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Nr2f1
Gene Detail
 Symbol
Name
ID
Nr2f1
nuclear receptor subfamily 2, group F, member 1
MGI:1352451
Synonyms COUP-TF1, COUP-TFI, Erbal3, Tcfcoup1
Feature Type protein coding gene
Genetic Map
Chromosome 13
41.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:78188973-78199757 bp, - strand
From VEGA annotation of GRCm38

  10785 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21158  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: retinoic X receptor-like nuclear receptor
Gene Tree: Nr2f1

Human
homologs
Human Homolog NR2F1, nuclear receptor subfamily 2, group F, member 1
NCBI Gene ID 7025
neXtProt AC  NX_P10589
Human Synonyms  BBOAS, BBSOAS, COUP-TFI, EAR3, EAR-3, ERBAL3, NR2F2, SVP44, TCFCOUP1, TFCOUP1
Human Chr (Location)  5q14; chr5:93583337-93594082 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human NR2F1
Alleles
and
phenotypes
All alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from APF )
 
Mice homozygous for a targeted mutation die perinatally displaying abnormal morphogenesis of the glossopharyngeal ganglion and nerve, abnormal regionalization of the neocortex, as well as defective nerve projection and reduced arborization in a subset of neurons in the peripheral nervous system.
 
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cerebral cortex regionalization, forebrain development, ...
Component nucleus
Function DNA binding, ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (77 records)
Data Summary: Results (188)    Tissues (122)    Images (34)
Theiler Stages: 2, 3, 4, 5, 9, 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 10
RNA in situ 109
Western blot 1
RT-PCR 65
RNase protection 3
cDNA source data(38)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(66) Genomic(14) cDNA(40) Primer pair(7) Other(5)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000023087 (Evidence)
Ensembl Gene ModelENSMUSG00000069171 (Evidence)
Entrez Gene13865 (Evidence)
UniGene439653
DFCITC1580737
Consensus CDS ProjectCCDS26658.1
International Mouse Knockout Project StatusNr2f1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023087 VEGA Gene Model | MGI Sequence Detail 10785 C57BL/6J ±  kb
transcript OTTMUST00000055749 VEGA | MGI Sequence Detail 3207 Not Applicable 
polypeptide OTTMUSP00000026734 VEGA | MGI Sequence Detail 420 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(6) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(45 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR001723 Steroid hormone receptor
InterPro IPR003068 Transcription factor COUP
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000011404 COUP transcription factor 1
References (Earliest) J:16740 Jonk LJ, et al., Isolation and developmental expression of retinoic-acid-induced genes. Dev Biol. 1994 Feb;161(2):604-14
(Latest) J:200199 Harrison-Uy SJ, et al., CoupTFI interacts with retinoic acid signaling during cortical development. PLoS One. 2013;8(3):e58219
All references(120)
Other
accession IDs
MGD-MRK-18611, MGD-MRK-33774, MGI:101801

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory