Nr0b1^tm1.1Lja
Targeted Allele Detail

Summary

• Symbol: Nr0b1^tm1.1Lja
• Name: nuclear receptor subfamily 0, group B, member 1; targeted mutation 1.1, J Larry Jameson
• MGI ID: MGI:2159321
• Synonyms: Ahch^delta2, Dax1-, Dax1KO
• Gene: Nr0b1 Location: ChrX:85235381-85239553 bp, + strand Genetic Position: ChrX, 39.67 cM
• Alliance: Nr0b1^tm1.1Lja page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51292
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele is a derivative of Nr0b1^tm1Lja in which Cre-mediated recombination in vivo under control of a CMV promoter excised exon 2 in the germline. RT-PCR analyses of pituitary, adrenal glands, and gonads did not detect full length transcript in either homozygous female mice or hemizygous male mice. (J:51292)

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Nr0b1 Mutation: 8 strains or lines available

References

• Original: J:51292 Yu RN, et al., Role of Ahch in gonadal development and gametogenesis [see comments]. Nat Genet. 1998 Dec;20(4):353-7
• All: 19 reference(s)