Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables ubiquitin-like ligase-substrate adaptor activity. Involved in positive regulation of double-strand break repair via homologous recombination and protein K63-linked ubiquitination. Acts upstream of or within several processes, including mitotic cell cycle phase transition; positive regulation of intracellular estrogen receptor signaling pathway; and positive regulation of protein polyubiquitination. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including blastocyst; brain; compacted morula; and retina nuclear layer. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human SKP2 (S-phase kinase associated protein 2).