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Adamts2
Gene Detail
Symbol

Name
ID
Adamts2
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2
MGI:1347356
Synonyms
ADAM-TS2, a disintegrin and metalloproteinase with thrombospondin repeats, hPCPNI, procollagen N-proteinase
Feature Type
protein coding gene
Genetic Map
Chromosome 11
30.78 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:50602084-50807573 bp, + strand
From VEGA annotation of GRCm38

  205490 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8597  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ADAMTS2
Gene Tree: Adamts2

Human
homologs
ADAMTS2, ADAM metallopeptidase with thrombospondin type 1 motif, 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9509
neXtProt AC: NX_O95450

Human Synonyms: ADAM-TS2, ADAMTS-2, ADAMTS-3, NPI, PCINP, PC I-NP, PCI-NP, PCPNI, PNPI

Human Chr (Location): 5qter; chr5:179110851-179345430 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ADAMTS2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(3) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in a short snout, male infertility, and thin skin that is torn by scratching or handling.
 
Human Diseases Modeled in Mice Using Adamts2 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Adamts2 interacts with 333 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process collagen catabolic process, collagen fibril organization, ...
Component extracellular matrix, extracellular region, ...
Function hydrolase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (35)    Tissues (35)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 34
RT-PCR 1
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ADAMTS2 ; Xenbase adamts2 ; ZFIN adamts2    NEW 
Molecular
reagents
All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000005590 (Evidence)
Ensembl Gene Model ENSMUSG00000036545 (Evidence)
Entrez Gene 216725 (Evidence)
DFCI TC1583677, TC1598160, TC1659438
DoTS DT.101305803, DT.101722073, DT.91335976
NIA Mouse Gene Index U012554, U012555
EC 3.4.24.14
Consensus CDS Project CCDS24636.1
International Mouse Phenotyping Consortium Status Adamts2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005590 VEGA Gene Model | MGI Sequence Detail 205490 C57BL/6J ±  kb
transcript OTTMUST00000012439 VEGA | MGI Sequence Detail 7266 Not Applicable 
polypeptide OTTMUSP00000005749 VEGA | MGI Sequence Detail 1213 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(6) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(1088 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1090)
Protein-related
information
ResourceIDDescription
InterPro IPR010294 ADAM-TS Spacer 1
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR001590 Peptidase M12B, ADAM/reprolysin
InterPro IPR013273 Peptidase M12B, ADAM-TS
InterPro IPR013275 Peptidase M12B, ADAM-TS2
InterPro IPR002870 Peptidase M12B, propeptide
InterPro IPR010909 PLAC
InterPro IPR000884 Thrombospondin, type 1 repeat
Protein Ontology PR:000003730 a disintegrin and metalloproteinase with thrombospondin motifs 2
References
(Earliest) J:57247 Hurskainen TL, et al., ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family. J Biol Chem. 1999 Sep 3;274(36):25555-63
(Latest) J:206605 Faisal M, et al., Sexual differences of imprinted genes' expression levels. Gene. 2014 Jan 1;533(1):434-8
All references(31)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory