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Foxg1
Gene Detail
 Symbol
Name
ID
Foxg1
forkhead box G1
MGI:1347464
Synonyms 2900064B05Rik, Bf1, BF-1, Hfh9, Hfhbf1
Feature Type protein coding gene
Genetic Map
Chromosome 12
21.78 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr12:49382693-49386856 bp, + strand
From VEGA annotation of GRCm38

  4164 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3843  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 zebrafish

Gene Tree: Foxg1

Human
homologs
Human Homolog FOXG1, forkhead box G1
NCBI Gene ID 2290
neXtProt AC  NX_P55316
Human Synonyms  BF1, BF2, FHKL3, FKH2, FKHL1, FKHL2, FKHL3, FKHL4, FOXG1A, FOXG1B, FOXG1C, HBF-1, HBF2, HBF-2, HBF-3, HBF-G2, HFK1, HFK2, HFK3, KHL2, QIN
Human Chr (Location)  14q13; chr14:28767072-28770277 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human FOXG1
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants exhibit dramatically reduced cerebral hemispheres, missing ventral telencephalic structures, impaired migration of efferent thalamocortical axons, and multiple eye defects. Mutants die at birth from respiratory failure.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Foxg1 interacts with 299 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process axon midline choice point recognition, cell morphogenesis involved in neuron differentiation, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (163 records)
Data Summary: Results (336)    Tissues (176)    Images (132)
Theiler Stages: 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 290
In situ reporter (knock in) 22
Northern blot 4
Western blot 1
RT-PCR 7
RNase protection 12
cDNA source data(27)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(58) Genomic(4) cDNA(39) Primer pair(5) Other(10)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021132 (Evidence)
Ensembl Gene ModelENSMUSG00000020950 (Evidence)
Entrez Gene15228 (Evidence)
UniGene4704
DFCITC1579366, TC1597462, TC1673836
DoTSDT.110950307, DT.55200584, DT.60104371, DT.91315732
Consensus CDS ProjectCCDS25899.1
International Mouse Knockout Project StatusFoxg1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021132 VEGA Gene Model | MGI Sequence Detail 4164 C57BL/6J ±  kb
transcript OTTMUST00000050018 VEGA | MGI Sequence Detail 2936 Not Applicable 
polypeptide OTTMUSP00000023284 VEGA | MGI Sequence Detail 481 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(4) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(7 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001766 Transcription factor, fork head
InterPro IPR018122 Transcription factor, fork head, conserved site
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007623 forkhead box protein G1
References (Earliest) J:20861 Tao W, et al., Telencephalon-restricted expression of BF-1, a new member of the HNF-3/fork head gene family, in the developing rat brain. Neuron. 1992 May;8(5):957-66
(Latest) J:207496 Symmons O, et al., Functional and topological characteristics of mammalian regulatory domains. Genome Res. 2014 Mar;24(3):390-400
All references(328)
Other
accession IDs
MGD-MRK-16692, MGI:1920272, MGI:99896

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory