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Grm8 Gene Detail
Summary
  • Symbol
    Grm8
  • Name
    glutamate receptor, metabotropic 8
  • Synonyms
    Gprc1h, mGluR8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351345
    NCBI Gene: 14823
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:27275119-28135178 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 11.97 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4876 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351345
protein coding gene Chr6:27275119-28135905 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030505
protein coding gene Chr6:24942767-25841818 (-)
A/J MGP_AJ_G0030478
protein coding gene Chr6:23872596-24752971 (-)
AKR/J MGP_AKRJ_G0030405
protein coding gene Chr6:24691250-25576715 (-)
BALB/cJ MGP_BALBcJ_G0030488
protein coding gene Chr6:24044043-24914043 (-)
C3H/HeJ MGP_C3HHeJ_G0030201
protein coding gene Chr6:24681601-25566677 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030942
protein coding gene Chr6:25695507-26627435 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028153
protein coding gene Chr6:22142957-22978447 (-)
CAST/EiJ MGP_CASTEiJ_G0029603
protein coding gene Chr6:24436823-25364806 (-)
CBA/J MGP_CBAJ_G0030179
protein coding gene Chr6:26623217-27588453 (-)
DBA/2J MGP_DBA2J_G0030323
protein coding gene Chr6:23844907-24712254 (-)
FVB/NJ MGP_FVBNJ_G0030277
protein coding gene Chr6:23612025-24467394 (-)
LP/J MGP_LPJ_G0030410
protein coding gene Chr6:25076917-25970930 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030313
protein coding gene Chr6:29076039-30142937 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030972
protein coding gene Chr6:24555489-25450389 (-)
PWK/PhJ MGP_PWKPhJ_G0029317
protein coding gene Chr6:23355057-24239383 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029153
protein coding gene Chr6:24237660-25145259 (-)
WSB/EiJ MGP_WSBEiJ_G0029679
protein coding gene Chr6:24519683-25417070 (-)



Homology
more
  • Human Ortholog
    GRM8, glutamate metabotropic receptor 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GRM8, glutamate metabotropic receptor 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GLUR8, GPRC1H, mGlu8, MGLUR8
  • Links
    NCBI Gene ID: 2918
    neXtProt AC: NX_O00222
    UniProt: O00222

  • Chr Location
    7q31.33; chr7:126438598-127253294 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are overweight and mildly insulin resistant, and display increased anxiety-related responses and reduced exploration in a new environment. Mice homozygous for a different knock-out allele exhibit altered excitatory responses in the dentate gyrus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024211 Ensembl Gene Model | MGI Sequence Detail 860060 C57BL/6J ±  kb
    transcript ENSMUST00000115323 Ensembl | MGI Sequence Detail 3856 Not Applicable  
    polypeptide ENSMUSP00000110978 Ensembl | MGI Sequence Detail 908 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 13
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-39599, MGI:109600
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 9
      Gene Ontology 8
      Phenotypes 16
    • Earliest
      J:24532 Duvoisin RM, et al., A novel metabotropic glutamate receptor expressed in the retina and olfactory bulb. J Neurosci. 1995 Apr;15(4):3075-83
    • Latest
      J:242531 Bedogni F, et al., Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms. Cereb Cortex. 2016 Jun;26(6):2517-2529

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory