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Foxl2 Gene Detail
Summary
  • Symbol
    Foxl2
  • Name
    forkhead box L2
  • Synonyms
    Pfrk
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349428
    NCBI Gene: 26927
  • Gene Overview
    MyGene.info: FOXL2
Location & Maps
more
  • Sequence Map
    Chr9:98955607-98956847 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1241 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 51.41 cM, cytoband E4
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    FOXL2, forkhead box L2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    FOXL2, forkhead box L2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BPES, BPES1, PFRK, PINTO, POF3
  • Links
    NCBI Gene ID: 668
    neXtProt AC: NX_P58012

  • Chr Location
    3q22.3; chr3:138944224-138947140 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Foxl2 mouse models; 2 with human FOXL2 associations

Human Disease Mouse Models
       Blepharophimosis, Ptosis, and Epicanthus Inversus; BPES   OMIM: 110100 View 2 models
       Premature Ovarian Failure 3; POF3   OMIM: 608996
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 6 alleles in 7 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Targeted
    9
  • Genomic Mutations
    1 involving Foxl2
  • Incidental Mutations
Mice homozygous for disruptions in this gene display increased postnatal lethality. Of animals surving to mating age, males are fully fertile and females are infertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048289 VEGA Gene Model | MGI Sequence Detail 1241 C57BL/6J ±  kb
transcript OTTMUST00000123908 VEGA | MGI Sequence Detail 1241 Not Applicable  
polypeptide OTTMUSP00000067538 VEGA | MGI Sequence Detail 375 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    12 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    cDNA 12
    Primer pair 8
    Other 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:2143241
References
more
  • Summaries
    All 134
    Developmental Gene Expression 86
    Diseases 2
    Gene Ontology 15
    Phenotypes 26
  • Earliest
    J:48144 Treier M, et al., Multistep signaling requirements for pituitary organogenesis in vivo. Genes Dev. 1998 Jun 1;12(11):1691-704
  • Latest
    J:231673 Gustin SE, et al., WNT/beta-catenin and p27/FOXL2 differentially regulate supporting cell proliferation in the developing ovary. Dev Biol. 2016 Apr 15;412(2):250-60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory