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Foxl2 Gene Detail
Summary
  • Symbol
    Foxl2
  • Name
    forkhead box L2
  • Synonyms
    Pfrk
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349428
    NCBI Gene: 26927
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:98837495-98840601 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 51.41 cM, cytoband E4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    145 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349428
 protein coding gene Chr9:98837341-98840601 (+)
129S1/SvImJ ENSMUSG00200016292
 protein coding gene Chr9:95957749-95961004 (+)
A/J ENSMUSG00195014763
 protein coding gene Chr9:95199595-95202850 (+)
AKR/J ENSMUSG00220037186
 protein coding gene Chr9:95569135-95572390 (+)
BALB/cJ ENSMUSG00180022054
 protein coding gene Chr9:95519163-95522418 (+)
C3H/HeJ ENSMUSG00175011288
 protein coding gene Chr9:95862035-95865290 (+)
C57BL/6NJ ENSMUSG00215013452
 protein coding gene Chr9:95855289-95858545 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032555
 protein coding gene Chr9:94508330-94509566 (+)
CAST/EiJ ENSTCUG00005012554
 protein coding gene Chr9:95685865-95689123 (+)
CBA/J ENSMUSG00210014792
 protein coding gene Chr9:95700324-95703579 (+)
DBA/2J ENSMUSG00185010204
 protein coding gene Chr9:95878752-95882007 (+)
FVB/NJ ENSMUSG00205024465
 protein coding gene Chr9:95892834-95896089 (+)
JF1/MsJ ENSUMUG00000018015
 protein coding gene Chr9:95663168-95666429 (+)
LP/J ENSMUSG00230016682
 protein coding gene Chr9:96046750-96050005 (+)
NOD/ShiLtJ ENSMUSG00190030655
 protein coding gene Chr9:95521878-95525133 (+)
NZO/HlLtJ ENSMUSG00225019863
 protein coding gene Chr9:96222410-96225672 (+)
PWK/PhJ ENSLUMG00010024776
 protein coding gene Chr9:95643223-95646482 (+)
SPRET/EiJ ENSMSPG00010003841
 protein coding gene Chr9:97445986-97447761 (+)
WSB/EiJ ENSIUOG00005023220
 protein coding gene Chr9:94953573-94956828 (+)



Homology
more
  • Human Ortholog
    FOXL2, forkhead box L2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FOXL2, forkhead box L2
  • Synonyms
    BPES, BPES1, PFRK, PINTO, POF3
  • Links
    NCBI Gene ID: 668
    UniProt: P58012

  • Chr Location
    3q22.3; chr3:138944224-138947137 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Foxl2 mouse models; 3 with human FOXL2 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    51 phenotypes from 7 alleles in 9 genetic backgrounds
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display increased postnatal lethality. Of animals surving to mating age, males are fully fertile and females are infertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    66
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1289
  • Tissues
    203
  • cDNA Data
    13
  • Literature Summary
    193
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26927 NCBI Gene Model | MGI Sequence Detail 3107 C57BL/6J ±  kb
    transcript NM_012020 RefSeq | MGI Sequence Detail 3107 C57BL/6  
    polypeptide O88470 UniProt | EBI | MGI Sequence Detail 375 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 15
      Primer pair 17
      Other 5
      Antibodies 20

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2143241
    References
    more
    • Summaries
      All 286
      Developmental Gene Expression 193
      Diseases 3
      Gene Ontology 20
      Phenotypes 61
    • Earliest
      J:48144 Treier M, et al., Multistep signaling requirements for pituitary organogenesis in vivo. Genes Dev. 1998 Jun 1;12(11):1691-704
    • Latest
      J:388801 Das P, et al., NR3C1 is required for normal somatotrope differentiation and Foxo1 expression in pituitary. Endocrinology. 2026 May 26;167(7)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory