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Sdc2 Gene Detail
Summary
  • Symbol
    Sdc2
  • Name
    syndecan 2
  • Synonyms
    4833414L08Rik, fibroglycan, Hspg1, Synd2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349165
    NCBI Gene: 15529
  • Gene Overview
    MyGene.info: SDC2
Location & Maps
more
  • Sequence Map
    Chr15:32920723-33034730 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      114008 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SDC2, syndecan 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SDC2, syndecan 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD362, HSPG, HSPG1, SYND2
  • Links
    NCBI Gene ID: 6383
    neXtProt AC: NX_P34741

  • Chr Location
    8q22-q23; chr8:96493351-96611809 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2253
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: SDC2
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Sdc2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027993 VEGA Gene Model | MGI Sequence Detail 114008 C57BL/6J ±  kb
transcript OTTMUST00000069337 VEGA | MGI Sequence Detail 3322 Not Applicable  
polypeptide OTTMUSP00000035199 VEGA | MGI Sequence Detail 202 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1165 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 138
    cDNA 135
    Primer pair 2
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-10975, MGD-MRK-14687, MGI:1921849, MGI:2145934, MGI:96256
References
more
  • Summaries
    All 73
    Developmental Gene Expression 23
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:24037 Marynen P, et al., Partial primary structure of the 48- and 90-kilodalton core proteins of cell surface-associated heparan sulfate proteoglycans of lung fibroblasts. Prediction of an integral membrane domain and evidence for multiple distinct core proteins at the cell surfce of human lung fibroblasts. J Biol Chem. 1989 Apr 25;264(12):7017-24
  • Latest
    J:218062 Kim N, et al., Regulation of retinal axon growth by secreted Vax1 homeodomain protein. Elife. 2014;3:e02671

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory