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Foxl2 Gene Detail
Summary
  • Symbol
    Foxl2
  • Name
    forkhead box L2
  • Synonyms
    Pfrk
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349428
    NCBI Gene: 26927
  • Gene Overview
    MyGene.info: FOXL2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:98955607-98956847 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1241 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 51.41 cM, cytoband E4
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    FOXL2, forkhead box L2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    FOXL2, forkhead box L2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BPES, BPES1, PFRK, PINTO, POF3
  • Links
    NCBI Gene ID: 668
    neXtProt AC: NX_P58012
    UniProt: P58012

  • Chr Location
    3q22.3; chr3:138944224-138947140 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Foxl2 mouse models; 2 with human FOXL2 associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 6 alleles in 7 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display increased postnatal lethality. Of animals surving to mating age, males are fully fertile and females are infertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000048289 VEGA Gene Model | MGI Sequence Detail 1241 C57BL/6J ±  kb
    transcript OTTMUST00000123908 VEGA | MGI Sequence Detail 1241 Not Applicable  
    polypeptide OTTMUSP00000067538 VEGA | MGI Sequence Detail 375 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      12 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 13
      Primer pair 10
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2143241
    References
    more
    • Summaries
      All 152
      Developmental Gene Expression 97
      Diseases 2
      Gene Ontology 15
      Phenotypes 28
    • Earliest
      J:48144 Treier M, et al., Multistep signaling requirements for pituitary organogenesis in vivo. Genes Dev. 1998 Jun 1;12(11):1691-704
    • Latest
      J:257563 Huang K, et al., JAK signaling regulates germline cyst breakdown and primordial follicle formation in mice. Biol Open. 2018 Jan 17;7(1)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory