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Foxc2
Gene Detail
 Symbol
Name
ID
Foxc2
forkhead box C2
MGI:1347481
Synonyms Fkh14, Hfhbf3, Mfh1, MFH-1
Feature Type protein coding gene
Genetic Map
Chromosome 8
70.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr8:121116171-121118895 bp, + strand
From VEGA annotation of GRCm38

  2725 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21091  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Foxc2

Human
homologs
Human Homolog FOXC2, forkhead box C2 (MFH-1, mesenchyme forkhead 1)
NCBI Gene ID 2303
neXtProt AC  NX_Q99958
Human Synonyms  FKHL14, LD, MFH1, MFH-1
Human Chr (Location)  16q24.1; chr16:86567251-86568933 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human FOXC2
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations die perinatally or before with cardiac abnormalities and skeletal defects in the neurocranium and spine. Heterozygotes exhibit lymphatic vessel and lymph node hyperplasia, anterior segment defects, and distichiasis.
 
Human Diseases Modeled Using Mouse Foxc2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Foxc2 interacts with 123 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (80 annotations)
Process artery morphogenesis, blood vessel development, ...
Component nucleus
Function chromatin DNA binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (64 records)
Data Summary: Results (470)    Tissues (322)    Images (112)
Theiler Stages: 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 462
RT-PCR 4
cDNA source data(28)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(37) Genomic(6) cDNA(28) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000043022 (Evidence)
Ensembl Gene ModelENSMUSG00000046714 (Evidence)
Entrez Gene14234 (Evidence)
UniGene14092
DFCITC1581452
DoTSDT.481095
Consensus CDS ProjectCCDS40499.1
International Mouse Knockout Project StatusFoxc2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043022 VEGA Gene Model | MGI Sequence Detail 2725 C57BL/6J ±  kb
transcript OTTMUST00000112934 VEGA | MGI Sequence Detail 2725 Not Applicable 
polypeptide OTTMUSP00000063255 VEGA | MGI Sequence Detail 494 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(2)
Polymorphisms RFLP(3) : SNPs within 2kb(1 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001766 Transcription factor, fork head
InterPro IPR018122 Transcription factor, fork head, conserved site
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007608 forkhead box protein C2
References (Earliest) J:11921 Sasaki H, et al., Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. Development. 1993 May;118(1):47-59
(Latest) J:209628 Brouillard P, et al., Genetics of lymphatic anomalies. J Clin Invest. 2014 Mar 3;124(3):898-904
All references(109)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-38305, MGI:109260

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory