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Skp2
Gene Detail
 Symbol
Name
ID
Skp2
S-phase kinase-associated protein 2 (p45)
MGI:1351663
Synonyms FBXL1
Feature Type protein coding gene
Genetic Map
Chromosome 15
3.84 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:9111985-9140451 bp, - strand
From NCBI annotation of GRCm38

  28467 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55942  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: conserved protein with F-box/LRR-repeat, Skp2 type
Gene Tree: Skp2

Human
homologs
Human Homolog SKP2, S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
NCBI Gene ID 6502
neXtProt AC  NX_Q13309
Human Synonyms  FBL1, FBXL1, FLB1, p45
Human Chr (Location)  5p13; chr5:36151989-36184041 (+)  GRCh38
Alleles
and
phenotypes
All alleles(31) : Gene trapped(27) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit reduced body weight, enlarged cell and nuclear sizes, polyploidy, reduced cell growth rate, overduplication of centrosomes, increased apoptosis rate, delayed wound healing, and aberrant immunoglobulin V(D)J recombination.
 
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process G1/S transition of mitotic cell cycle, G2/M transition of mitotic cell cycle, ...
Component aggresome, cytoplasm, ...
Function identical protein binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (15)    Tissues (11)    Images (5)
Theiler Stages: 4, 5, 20, 22, 24, 26, 28
Assay TypeResults
RNA in situ 15
cDNA source data(93)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(94) cDNA(94)
Microarray probesets(8)
Other database
links
Ensembl Gene ModelENSMUSG00000054115 (Evidence)
Entrez Gene27401 (Evidence)
UniGene35584
DFCITC1574092, TC1589550, TC1631809
DoTSDT.101220692, DT.101392256, DT.60117982, DT.94132619, DT.94215761
NIA Mouse Gene IndexU042092
Consensus CDS ProjectCCDS37037.1, CCDS37038.1
International Mouse Knockout Project StatusSkp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 27401 NCBI Gene Model | MGI Sequence Detail 28467 C57BL/6J ±  kb
transcript NM_013787 RefSeq | MGI Sequence Detail 3210 C57BL/6 
polypeptide Q9Z0Z3 UniProt | EBI | MGI Sequence Detail 424 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(5) UniProt(2)
Polymorphisms SNPs within 2kb(190 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001810 F-box domain, cyclin-like
Protein Ontology PR:000014909 S-phase kinase-associated protein 2
Graphical View of Protein Domain Structure
References (Earliest) J:54020 Hatakeyama S, et al., Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3859-63
(Latest) J:210319 Lu Z, et al., Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activity. Nat Commun. 2014;5:3463
All references(82)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory