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Skp2 Gene Detail
Summary
  • Symbol
    Skp2
  • Name
    S-phase kinase-associated protein 2 (p45)
  • Synonyms
    4930500A04Rik, FBXL1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351663
    NCBI Gene: 27401
  • Gene Overview
    MyGene.info: SKP2
Location & Maps
more
  • Sequence Map
    Chr15:9111985-9155425 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      43441 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 3.84 cM, cytoband A2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SKP2, S-phase kinase associated protein 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SKP2, S-phase kinase associated protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FBL1, FBXL1, FLB1, p45
  • Links
    NCBI Gene ID: 6502
    neXtProt AC: NX_Q13309

  • Chr Location
    5p13.2; chr5:36151989-36192788 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced body weight, enlarged cell and nuclear sizes, polyploidy, reduced cell growth rate, overduplication of centrosomes, increased apoptosis rate, delayed wound healing, and aberrant immunoglobulin V(D)J recombination.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045656 VEGA Gene Model | MGI Sequence Detail 43441 C57BL/6J ±  kb
transcript OTTMUST00000119545 VEGA | MGI Sequence Detail 3118 Not Applicable  
polypeptide OTTMUSP00000066470 VEGA | MGI Sequence Detail 424 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    237 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 95
    cDNA 95

    Microarray probesets 8
Other
Accession IDs
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MGI:1922284
References
more
  • Summaries
    All 83
    Developmental Gene Expression 8
    Gene Ontology 7
    Phenotypes 37
  • Earliest
    J:54020 Hatakeyama S, et al., Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3859-63
  • Latest
    J:233705 Zhao H, et al., Deletions of Retinoblastoma 1 (Rb1) and Its Repressing Target S Phase Kinase-associated protein 2 (Skp2) Are Synthetic Lethal in Mouse Embryogenesis. J Biol Chem. 2016 May 6;291(19):10201-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory