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Nr4a2
Gene Detail
Symbol

Name
ID
Nr4a2
nuclear receptor subfamily 4, group A, member 2
MGI:1352456
Synonyms
HZF-3, Nurr1, RNR-1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
31.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:57106830-57124003 bp, - strand
From VEGA annotation of GRCm38

  17174 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4509  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: nerve growth factor IB-like nuclear receptor
Gene Tree: Nr4a2

Human
homologs
Human Homolog   NR4A2, nuclear receptor subfamily 4, group A, member 2
NCBI Gene ID 4929
neXtProt AC  NX_P43354
Human Synonyms  HZF-3, NOT, NURR1, RNR1, TINUR
Human Chr (Location)  2q22-q23; chr2:156324432-156332775 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human NR4A2
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene fail to develop dopaminergic neurons in the mesencephalon and die within the first 12 hours of life. Heterozygotes suffer from reduced motor performance in old age.
 
Human Diseases Modeled in Mice Using Nr4a2 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(3)
Interactions
Nr4a2 interacts with 337 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (116 records)
Data Summary: Results (258)    Tissues (203)    Images (55)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 12
RNA in situ 220
Northern blot 17
RT-PCR 9
cDNA source data(11)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) Genomic(8) cDNA(11) Primer pair(3) Other(3)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000012562 (Evidence)
Ensembl Gene ModelENSMUSG00000026826 (Evidence)
Entrez Gene18227 (Evidence)
DFCITC1750050, TC1654436, TC1623553, TC1598298, TC1646231, TC1577054
DoTSDT.101314503, DT.101380467, DT.40137822, DT.99843837, DT.40152523
NIA Mouse Gene IndexU022644
Consensus CDS ProjectCCDS16043.1
International Mouse Knockout Project StatusNr4a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012562 VEGA Gene Model | MGI Sequence Detail 17174 C57BL/6J ±  kb
transcript OTTMUST00000029886 VEGA | MGI Sequence Detail 3568 Not Applicable 
polypeptide OTTMUSP00000013437 VEGA | MGI Sequence Detail 598 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(9) UniProt(4)
Polymorphisms
RFLP(2) : SNPs within 2kb(71 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR003070 Orphan nuclear receptor
InterPro IPR003073 Orphan nuclear receptor, NURR type
InterPro IPR001723 Steroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000011409 nuclear receptor subfamily 4 group A member 2
References
(Earliest) J:33283 Law SW, et al., Identification of a new brain-specific transcription factor, NURR1. Mol Endocrinol. 1992 Dec;6(12):2129-35
(Latest) J:217828 Moon M, et al., Correlation between orphan nuclear receptor Nurr1 expression and amyloid deposition in 5XFAD mice, an animal model of Alzheimer's disease. J Neurochem. 2015 Jan;132(2):254-62
All references(194)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-37459, MGI:108416

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory