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Skp2 Gene Detail
Summary
  • Symbol
    Skp2
  • Name
    S-phase kinase-associated protein 2 (p45)
  • Synonyms
    4930500A04Rik, FBXL1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351663
    NCBI Gene: 27401
  • Gene Overview
    MyGene.info: SKP2
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:9111985-9155425 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 3.84 cM, cytoband A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    237 from dbSNP Build 142
  • Strain Annotations
    9
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351663
protein coding gene Chr15:9111982-9155425 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0021671
protein coding gene Chr15:6029046-6073102 (-)
AKR/J MGP_AKRJ_G0021649
protein coding gene Chr15:6087223-6130926 (-)
BALB/cJ MGP_BALBcJ_G0021678
protein coding gene Chr15:5937728-5982395 (-)
C3H/HeJ MGP_C3HHeJ_G0021454
protein coding gene Chr15:6138434-6182746 (-)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0019654
protein coding gene Chr15:5594980-5638597 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0021423
protein coding gene Chr15:6550216-6602063 (-)
DBA/2J MGP_DBA2J_G0021547
protein coding gene Chr15:5909749-5953724 (-)
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0020551
protein coding gene Chr15:6022542-6072124 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    SKP2, S-phase kinase associated protein 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SKP2, S-phase kinase associated protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FBL1, FBXL1, FLB1, p45
  • Links
    NCBI Gene ID: 6502
    neXtProt AC: NX_Q13309
    UniProt: Q13309

  • Chr Location
    5p13.2; chr5:36151989-36192792 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced body weight, enlarged cell and nuclear sizes, polyploidy, reduced cell growth rate, overduplication of centrosomes, increased apoptosis rate, delayed wound healing, and aberrant immunoglobulin V(D)J recombination.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000054115 Ensembl Gene Model | MGI Sequence Detail 43441 C57BL/6J ±  kb
    transcript ENSMUST00000096482 Ensembl | MGI Sequence Detail 3118 Not Applicable  
    polypeptide ENSMUSP00000094225 Ensembl | MGI Sequence Detail 424 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 97
      cDNA 97

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1922284
    References
    more
    • Summaries
      All 112
      Developmental Gene Expression 10
      Gene Ontology 10
      Phenotypes 40
    • Earliest
      J:54020 Hatakeyama S, et al., Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3859-63
    • Latest
      J:254235 Lanctot AA, et al., Loss of Brap Results in Premature G1/S Phase Transition and Impeded Neural Progenitor Differentiation. Cell Rep. 2017 Aug 1;20(5):1148-1160

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory