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Nr2f1 Gene Detail
Summary
  • Symbol
    Nr2f1
  • Name
    nuclear receptor subfamily 2, group F, member 1
  • Synonyms
    COUP-TF1, COUP-TFI, Erbal3, Tcfcoup1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352451
    NCBI Gene: 13865
  • Gene Overview
    MyGene.info: NR2F1
Location & Maps
more
  • Sequence Map
    Chr13:78188973-78199757 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10785 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NR2F1, nuclear receptor subfamily 2 group F member 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NR2F1, nuclear receptor subfamily 2 group F member 1
    Orthology source: HomoloGene
  • Synonyms
    BBOAS, BBSOAS, COUP-TFI, EAR3, EAR-3, ERBAL3, NR2F2, SVP44, TCFCOUP1, TFCOUP1
  • Links
    NCBI Gene ID: 7025
    neXtProt AC: NX_P10589

  • Chr Location
    5q14; chr5:93583337-93594611 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human NR2F1 associations

Human Disease Mouse Models
       Bosch-Boonstra-Schaaf Optic Atrophy Syndrome; BBSOAS   OMIM: 615722
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 4 alleles in 4 genetic backgrounds
    8 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    8
  • Transgenic
    1
  • Genomic Mutations
    1 involving Nr2f1
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023087 VEGA Gene Model | MGI Sequence Detail 10785 C57BL/6J ±  kb
transcript OTTMUST00000055749 VEGA | MGI Sequence Detail 3207 Not Applicable  
polypeptide OTTMUSP00000026734 VEGA | MGI Sequence Detail 420 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    44 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000011404 COUP transcription factor 1
  • InterPro Domains
    IPR001723 Nuclear hormone receptor
    IPR000536 Nuclear hormone receptor, ligand-binding domain
    IPR003068 Transcription factor COUP
    IPR013088 Zinc finger, NHR/GATA-type
    IPR001628 Zinc finger, nuclear hormone receptor-type
Molecular
Reagents
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  • All nucleic 69
    Genomic 14
    cDNA 42
    Primer pair 7
    Other 6

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-18611, MGD-MRK-33774, MGI:101801
References
more
  • Summaries
    All 128
    Developmental Gene Expression 85
    Gene Ontology 7
    Phenotypes 28
  • Earliest
    J:16740 Jonk LJ, et al., Isolation and developmental expression of retinoic-acid-induced genes. Dev Biol. 1994 Feb;161(2):604-14
  • Latest
    J:228726 Golonzhka O, et al., Pbx Regulates Patterning of the Cerebral Cortex in Progenitors and Postmitotic Neurons. Neuron. 2015 Dec 16;88(6):1192-207

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory