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Nr4a2
Gene Detail
Symbol

Name
ID
Nr4a2
nuclear receptor subfamily 4, group A, member 2
MGI:1352456
Synonyms
HZF-3, Nurr1, RNR-1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
31.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:57106830-57124003 bp, - strand
From VEGA annotation of GRCm38

  17174 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4509  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NR4A2
Protein SuperFamily: nerve growth factor IB-like nuclear receptor
Gene Tree: Nr4a2

Human
homologs
NR4A2, nuclear receptor subfamily 4, group A, member 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4929
neXtProt AC: NX_P43354

Human Synonyms: HZF-3, NOT, NURR1, RNR1, TINUR

Human Chr (Location): 2q22-q23; chr2:156324432-156334683 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human NR4A2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene fail to develop dopaminergic neurons in the mesencephalon and die within the first 12 hours of life. Heterozygotes suffer from reduced motor performance in old age.
 
Human Diseases Modeled in Mice Using Nr4a2 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(3)
Interactions
Nr4a2 interacts with 337 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (66 annotations)
Process adult locomotory behavior, cellular response to extracellular stimulus, ...
Component cytoplasm, nucleoplasm, ...
Function DNA binding, glucocorticoid receptor binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (118 records)
Data Summary: Results (258)    Tissues (203)    Images (55)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 12
RNA in situ 220
Northern blot 17
RT-PCR 9
cDNA source data(11)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase nr4a2 ; ZFIN nr4a2a, nr4a2b    NEW 
Molecular
reagents
All nucleic(25) Genomic(8) cDNA(11) Primer pair(3) Other(3)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000012562 (Evidence)
Ensembl Gene Model ENSMUSG00000026826 (Evidence)
Entrez Gene 18227 (Evidence)
DFCI TC1654436, TC1750050, TC1577054, TC1598298, TC1646231, TC1623553
DoTS DT.40152523, DT.101314503, DT.40137822, DT.99843837, DT.101380467
NIA Mouse Gene Index U022644
Consensus CDS Project CCDS16043.1
International Mouse Phenotyping Consortium Status Nr4a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012562 VEGA Gene Model | MGI Sequence Detail 17174 C57BL/6J ±  kb
transcript OTTMUST00000029886 VEGA | MGI Sequence Detail 3568 Not Applicable 
polypeptide OTTMUSP00000013437 VEGA | MGI Sequence Detail 598 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(9) UniProt(4)
Polymorphisms
RFLP(2) : SNPs within 2kb(71 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR003070 Orphan nuclear receptor
InterPro IPR003073 Orphan nuclear receptor, NURR type
InterPro IPR001723 Steroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000011409 nuclear receptor subfamily 4 group A member 2
References
(Earliest) J:33283 Law SW, et al., Identification of a new brain-specific transcription factor, NURR1. Mol Endocrinol. 1992 Dec;6(12):2129-35
(Latest) J:220736 Bye CR, et al., Transcriptome analysis reveals transmembrane targets on transplantable midbrain dopamine progenitors. Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):E1946-55
All references(196)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-37459, MGI:108416

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory