Nr4a2
Gene Detail

Symbol Name ID

Nr4a2 nuclear receptor subfamily 4, group A, member 2 MGI:1352456

Synonyms

HZF-3, Nurr1, RNR-1

Feature Type

protein coding gene

Genetic Map

Chromosome 2

31.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr2:57106830-57124003 bp, - strand From VEGA annotation of GRCm38   17174 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4509  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: nerve growth factor IB-like nuclear receptor
Gene Tree: Nr4a2

Human homologs

Human Homolog		NR4A2, nuclear receptor subfamily 4, group A, member 2
NCBI Gene ID		4929
neXtProt AC		NX_P43354
Human Synonyms		HZF-3, NOT, NURR1, RNR1, TINUR
Human Chr (Location)		2q22-q23; chr2:157180944-157189287 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human NR4A2

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for disruptions in this gene fail to develop dopaminergic neurons in the mesencephalon and die within the first 12 hours of life. Heterozygotes suffer from reduced motor performance in old age.

 
Human Diseases Modeled Using Mouse Nr4a2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (53 annotations)

Process	adult locomotory behavior, cellular response to extracellular stimulus, ...
Component	cytoplasm, nucleus
Function	DNA binding, ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (98 records)
Data Summary: Results (258)    Tissues (193)    Images (55)
Theiler Stages: 14, 16, 17, 18, 19, 20, 21, 22, 23, 26, 28

Assay Type	Results
Immunohistochemistry	12
RNA in situ	220
Northern blot	17
RT-PCR	9

cDNA source data(11)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(25) Genomic(8) cDNA(11) Primer pair(3) Other(3)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000012562 (Evidence)
Ensembl Gene Model	ENSMUSG00000026826 (Evidence)
Entrez Gene	18227 (Evidence)
DFCI	TC1577054, TC1598298, TC1623553, TC1646231, TC1654436, TC1750050
DoTS	DT.101314503, DT.101380467, DT.40137822, DT.40152523, DT.99843837
NIA Mouse Gene Index	U022644
Consensus CDS Project	CCDS16043.1
International Mouse Knockout Project Status	Nr4a2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000012562	VEGA Gene Model | MGI Sequence Detail	17174	C57BL/6J
transcript	OTTMUST00000029884	VEGA | MGI Sequence Detail	3422	Not Applicable
polypeptide	OTTMUSP00000013435	VEGA | MGI Sequence Detail	598	Not Applicable

All sequences(54) RefSeq(4) UniProt(4)

Polymorphisms

RFLP(2) : SNPs(44 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008946	Nuclear hormone receptor, ligand-binding
InterPro	IPR000536	Nuclear hormone receptor, ligand-binding, core
InterPro	IPR003070	Orphan nuclear receptor
InterPro	IPR003073	Orphan nuclear receptor, NURR type
InterPro	IPR001723	Steroid hormone receptor
InterPro	IPR013088	Zinc finger, NHR/GATA-type
InterPro	IPR001628	Zinc finger, nuclear hormone receptor-type
Protein Ontology	PR:000011409	nuclear receptor subfamily 4 group A member 2

References

(Earliest) J:33283 Law SW, et al., Identification of a new brain-specific transcription factor, NURR1. Mol Endocrinol. 1992 Dec;6(12):2129-35
(Latest) J:194842 Yang J, et al., Dynamic temporal requirement of Wnt1 in midbrain dopamine neuron development. Development. 2013 Mar;140(6):1342-52
All references(168)

Other accession IDs

MGD-MRK-37459, MGI:108416