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Foxl2
Gene Detail
Symbol

Name
ID
Foxl2
forkhead box L2
MGI:1349428
Synonyms
Pfrk
Feature Type
protein coding gene
Genetic Map
Chromosome 9
51.41 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:98955607-98956847 bp, + strand
From VEGA annotation of GRCm38

  1241 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74992  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 zebrafish

HCOP human homology predictions: FOXL2
Gene Tree: Foxl2

Human
homologs
FOXL2, forkhead box L2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 668
neXtProt AC: NX_P58012

Human Synonyms: BPES, BPES1, PFRK, PINTO, POF3

Human Chr (Location): 3q23; chr3:138944224-138947140 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human FOXL2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene display increased postnatal lethality. Of animals surving to mating age, males are fully fertile and females are infertile.
 
Human Diseases Modeled in Mice Using Foxl2 (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Foxl2 interacts with 118 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (72 records)
Data Summary: Results (200)    Tissues (127)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 28
RNA in situ 111
RT-PCR 61
cDNA source data(11)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: GEISHA FOXL2 ; Xenbase foxl2    NEW 
Molecular
reagents
All nucleic(18) cDNA(12) Primer pair(6)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000048289 (Evidence)
Ensembl Gene Model ENSMUSG00000050397 (Evidence)
Entrez Gene 26927 (Evidence)
UniGene 151239
NIA Mouse Gene Index U010899
Consensus CDS Project CCDS23430.1
International Mouse Phenotyping Consortium Status Foxl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048289 VEGA Gene Model | MGI Sequence Detail 1241 C57BL/6J ±  kb
transcript OTTMUST00000123908 VEGA | MGI Sequence Detail 1241 Not Applicable 
polypeptide OTTMUSP00000067538 VEGA | MGI Sequence Detail 375 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(12 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001766 Transcription factor, fork head
InterPro IPR018122 Transcription factor, fork head, conserved site
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007634 forkhead box protein L2
References
(Earliest) J:48144 Treier M, et al., Multistep signaling requirements for pituitary organogenesis in vivo. Genes Dev. 1998 Jun 1;12(11):1691-704
(Latest) J:221983 Heude E, et al., Etiology of craniofacial malformations in mouse models of blepharophimosis, ptosis and epicanthus inversus syndrome. Hum Mol Genet. 2015 Mar 15;24(6):1670-81
All references(119)
Disease annotation references (2)
Other
accession IDs
MGI:2143241

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory