Automated description from the Alliance of Genome Resources (Release 9.0.0)
Enables DNA-binding transcription factor activity; promoter-specific chromatin binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of vascular wound healing; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including circulatory system development; embryonic morphogenesis; and kidney development. Predicted to be located in nuclear body. Predicted to be active in nucleus. Is expressed in several structures, including cardiovascular system; central nervous system; embryo mesenchyme; limb long bone; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including lymphedema; lymphedema-distichiasis syndrome; obesity; ptosis; and type 2 diabetes mellitus. Orthologous to human FOXC2 (forkhead box C2).
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