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Adamts2
Gene Detail
 Symbol
Name
ID
Adamts2
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2
MGI:1347356
Synonyms ADAM-TS2, a disintegrin and metalloproteinase with thrombospondin repeats, hPCPNI, procollagen N-proteinase
Feature Type protein coding gene
Genetic Map
Chromosome 11
30.78 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:50602084-50807573 bp, + strand
From VEGA annotation of GRCm38

  205490 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8597  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Adamts2

Human
homologs
Human Homolog ADAMTS2, ADAM metallopeptidase with thrombospondin type 1 motif, 2
NCBI Gene ID 9509
neXtProt AC  NX_O95450
Human Synonyms  ADAM-TS2, ADAMTS-2, ADAMTS-3, NPI, PCINP, PC I-NP, PCI-NP, PCPNI, PNPI
Human Chr (Location)  5qter; chr5:179110851-179345430 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ADAMTS2
Alleles
and
phenotypes
All alleles(5) : Targeted(2) Gene trapped(3)
 
Homozygous mutation of this gene results in a short snout, male infertility, and thin skin that is torn by scratching or handling.
 
Human Diseases Modeled Using Mouse Adamts2 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process collagen catabolic process, collagen fibril organization, ...
Component extracellular matrix, extracellular region, ...
Function hydrolase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (35)    Tissues (35)    Images (4)
Theiler Stages: 11, 19, 20, 22, 24
Assay TypeResults
RNA in situ 34
RT-PCR 1
cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000005590 (Evidence)
Ensembl Gene ModelENSMUSG00000036545 (Evidence)
Entrez Gene216725 (Evidence)
DFCITC1583677, TC1598160, TC1659438
DoTSDT.101305803, DT.101722073, DT.91335976
NIA Mouse Gene IndexU012554, U012555
EC3.4.24.14
Consensus CDS ProjectCCDS24636.1
International Mouse Knockout Project StatusAdamts2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005590 VEGA Gene Model | MGI Sequence Detail 205490 C57BL/6J ±  kb
transcript OTTMUST00000012439 VEGA | MGI Sequence Detail 7266 Not Applicable 
polypeptide OTTMUSP00000005749 VEGA | MGI Sequence Detail 1213 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(4) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(1088 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1090)
Protein-related
information
ResourceIDDescription
InterPro IPR010294 ADAM-TS Spacer 1
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR001590 Peptidase M12B, ADAM/reprolysin
InterPro IPR013273 Peptidase M12B, ADAM-TS
InterPro IPR013275 Peptidase M12B, ADAM-TS2
InterPro IPR002870 Peptidase M12B, propeptide
InterPro IPR010909 PLAC
InterPro IPR000884 Thrombospondin, type 1 repeat
Protein Ontology PR:000003730 A disintegrin and metalloproteinase with thrombospondin motifs 2
References (Earliest) J:57247 Hurskainen TL, et al., ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family. J Biol Chem. 1999 Sep 3;274(36):25555-63
(Latest) J:165751 Du J, et al., O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Dev Biol. 2010 Oct 1;346(1):25-38
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory