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Abcc2
Gene Detail
 Symbol
Name
ID
Abcc2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
MGI:1352447
Synonyms Cmoat, Mrp2, multidrug resistance protein 2
Feature Type protein coding gene
Genetic Map
Chromosome 19
36.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr19:43782192-43840740 bp, + strand
From VEGA annotation of GRCm38

  58549 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68052  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Abcc2

Human
homologs
Human Homolog ABCC2, ATP-binding cassette, sub-family C (CFTR/MRP), member 2
NCBI Gene ID 1244
neXtProt AC  NX_Q92887
Human Synonyms  ABC30, CMOAT, cMRP, DJS, MRP2
Human Chr (Location)  10q24; chr10:99782694-99851905 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ABCC2
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene have moderately enlarged livers, elevated plasma and urine bilirubin, and a reduced ability to clear various drugs and carcinogens from the blood.
 
Interactions
Abcc2 interacts with 85 markers (Mir7-1, Mir22, Mir23a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process cellular chloride ion homeostasis, drug transmembrane transport, ...
Component apical plasma membrane, cell surface, ...
Function ATPase activity, ATPase activity, coupled to transmembrane movement of substances, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(28)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) cDNA(28) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000026258 (Evidence)
Ensembl Gene ModelENSMUSG00000025194 (Evidence)
Entrez Gene12780 (Evidence)
UniGene39054
DFCITC1683036, TC1727264
DoTSDT.40140293, DT.526252
NIA Mouse Gene IndexU019483
Consensus CDS ProjectCCDS29838.1
International Mouse Knockout Project StatusAbcc2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026258 VEGA Gene Model | MGI Sequence Detail 58549 C57BL/6J ±  kb
transcript OTTMUST00000064937 VEGA | MGI Sequence Detail 8027 Not Applicable 
polypeptide OTTMUSP00000032298 VEGA | MGI Sequence Detail 1543 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(4) UniProt(4)
Polymorphisms PCR(1) : SNPs within 2kb(739 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR003439 ABC transporter-like
InterPro IPR001140 ABC transporter, transmembrane domain
InterPro IPR011527 ABC transporter, transmembrane domain, type 1
InterPro IPR005292 Multi drug resistance-associated protein
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000003558 canalicular multispecific organic anion transporter 1
References (Earliest) J:42393 Lammert F, et al., The gene encoding the multispecific organic anion transporter of the hepatocyte canalicular membraine (Cmoat) maps to mouse Chromosome 19. Mamm Genome. 1998 Jan;9(1):87-88
(Latest) J:208127 Wen X, et al., Transgenic Expression of the Human MRP2 Transporter Reduces Cisplatin Accumulation and Nephrotoxicity in Mrp2-Null Mice. Am J Pathol. 2014 May;184(5):1299-308
All references(54)
Other
accession IDs
MGI:1196442, MGI:2147483

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory