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Foxg1 Gene Detail
Summary
  • Symbol
    Foxg1
  • Name
    forkhead box G1
  • Synonyms
    2900064B05Rik, Bf1, BF-1, Hfh9, Hfhbf1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347464
    NCBI Gene: 15228
  • Gene Overview
    MyGene.info: FOXG1
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:49382883-49386867 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 21.78 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347464
protein coding gene Chr12:49382660-49386867 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019717
protein coding gene Chr12:48107306-48111453 (+)
A/J MGP_AJ_G0019680
protein coding gene Chr12:46402739-46406901 (+)
AKR/J MGP_AKRJ_G0019651
protein coding gene Chr12:47774597-47778781 (+)
BALB/cJ MGP_BALBcJ_G0019658
protein coding gene Chr12:46660378-46664580 (+)
C3H/HeJ MGP_C3HHeJ_G0019461
protein coding gene Chr12:47880478-47884610 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020104
protein coding gene Chr12:49549399-49553545 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017729
protein coding gene Chr12:44995331-44999484 (+)
CAST/EiJ MGP_CASTEiJ_G0019014
protein coding gene Chr12:42946078-42950099 (+)
CBA/J MGP_CBAJ_G0019433
protein coding gene Chr12:51254029-51258159 (+)
DBA/2J MGP_DBA2J_G0019547
protein coding gene Chr12:46251447-46255592 (+)
FVB/NJ MGP_FVBNJ_G0019536
protein coding gene Chr12:45752391-45756553 (+)
LP/J MGP_LPJ_G0019616
protein coding gene Chr12:48117035-48121587 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019572
protein coding gene Chr12:52694225-52699493 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020144
protein coding gene Chr12:47332846-47337009 (+)
PWK/PhJ MGP_PWKPhJ_G0018781
protein coding gene Chr12:40830168-40834568 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018573
protein coding gene Chr12:41898725-41902859 (+)
WSB/EiJ MGP_WSBEiJ_G0019064
protein coding gene Chr12:47749042-47753180 (+)



Homology
more
  • Human Ortholog
    FOXG1, forkhead box G1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    FOXG1, forkhead box G1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BF1, BF2, FHKL3, FKH2, FKHL1, FKHL2, FKHL3, FKHL4, FOXG1A, FOXG1B, FOXG1C, HBF-1, HBF2, HBF-2, HBF-3, HBF-G2, HFK1, HFK2, HFK3, KHL2, QIN
  • Links
    NCBI Gene ID: 2290
    neXtProt AC: NX_P55316
    UniProt: P55316

  • Chr Location
    14q12; chr14:28767072-28770277 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Foxg1 mouse models; 1 with human FOXG1 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    37 phenotypes from 3 alleles in 7 genetic backgrounds
    219 phenotypes from multigenic genotypes
    2 images
    237 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit dramatically reduced cerebral hemispheres, missing ventral telencephalic structures, impaired migration of efferent thalamocortical axons, and multiple eye defects. Mutants die at birth from respiratory failure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15228 NCBI Gene Model | MGI Sequence Detail 3985 C57BL/6J ±  kb
    transcript NM_001160112 RefSeq | MGI Sequence Detail 3986 C57BL/6  
    polypeptide Q60987 UniProt | EBI | MGI Sequence Detail 481 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 64
      Genomic 4
      cDNA 41
      Primer pair 5
      Other 14

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16692, MGI:1920272, MGI:99896
    References
    more
    • Summaries
      All 422
      Developmental Gene Expression 191
      Diseases 6
      Gene Ontology 18
      Phenotypes 237
    • Earliest
      J:20861 Tao W, et al., Telencephalon-restricted expression of BF-1, a new member of the HNF-3/fork head gene family, in the developing rat brain. Neuron. 1992 May;8(5):957-66
    • Latest
      J:265822 Chapman H, et al., Gsx transcription factors control neuronal versus glial specification in ventricular zone progenitors of the mouse lateral ganglionic eminence. Dev Biol. 2018 Oct 1;442(1):115-126

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory