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Nr2f1 Gene Detail
Summary
  • Symbol
    Nr2f1
  • Name
    nuclear receptor subfamily 2, group F, member 1
  • Synonyms
    COUP-TF1, COUP-TFI, Erbal3, Tcfcoup1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352451
    NCBI Gene: 13865
  • Gene Overview
    MyGene.info: NR2F1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr13:78188973-78199757 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10785 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 41.38 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    NR2F1, nuclear receptor subfamily 2 group F member 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NR2F1, nuclear receptor subfamily 2 group F member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BBOAS, BBSOAS, COUPTF1, COUP-TFI, EAR3, EAR-3, ERBAL3, SVP44, TCFCOUP1, TFCOUP1
  • Links
    NCBI Gene ID: 7025
    neXtProt AC: NX_P10589
    UniProt: P10589

  • Chr Location
    5q15; chr5:93583337-93594613 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 4 alleles in 4 genetic backgrounds
    17 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a null allele die perinatally with axon guidance defects in all forebrain commissures. Homozygotes for another null allele show neonatal death, impaired cranial ganglion IX formation and axon guidance, increased cochlear HC and support cell number, and altered cortex regionalization.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000023087 VEGA Gene Model | MGI Sequence Detail 10785 C57BL/6J ±  kb
    transcript OTTMUST00000055749 VEGA | MGI Sequence Detail 3207 Not Applicable  
    polypeptide OTTMUSP00000026734 VEGA | MGI Sequence Detail 420 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      44 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • InterPro Domains
      IPR001723 Nuclear hormone receptor
      IPR000536 Nuclear hormone receptor, ligand-binding domain
      IPR035500 Nuclear hormone receptor-like domain superfamily
      IPR003068 Transcription factor COUP
      IPR013088 Zinc finger, NHR/GATA-type
      IPR001628 Zinc finger, nuclear hormone receptor-type
    Molecular
    Reagents
    less
    • All nucleic 72
      Genomic 14
      cDNA 44
      Primer pair 7
      Other 7

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-18611, MGD-MRK-33774, MGI:101801
    References
    more
    • Summaries
      All 152
      Developmental Gene Expression 99
      Gene Ontology 8
      Phenotypes 36
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:264553 Tarchini B, et al., A spontaneous mouse deletion in Mctp1 uncovers a long-range cis-regulatory region crucial for NR2F1 function during inner ear development. Dev Biol. 2018;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory