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Foxg1 Gene Detail
Summary
  • Symbol
    Foxg1
  • Name
    forkhead box G1
  • Synonyms
    2900064B05Rik, Bf1, BF-1, Hfh9, Hfhbf1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347464
    NCBI Gene: 15228
Location & Maps
more
  • Sequence Map
    Chr12:49382660-49386861 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4202 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    FOXG1, forkhead box G1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    FOXG1, forkhead box G1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BF1, BF2, FHKL3, FKH2, FKHL1, FKHL2, FKHL3, FKHL4, FOXG1A, FOXG1B, FOXG1C, HBF-1, HBF2, HBF-2, HBF-3, HBF-G2, HFK1, HFK2, HFK3, KHL2, QIN
  • Links
    NCBI Gene ID: 2290
    neXtProt AC: NX_P55316

  • Chr Location
    14q13; chr14:28767072-28770277 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human FOXG1 associations

Human Disease Mouse Models
       Rett Syndrome, Congenital Variant   OMIM: 613454
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 3 alleles in 6 genetic backgrounds
    184 phenotypes from multigenic genotypes
    1 images
    186 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit dramatically reduced cerebral hemispheres, missing ventral telencephalic structures, impaired migration of efferent thalamocortical axons, and multiple eye defects. Mutants die at birth from respiratory failure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021132 VEGA Gene Model | MGI Sequence Detail 4202 C57BL/6J ±  kb
transcript OTTMUST00000050035 VEGA | MGI Sequence Detail 3973 Not Applicable  
polypeptide OTTMUSP00000071972 VEGA | MGI Sequence Detail 481 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    7 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007623 forkhead box protein G1
  • InterPro Domains
    IPR001766 Fork head domain
    IPR018122 Fork head domain conserved site1
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 62
    Genomic 4
    cDNA 41
    Primer pair 5
    Other 12

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-16692, MGI:1920272, MGI:99896
References
more
  • Summaries
    All 355
    Developmental Gene Expression 174
    Diseases 4
    Gene Ontology 17
    Phenotypes 186
  • Earliest
    J:20861 Tao W, et al., Telencephalon-restricted expression of BF-1, a new member of the HNF-3/fork head gene family, in the developing rat brain. Neuron. 1992 May;8(5):957-66
  • Latest
    J:224155 You L, et al., The lysine acetyltransferase activator Brpf1 governs dentate gyrus development through neural stem cells and progenitors. PLoS Genet. 2015 Mar;11(3):e1005034

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory