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Gene Detail
nuclear receptor subfamily 4, group A, member 2
Synonyms HZF-3, Nurr1, RNR-1
Feature Type protein coding gene
Genetic Map
Chromosome 2
31.66 cM
Detailed Genetic Map ± 1 cM

Mapping data(4)
Sequence Map
Chr2:57106830-57124003 bp, - strand
From VEGA annotation of GRCm38

  17174 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:4509  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: nerve growth factor IB-like nuclear receptor
Gene Tree: Nr4a2

Human Homolog NR4A2, nuclear receptor subfamily 4, group A, member 2
NCBI Gene ID 4929
neXtProt AC  NX_P43354
Human Synonyms  HZF-3, NOT, NURR1, RNR1, TINUR
Human Chr (Location)  2q22-q23; chr2:156324432-156332775 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human NR4A2
alleles, and
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
Mice homozygous for disruptions in this gene fail to develop dopaminergic neurons in the mesencephalon and die within the first 12 hours of life. Heterozygotes suffer from reduced motor performance in old age.
Human Diseases Modeled Using Mouse Nr4a2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Nr4a2 interacts with 338 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
All GO classifications: (60 annotations)
Process adult locomotory behavior, cellular response to extracellular stimulus, ...
Component cytoplasm, nucleus
Function DNA binding, ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Literature Summary: (108 records)
Data Summary: Results (258)    Tissues (203)    Images (55)
Theiler Stages: 14, 16, 17, 18, 19, 20, 21, 22, 23, 26, 27, 28
Assay TypeResults
Immunohistochemistry 12
RNA in situ 220
Northern blot 17
cDNA source data(11)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
All nucleic(25) Genomic(8) cDNA(11) Primer pair(3) Other(3)
Microarray probesets(7)
Other database
VEGA Gene ModelOTTMUSG00000012562 (Evidence)
Ensembl Gene ModelENSMUSG00000026826 (Evidence)
Entrez Gene18227 (Evidence)
DFCITC1577054, TC1598298, TC1623553, TC1646231, TC1654436, TC1750050
DoTSDT.101314503, DT.101380467, DT.40137822, DT.40152523, DT.99843837
NIA Mouse Gene IndexU022644
Consensus CDS ProjectCCDS16043.1
International Mouse Knockout Project StatusNr4a2
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012562 VEGA Gene Model | MGI Sequence Detail 17174 C57BL/6J ±  kb
transcript OTTMUST00000029884 VEGA | MGI Sequence Detail 3422 Not Applicable 
polypeptide OTTMUSP00000013435 VEGA | MGI Sequence Detail 598 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(5) UniProt(4)
Polymorphisms RFLP(2) : SNPs within 2kb(71 from dbSNP Build 137)
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR003070 Orphan nuclear receptor
InterPro IPR003073 Orphan nuclear receptor, NURR type
InterPro IPR001723 Steroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000011409 nuclear receptor subfamily 4 group A member 2
References (Earliest) J:33283 Law SW, et al., Identification of a new brain-specific transcription factor, NURR1. Mol Endocrinol. 1992 Dec;6(12):2129-35
(Latest) J:208435 Yi SH, et al., Foxa2 acts as a co-activator potentiating expression of the Nurr1-induced DA phenotype via epigenetic regulation. Development. 2014 Feb;141(4):761-72
All references(185)
Disease annotation references (1)
accession IDs
MGD-MRK-37459, MGI:108416

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory