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Grm8
Gene Detail
Symbol

Name
ID
Grm8
glutamate receptor, metabotropic 8
MGI:1351345
Synonyms
Gprc1h, mGluR8
Feature Type
protein coding gene
Genetic Map
Chromosome 6
11.97 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:27275121-28135178 bp, - strand
From VEGA annotation of GRCm38

  860058 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:654  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: metabotropic glutamate receptor-like protein
Gene Tree: Grm8

Human
homologs
Human Homolog GRM8, glutamate receptor, metabotropic 8
NCBI Gene ID 2918
neXtProt AC  NX_O00222
Human Synonyms  GLUR8, GPRC1H, mGlu8, MGLUR8
Human Chr (Location)  7q31.3-q32.1; chr7:126438598-127252381 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(2) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are overweight and mildly insulin resistant, and display increased anxiety-related responses and reduced exploration in a new environment. Mice homozygous for a different knock-out allele exhibit altered excitatory responses in the dentate gyrus.
 
Interactions
Grm8 interacts with 213 markers (Mir16-1, Mir16-2, Mir19a, ...)
Expression
Literature Summary: (7 records)
Data Summary: Results (111)    Tissues (84)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 65
RT-PCR 46
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(12) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000021285 (Evidence)
Ensembl Gene ModelENSMUSG00000024211 (Evidence)
Entrez Gene14823 (Evidence)
UniGene320732
DFCITC1674148, TC1591152
DoTSDT.60103134, DT.99839962, DT.99853461
NIA Mouse Gene IndexU027095
Consensus CDS ProjectCCDS39443.1
International Mouse Knockout Project StatusGrm8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021285 VEGA Gene Model | MGI Sequence Detail 860058 C57BL/6J ±  kb
transcript OTTMUST00000050461 VEGA | MGI Sequence Detail 3854 Not Applicable 
polypeptide OTTMUSP00000023554 VEGA | MGI Sequence Detail 908 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(14) UniProt(11)
Polymorphisms
SNPs within 2kb(4897 from dbSNP Build 137)    SNPs within 2kb including multiple locations(4899)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR000337 GPCR, family 3
InterPro IPR017979 GPCR, family 3, conserved site
InterPro IPR017978 GPCR, family 3, C-terminal
InterPro IPR000162 GPCR, family 3, metabotropic glutamate receptor
InterPro IPR001786 GPCR, family 3, metabotropic glutamate receptor 4
InterPro IPR000144 GPCR, family 3, metabotropic glutamate receptor 8
InterPro IPR011500 GPCR, family 3, nine cysteines domain
Protein Ontology PR:000008270 metabotropic glutamate receptor 8
References
(Earliest) J:24532 Duvoisin RM, et al., A novel metabotropic glutamate receptor expressed in the retina and olfactory bulb. J Neurosci. 1995 Apr;15(4):3075-83
(Latest) J:185665 Guo Z, et al., Tlx1/3 and ptf1a control the expression of distinct sets of transmitter and Peptide receptor genes in the developing dorsal spinal cord. J Neurosci. 2012 Jun 20;32(25):8509-20
All references(56)
Other
accession IDs
MGD-MRK-39599, MGI:109600

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory