About   Help   FAQ
Casr
Gene Detail
 Symbol
Name
ID
Casr
calcium-sensing receptor
MGI:1351351
Synonyms CaR, cation sensing receptor, Gprc2a
Feature Type protein coding gene
Genetic Map
Chromosome 16
25.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:36493696-36562141 bp, - strand
From VEGA annotation of GRCm38

  68446 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:332  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Casr

Human
homologs
Human Homolog CASR, calcium-sensing receptor
NCBI Gene ID 846
neXtProt AC  NX_P41180
Human Synonyms  CAR, EIG8, FHH, FIH, GPRC2A, HHC, HHC1, HYPOC1, NSHPT, PCAR1
Human Chr (Location)  3q13; chr3:122183683-122286503 (+)  GRCh38
Disease Associations  (5) Diseases Associated with Human CASR
Alleles
and
phenotypes
All alleles(11) : Chemically induced (ENU)(6) Chemically induced (other)(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit high levels of serum calcium and parathyroid hormone, parathyroid hyperplasia, bone defects, reduced growth, and early death. Carriers have elevated serum calcium, magnesium, and parathyroid hormone levels.
 
Human Diseases Modeled Using Mouse Casr (3)    Alleles Annotated to Human Diseases(7)    Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (43 annotations)
Process adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway, branching morphogenesis of an epithelial tube, ...
Component apical plasma membrane, axon, ...
Function calcium ion binding, drug binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (98)    Tissues (70)    Images (24)
Theiler Stages: 17, 18, 19, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 82
Western blot 3
RT-PCR 13
cDNA source data(5)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(13) Genomic(2) cDNA(5) Primer pair(5) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037977 (Evidence)
Ensembl Gene ModelENSMUSG00000051980 (Evidence)
Entrez Gene12374 (Evidence)
UniGene103619
DFCITC1587853
DoTSDT.87049703, DT.101358530
NIA Mouse Gene IndexU159133
Consensus CDS ProjectCCDS28154.1
International Mouse Knockout Project StatusCasr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037977 VEGA Gene Model | MGI Sequence Detail 68446 C57BL/6J ±  kb
transcript OTTMUST00000097874 VEGA | MGI Sequence Detail 4534 Not Applicable 
polypeptide OTTMUSP00000054890 VEGA | MGI Sequence Detail 1079 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(18) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(445 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR000337 GPCR, family 3
InterPro IPR017979 GPCR, family 3, conserved site
InterPro IPR017978 GPCR, family 3, C-terminal
InterPro IPR011500 GPCR, family 3, nine cysteines domain
Protein Ontology PR:000005058 extracellular calcium-sensing receptor
References (Earliest) J:43659 Pollak MR, et al., Mutations in the human Ca(2+)-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism [see comments]. Cell. 1993 Dec 31;75(7):1297-303
(Latest) J:202283 Mamillapalli R, et al., Mammary-specific ablation of the calcium-sensing receptor during lactation alters maternal calcium metabolism, milk calcium transport, and neonatal calcium accrual. Endocrinology. 2013 Sep;154(9):3031-42
All references(86)
Other
accession IDs
MGD-MRK-28074, MGI:104782

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory