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Foxl2
Gene Detail
 Symbol
Name
ID
Foxl2
forkhead box L2
MGI:1349428
Synonyms Pfrk
Feature Type protein coding gene
Genetic Map
Chromosome 9
51.41 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:98955607-98958126 bp, + strand
From NCBI annotation of GRCm38

  2520 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74992  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 chicken; 1 zebrafish

Gene Tree: Foxl2

Human
homologs
Human Homolog FOXL2, forkhead box L2
NCBI Gene ID 668
neXtProt AC  NX_P58012
Human Synonyms  BPES, BPES1, PFRK, PINTO, POF3
Human Chr (Location)  3q23; chr3:138944224-138947140 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human FOXL2
Alleles
and
phenotypes
All alleles(8) : Targeted(8)
 
Mice homozygous for disruptions in this gene display increased postnatal lethality. Of animals surving to mating age, males are fully fertile and females are infertile.
 
Human Diseases Modeled Using Mouse Foxl2 (1)    Alleles Annotated to Human Diseases(2)   
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process apoptotic DNA fragmentation, cell differentiation, ...
Component nucleus, transcription factor complex
Function cysteine-type endopeptidase regulator activity involved in apoptotic process, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (54 records)
Data Summary: Results (116)    Tissues (94)    Images (5)
Theiler Stages: 20, 21, 23, 28
Assay TypeResults
RNA in situ 93
RT-PCR 23
cDNA source data(11)
External Resources: GEO   ArrayExpress
Molecular
reagents
All nucleic(15) cDNA(11) Primer pair(4)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000050397 (Evidence)
Entrez Gene26927 (Evidence)
UniGene151239
NIA Mouse Gene IndexU010899
Consensus CDS ProjectCCDS23430.1
International Mouse Knockout Project StatusFoxl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 26927 NCBI Gene Model | MGI Sequence Detail 2520 C57BL/6J ±  kb
transcript NM_012020 RefSeq | MGI Sequence Detail 2520 Not Specified 
polypeptide O88470 UniProt | EBI | MGI Sequence Detail 375 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(16 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001766 Transcription factor, fork head
InterPro IPR018122 Transcription factor, fork head, conserved site
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007634 forkhead box protein L2
Graphical View of Protein Domain Structure
References (Earliest) J:48144 Treier M, et al., Multistep signaling requirements for pituitary organogenesis in vivo. Genes Dev. 1998 Jun 1;12(11):1691-704
(Latest) J:206011 Zheng W, et al., Two classes of ovarian primordial follicles exhibit distinct developmental dynamics and physiological functions. Hum Mol Genet. 2014 Feb 15;23(4):920-8
All references(97)
Other
accession IDs
MGI:2143241

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory