Adamts2
Gene Detail

Symbol Name ID

Adamts2 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2 MGI:1347356

Synonyms

ADAM-TS2, a disintegrin and metalloproteinase with thrombospondin repeats, hPCPNI, procollagen N-proteinase

Feature Type

protein coding gene

Genetic Map

Chromosome 11

30.78 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:50602084-50807573 bp, + strand From VEGA annotation of GRCm38   205490 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8597  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Adamts2

Human homologs

Human Homolog		ADAMTS2, ADAM metallopeptidase with thrombospondin type 1 motif, 2
NCBI Gene ID		9509
neXtProt AC		NX_O95450
Human Synonyms		ADAM-TS2, ADAMTS-2, ADAMTS-3, NPI, PCINP, PC I-NP, PCI-NP, PCPNI, PNPI
Human Chr (Location)		5qter; chr5:178537852-178772431 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ADAMTS2

Alleles and phenotypes

All alleles(5) : Targeted(2) Gene trapped(3)
 

Homozygous mutation of this gene results in a short snout, male infertility, and thin skin that is torn by scratching or handling.

 
Human Diseases Modeled Using Mouse Adamts2 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	collagen catabolic process, collagen fibril organization, ...
Component	extracellular matrix, extracellular region, ...
Function	hydrolase activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (35)    Tissues (35)    Images (4)
Theiler Stages: 11, 19, 20, 22, 24

Assay Type	Results
RNA in situ	34
RT-PCR	1

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000005590 (Evidence)
Ensembl Gene Model	ENSMUSG00000036545 (Evidence)
Entrez Gene	216725 (Evidence)
DFCI	TC1583677, TC1598160, TC1659438
DoTS	DT.101305803, DT.101722073, DT.91335976
NIA Mouse Gene Index	U012554, U012555
EC	3.4.24.14
Consensus CDS Project	CCDS24636.1
International Mouse Knockout Project Status	Adamts2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005590	VEGA Gene Model | MGI Sequence Detail	205490	C57BL/6J
transcript	OTTMUST00000012439	VEGA | MGI Sequence Detail	7266	Not Applicable
polypeptide	OTTMUSP00000005749	VEGA | MGI Sequence Detail	1213	Not Applicable

All sequences(41) RefSeq(4) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(731 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR010294	ADAM-TS Spacer 1
InterPro	IPR024079	Metallopeptidase, catalytic domain
InterPro	IPR001590	Peptidase M12B, ADAM/reprolysin
InterPro	IPR013273	Peptidase M12B, ADAM-TS
InterPro	IPR013275	Peptidase M12B, ADAM-TS2
InterPro	IPR002870	Peptidase M12B, propeptide
InterPro	IPR010909	PLAC
InterPro	IPR000884	Thrombospondin, type 1 repeat
Protein Ontology	PR:000003730	A disintegrin and metalloproteinase with thrombospondin motifs 2

References

(Earliest) J:57247 Hurskainen TL, et al., ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family. J Biol Chem. 1999 Sep 3;274(36):25555-63
(Latest) J:165751 Du J, et al., O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Dev Biol. 2010 Oct 1;346(1):25-38
All references(32)