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Foxg1 Gene Detail
Summary
  • Symbol
    Foxg1
  • Name
    forkhead box G1
  • Synonyms
    2900064B05Rik, Bf1, BF-1, Hfh9, Hfhbf1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347464
    NCBI Gene: 15228
  • Gene Overview
    MyGene.info: FOXG1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr12:49382660-49386861 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4202 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 21.78 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    FOXG1, forkhead box G1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    FOXG1, forkhead box G1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BF1, BF2, FHKL3, FKH2, FKHL1, FKHL2, FKHL3, FKHL4, FOXG1A, FOXG1B, FOXG1C, HBF-1, HBF2, HBF-2, HBF-3, HBF-G2, HFK1, HFK2, HFK3, KHL2, QIN
  • Links
    NCBI Gene ID: 2290
    neXtProt AC: NX_P55316
    UniProt: P55316

  • Chr Location
    14q12; chr14:28767072-28770277 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Foxg1 mouse models; 1 with human FOXG1 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    37 phenotypes from 3 alleles in 7 genetic backgrounds
    195 phenotypes from multigenic genotypes
    2 images
    227 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit dramatically reduced cerebral hemispheres, missing ventral telencephalic structures, impaired migration of efferent thalamocortical axons, and multiple eye defects. Mutants die at birth from respiratory failure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000021132 VEGA Gene Model | MGI Sequence Detail 4202 C57BL/6J ±  kb
    transcript OTTMUST00000050035 VEGA | MGI Sequence Detail 3973 Not Applicable  
    polypeptide OTTMUSP00000071972 VEGA | MGI Sequence Detail 481 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      7 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 63
      Genomic 4
      cDNA 41
      Primer pair 5
      Other 13

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16692, MGI:1920272, MGI:99896
    References
    more
    • Summaries
      All 413
      Developmental Gene Expression 189
      Diseases 5
      Gene Ontology 19
      Phenotypes 227
    • Earliest
      J:20861 Tao W, et al., Telencephalon-restricted expression of BF-1, a new member of the HNF-3/fork head gene family, in the developing rat brain. Neuron. 1992 May;8(5):957-66
    • Latest
      J:257918 Massimino L, et al., TBR2 antagonizes retinoic acid dependent neuronal differentiation by repressing Zfp423 during corticogenesis. Dev Biol. 2018 Feb 15;434(2):231-248

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory