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Nr2f1
Gene Detail
Symbol

Name
ID
Nr2f1
nuclear receptor subfamily 2, group F, member 1
MGI:1352451
Synonyms
COUP-TF1, COUP-TFI, Erbal3, Tcfcoup1
Feature Type
protein coding gene
Genetic Map
Chromosome 13
41.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:78188973-78199757 bp, - strand
From VEGA annotation of GRCm38

  10785 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21158  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NR2F1
Protein SuperFamily: retinoic X receptor-like nuclear receptor
Gene Tree: Nr2f1

Human
homologs
NR2F1, nuclear receptor subfamily 2, group F, member 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7025
neXtProt AC: NX_P10589

Human Synonyms: BBOAS, BBSOAS, COUP-TFI, EAR3, EAR-3, ERBAL3, NR2F2, SVP44, TCFCOUP1, TFCOUP1

Human Chr (Location): 5q14; chr5:93583337-93594611 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human NR2F1

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(7)
Incidental mutations (data from APF )
Interactions
Nr2f1 interacts with 168 markers (Mir1b, Mir10a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process cerebral cortex regionalization, forebrain development, ...
Component nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (82 records)
Data Summary: Results (217)    Tissues (147)    Images (41)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 10
RNA in situ 145
Western blot 1
RT-PCR 58
RNase protection 3
cDNA source data(38)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nr2f1 ; ZFIN nr2f1a, nr2f1b    NEW 
Molecular
reagents
All nucleic(67) Genomic(14) cDNA(40) Primer pair(7) Other(6)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000023087 (Evidence)
Ensembl Gene Model ENSMUSG00000069171 (Evidence)
Entrez Gene 13865 (Evidence)
UniGene 439653
DFCI TC1580737
Consensus CDS Project CCDS26658.1
International Mouse Phenotyping Consortium Status Nr2f1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023087 VEGA Gene Model | MGI Sequence Detail 10785 C57BL/6J ±  kb
transcript OTTMUST00000055749 VEGA | MGI Sequence Detail 3207 Not Applicable 
polypeptide OTTMUSP00000026734 VEGA | MGI Sequence Detail 420 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(8) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(45 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001723 Nuclear hormone receptor
InterPro IPR000536 Nuclear hormone receptor, ligand-binding domain
InterPro IPR003068 Transcription factor COUP
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000011404 COUP transcription factor 1
References
(Earliest) J:16740 Jonk LJ, et al., Isolation and developmental expression of retinoic-acid-induced genes. Dev Biol. 1994 Feb;161(2):604-14
(Latest) J:222465 Borello U, et al., Sp8 and COUP-TF1 reciprocally regulate patterning and Fgf signaling in cortical progenitors. Cereb Cortex. 2014 Jun;24(6):1409-21
All references(126)
Other
accession IDs
MGD-MRK-18611, MGD-MRK-33774, MGI:101801

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory