Foxg1
Gene Detail

Symbol Name ID

Foxg1 forkhead box G1 MGI:1347464

Synonyms

2900064B05Rik, Bf1, BF-1, Hfh9, Hfhbf1

Feature Type

protein coding gene

Genetic Map

Chromosome 12

21.78 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr12:49382693-49386856 bp, + strand From VEGA annotation of GRCm38   4164 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle    (Mammalian Orthology)
Comparative Map (Mouse/Human Foxg1 ± 2 cM)

Gene Tree: Foxg1

Human ortholog

FOXG1 forkhead box G1 NCBI Gene ID 2290
Human Synonyms: BF1, BF2, FHKL3, FKH2, FKHL1, FKHL2, FKHL3, FKHL4, FOXG1A, FOXG1B, FOXG1C, HBF-1, HBF2, HBF-2, HBF-3, HBF-G2, HFK1, HFK2, HFK3, KHL2, QIN
Human Chr14:29236287-29238871 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human FOXG1 (1)

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygous mutants exhibit dramatically reduced cerebral hemispheres, missing ventral telencephalic structures, impaired migration of efferent thalamocortical axons, and multiple eye defects. Mutants die at birth from respiratory failure.

 
Human Diseases Modeled Using Mouse Foxg1 (3)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (38 annotations)

Process	axon midline choice point recognition, cell morphogenesis involved in neuron differentiation, ...
Component	nucleus, transcription factor complex
Function	DNA binding, DNA binding, bending, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (155 records)
Data Summary: Results (331)    Tissues (175)    Images (130)
Theiler Stages: 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	285
In situ reporter (knock in)	22
Northern blot	4
Western blot	1
RT-PCR	7
RNase protection	12

cDNA source data(34)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(64) Genomic(4) cDNA(46) Primer pair(5) Other(9)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000021132 (Evidence)
Ensembl Gene Model	ENSMUSG00000020950 (Evidence)
Entrez Gene	15228 (Evidence)
UniGene	4704
DFCI	TC1579366, TC1597462, TC1673836
DoTS	DT.110950307, DT.55200584, DT.60104371, DT.91315732
Consensus CDS Project	CCDS25899.1
International Mouse Knockout Project Status	Foxg1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021132	VEGA Gene Model | MGI Sequence Detail	4164	C57BL/6J
transcript	OTTMUST00000050018	VEGA | MGI Sequence Detail	2936	Not Applicable
polypeptide	OTTMUSP00000023284	VEGA | MGI Sequence Detail	481	Not Applicable

All sequences(37) RefSeq(4) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(0 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001766	Transcription factor, fork head
InterPro	IPR018122	Transcription factor, fork head, conserved site
InterPro	IPR011991	Winged helix-turn-helix transcription repressor DNA-binding
Protein Ontology	PR:000007623	forkhead box protein G1

References

(Earliest) J:20861 Tao W, et al., Telencephalon-restricted expression of BF-1, a new member of the HNF-3/fork head gene family, in the developing rat brain. Neuron. 1992 May;8(5):957-66
(Latest) J:193332 Wang Y, et al., Norrin/Frizzled4 signaling in retinal vascular development and blood brain barrier plasticity. Cell. 2012 Dec 7;151(6):1332-44
All references(300)

Other accession IDs

MGD-MRK-16692, MGI:1920272, MGI:99896