J:211773
	increased bone mineral content	J:211773
	increased circulating alkaline phosphatase level	J:211773
	increased circulating iron level	J:211773
	increased circulating LDL cholesterol level	J:211773
	increased circulating magnesium level	J:211773
	increased circulating serum albumin level	J:211773
	increased hemoglobin content	J:211773
Nr0b1^tm1.1Lja/Y involves: 129S1/Sv * 129X1/SvJ	abnormal efferent ductules of testis morphology	J:71710
	abnormal fetal Leydig cell differentiation	J:81356
	abnormal Leydig cell morphology	J:71710
	abnormal lipid homeostasis	J:71710
	abnormal peritubular myoid cell morphology	J:71710
	abnormal seminiferous tubule epithelium morphology	J:51292, J:71710
	abnormal Sertoli cell development	J:81356
	abnormal spermatogenesis	J:51292
	abnormal testis cord formation	J:81356
	abnormal testis morphology	J:51292
	absent germ cells	J:51292
	decreased male germ cell number	J:51292
	decreased number of peritubular myoid cells	J:81356
	decreased testis weight	J:51292, J:71710
	dilated seminiferous tubule	J:71710
	disorganized testis cords	J:81356
	ectopic Leydig cells	J:71710, J:81356
	ectopic Sertoli cells	J:71710
	normal endocrine/exocrine gland phenotype	J:51292
	increased Leydig cell number	J:51292, J:71710
	increased Sertoli cell proliferation	J:71710
	increased testis tumor incidence	J:71710
	male infertility	J:51292, J:71710
	rete testis obstruction	J:71710
	retention of the adrenal gland x-zone	J:51292
	seminiferous tubule degeneration	J:51292, J:71710
	small testis	J:51292
Nr0b1^tm1.1Lja/Nr0b1^tm1.1Lja involves: 129S1/Sv * 129X1/SvJ	polyovular ovarian follicle	J:51292
Nr0b1^tm1Lja/Y C57BL/6JEi	abnormal primary sex determination	J:98922
Nr0b1^tm1Lja/Y C57BL/6JEi	primary sex reversal	J:98922
Nr0b1^tm1Lja/Y involves: C57BL/6JEi * DBA/2J	abnormal primary sex determination	J:98922
	ovotestis	J:98922
	primary sex reversal	J:98922

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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