About   Help   FAQ
Foxl2
Gene Detail
Symbol

Name
ID
Foxl2
forkhead box L2
MGI:1349428
Synonyms
Pfrk
Feature Type
protein coding gene
Genetic Map
Chromosome 9
51.41 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:98955607-98956847 bp, + strand
From VEGA annotation of GRCm38

  1241 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74992  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 zebrafish

Gene Tree: Foxl2

Human
homologs
Human Homolog FOXL2, forkhead box L2
NCBI Gene ID 668
neXtProt AC  NX_P58012
Human Synonyms  BPES, BPES1, PFRK, PINTO, POF3
Human Chr (Location)  3q23; chr3:138944224-138947140 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human FOXL2
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display increased postnatal lethality. Of animals surving to mating age, males are fully fertile and females are infertile.
 
Human Diseases Modeled Using Mouse Foxl2 (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Foxl2 interacts with 118 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (61 records)
Data Summary: Results (116)    Tissues (94)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 93
RT-PCR 23
cDNA source data(11)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(11) Primer pair(4)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000048289 (Evidence)
Ensembl Gene ModelENSMUSG00000050397 (Evidence)
Entrez Gene26927 (Evidence)
UniGene151239
NIA Mouse Gene IndexU010899
Consensus CDS ProjectCCDS23430.1
International Mouse Knockout Project StatusFoxl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048289 VEGA Gene Model | MGI Sequence Detail 1241 C57BL/6J ±  kb
transcript OTTMUST00000123908 VEGA | MGI Sequence Detail 1241 Not Applicable 
polypeptide OTTMUSP00000067538 VEGA | MGI Sequence Detail 375 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(12 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001766 Transcription factor, fork head
InterPro IPR018122 Transcription factor, fork head, conserved site
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007634 forkhead box protein L2
References
(Earliest) J:48144 Treier M, et al., Multistep signaling requirements for pituitary organogenesis in vivo. Genes Dev. 1998 Jun 1;12(11):1691-704
(Latest) J:214944 Fortin J, et al., Follicle-stimulating hormone synthesis and fertility depend on SMAD4 and FOXL2. FASEB J. 2014 Aug;28(8):3396-410
All references(109)
Disease annotation references (2)
Other
accession IDs
MGI:2143241

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory