Foxc2
Gene Detail

Symbol Name ID

Foxc2 forkhead box C2 MGI:1347481

Synonyms

Fkh14, Hfhbf3, Mfh1, MFH-1

Feature Type

protein coding gene

Genetic Map

Chromosome 8

70.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr8:121116171-121118892 bp, + strand From Ensembl annotation of GRCm38   2722 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21091  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Foxc2

Human homologs

Human Homolog		FOXC2, forkhead box C2 (MFH-1, mesenchyme forkhead 1)
NCBI Gene ID		2303
neXtProt AC		NX_Q99958
Human Synonyms		FKHL14, LD, MFH1, MFH-1
Human Chr (Location)		16q24.1; chr16:86600857-86602539 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human FOXC2

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Homozygotes for targeted null mutations die perinatally or before with cardiac abnormalities and skeletal defects in the neurocranium and spine. Heterozygotes exhibit lymphatic vessel and lymph node hyperplasia, anterior segment defects, and distichiasis.

 
Human Diseases Modeled Using Mouse Foxc2 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (82 annotations)

Process	artery morphogenesis, blood vessel development, ...
Component	nucleus, transcription factor complex
Function	chromatin DNA binding, DNA binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (57 records)
Data Summary: Results (458)    Tissues (310)    Images (117)
Theiler Stages: 13, 15, 17, 18, 19, 20, 21, 22, 23, 26, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	450
RT-PCR	4

cDNA source data(27)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(36) Genomic(6) cDNA(27) Primer pair(2) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000046714 (Evidence)
Entrez Gene	14234 (Evidence)
UniGene	14092
DFCI	TC1581452
DoTS	DT.481095
Consensus CDS Project	CCDS40499.1
International Mouse Knockout Project Status	Foxc2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000046714	Ensembl Gene Model | MGI Sequence Detail	2722	C57BL/6J
transcript	ENSMUST00000054691	Ensembl | MGI Sequence Detail	2722	Not Applicable
polypeptide	ENSMUSP00000055290	Ensembl | MGI Sequence Detail	494	Not Applicable

All sequences(19) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(3) : SNPs(0 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001766	Transcription factor, fork head
InterPro	IPR018122	Transcription factor, fork head, conserved site
InterPro	IPR011991	Winged helix-turn-helix transcription repressor DNA-binding
Protein Ontology	PR:000007608	forkhead box protein C2

References

(Earliest) J:11921 Sasaki H, et al., Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. Development. 1993 May;118(1):47-59
(Latest) J:188816 Sasman A, et al., Generation of conditional alleles for Foxc1 and Foxc2 in mice. Genesis. 2012 Oct;50(10):766-74
All references(99)

Other accession IDs

MGD-MRK-38305, MGI:109260