Phenotypes Associated with This Genotype

Genotype
MGI:8250567

• Allelic Composition: Foxl2^tm1.1Rthi/Foxl2⁺; Amhr2^tm3(cre)Bhr/Amhr2⁺
• Genetic Background: B6.Cg-Foxl2^tm1.1Rthi Amhr2^tm3(cre)Bhr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:369668 )

• fewer than the expected numbers of mice are obtained, with a sex imbalance favoring males, with only 8% of progeny being females

• females develop normally into adulthood

neoplasm

increased granulosa cell tumor incidence ( J:369668 )

♀ • by 12-14 months of age, some females develop unilateral ovarian adult-type granulosa cell tumors ranging from microscopic to grossly visible tumors

endocrine/exocrine glands

increased granulosa cell tumor incidence ( J:369668 )

♀ • by 12-14 months of age, some females develop unilateral ovarian adult-type granulosa cell tumors ranging from microscopic to grossly visible tumors

ovary cyst ( J:369668 )

♀ • females begin to develop cystic uterine changes around 9-10 months of age such that by 10 months of age, all females showed extensive cystic uterine changes

growth/size/body

ovary cyst ( J:369668 )

♀ • females begin to develop cystic uterine changes around 9-10 months of age such that by 10 months of age, all females showed extensive cystic uterine changes

reproductive system

increased granulosa cell tumor incidence ( J:369668 )

♀ • by 12-14 months of age, some females develop unilateral ovarian adult-type granulosa cell tumors ranging from microscopic to grossly visible tumors

ovary cyst ( J:369668 )

♀ • females begin to develop cystic uterine changes around 9-10 months of age such that by 10 months of age, all females showed extensive cystic uterine changes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
granulosa cell tumor		DOID:2999		J:369668