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Nr4a2 Gene Detail
Summary
  • Symbol
    Nr4a2
  • Name
    nuclear receptor subfamily 4, group A, member 2
  • Synonyms
    HZF-3, Nurr1, RNR-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352456
    NCBI Gene: 18227
Location & Maps
more
  • Sequence Map
    Chr2:57106830-57124003 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17174 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NR4A2, nuclear receptor subfamily 4 group A member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NR4A2, nuclear receptor subfamily 4 group A member 2
    Orthology source: HomoloGene
  • Synonyms
    HZF-3, NOT, NURR1, RNR1, TINUR
  • Links
    NCBI Gene ID: 4929
    neXtProt AC: NX_P43354

  • Chr Location
    2q22-q23; chr2:156324432-156334683 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Nr4a2 mouse models; 1 with human NR4A2 associations

Human Disease Mouse Models
       Schizophrenia; SCZD   OMIM: 181500 View 1 model
       Parkinson Disease, Late-Onset; PD   OMIM: 168600
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    45 phenotypes from 4 alleles in 7 genetic backgrounds
    2 phenotypes from multigenic genotypes
    3 images
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Nr4a2
  • Incidental Mutations
Mice homozygous for disruptions in this gene fail to develop dopaminergic neurons in the mesencephalon and die within the first 12 hours of life. Heterozygotes suffer from reduced motor performance in old age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012562 VEGA Gene Model | MGI Sequence Detail 17174 C57BL/6J ±  kb
transcript OTTMUST00000029886 VEGA | MGI Sequence Detail 3568 Not Applicable  
polypeptide OTTMUSP00000013437 VEGA | MGI Sequence Detail 598 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    61 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000011409 nuclear receptor subfamily 4 group A member 2
  • InterPro Domains
    IPR001723 Nuclear hormone receptor
    IPR000536 Nuclear hormone receptor, ligand-binding domain
    IPR003070 Orphan nuclear receptor
    IPR003073 Orphan nuclear receptor, NURR type
    IPR013088 Zinc finger, NHR/GATA-type
    IPR001628 Zinc finger, nuclear hormone receptor-type
Molecular
Reagents
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  • All nucleic 25
    Genomic 8
    cDNA 11
    Primer pair 3
    Other 3

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-37459, MGI:108416
References
more
  • Summaries
    All 211
    Developmental Gene Expression 128
    Diseases 1
    Gene Ontology 39
    Phenotypes 47
  • Earliest
    J:33283 Law SW, et al., Identification of a new brain-specific transcription factor, NURR1. Mol Endocrinol. 1992 Dec;6(12):2129-35
  • Latest
    J:229533 Kouwenhoven WM, et al., Engrailed 1 shapes the dopaminergic and serotonergic landscape through proper isthmic organizer maintenance and function. Biol Open. 2016;5(3):279-88

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory