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Skp2
Gene Detail
Symbol

Name
ID
Skp2
S-phase kinase-associated protein 2 (p45)
MGI:1351663
Synonyms
4930500A04Rik, FBXL1
Feature Type
protein coding gene
Genetic Map
Chromosome 15
3.84 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:9111985-9155425 bp, - strand
From VEGA annotation of GRCm38

  43441 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55942  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SKP2
Protein SuperFamily: conserved protein with F-box/LRR-repeat, Skp2 type
Gene Tree: Skp2

Human
homologs
SKP2, S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6502
neXtProt AC: NX_Q13309

Human Synonyms: FBL1, FBXL1, FLB1, p45

Human Chr (Location): 5p13; chr5:36151989-36192788 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(33) : Gene trapped(27) Targeted(5) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit reduced body weight, enlarged cell and nuclear sizes, polyploidy, reduced cell growth rate, overduplication of centrosomes, increased apoptosis rate, delayed wound healing, and aberrant immunoglobulin V(D)J recombination.
 
Interactions
Skp2 interacts with 398 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process G1/S transition of mitotic cell cycle, G2/M transition of mitotic cell cycle, ...
Component aggresome, cytoplasm, ...
Function identical protein binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (15)    Tissues (12)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 15
cDNA source data(94)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase skp2 ; ZFIN skp2    NEW 
Molecular
reagents
All nucleic(95) cDNA(95)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000045656 (Evidence)
Ensembl Gene Model ENSMUSG00000054115 (Evidence)
Entrez Gene 27401 (Evidence)
UniGene 35584
DFCI TC1631809, TC1727346, TC1574092, TC1589550
DoTS DT.60117982, DT.101392256, DT.101220692, DT.94132619, DT.94215761, DT.91409244
NIA Mouse Gene Index U042092
Consensus CDS Project CCDS37037.1, CCDS37038.1
International Mouse Phenotyping Consortium Status Skp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045656 VEGA Gene Model | MGI Sequence Detail 43441 C57BL/6J ±  kb
transcript OTTMUST00000119545 VEGA | MGI Sequence Detail 3118 Not Applicable 
polypeptide OTTMUSP00000066470 VEGA | MGI Sequence Detail 424 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(9) UniProt(3)
Polymorphisms
SNPs within 2kb(240 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001810 F-box domain, cyclin-like
InterPro IPR006553 Leucine-rich repeat, cysteine-containing subtype
Protein Ontology PR:000014909 S-phase kinase-associated protein 2
References
(Earliest) J:54020 Hatakeyama S, et al., Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3859-63
(Latest) J:219141 Wang J, et al., E3-ligase Skp2 regulates beta-catenin expression and maintains hematopoietic stem cell homing. Biochem Biophys Res Commun. 2014 Mar 14;445(3):566-71
All references(84)
Other
accession IDs
MGI:1922284

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory