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Adamts2 Gene Detail
Summary
  • Symbol
    Adamts2
  • Name
    a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2
  • Synonyms
    ADAM-TS2, a disintegrin and metalloproteinase with thrombospondin repeats, hPCPNI, procollagen N-proteinase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347356
    NCBI Gene: 216725
  • Gene Overview
    MyGene.info: ADAMTS2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:50602085-50807573 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 30.78 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1086 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347356
protein coding gene Chr11:50602084-50807573 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018251
protein coding gene Chr11:49786738-49999665 (+)
A/J MGP_AJ_G0018219
protein coding gene Chr11:47885813-48091639 (+)
AKR/J MGP_AKRJ_G0018189
protein coding gene Chr11:49394001-49604726 (+)
BALB/cJ MGP_BALBcJ_G0018189
protein coding gene Chr11:48167325-48378611 (+)
C3H/HeJ MGP_C3HHeJ_G0018002
protein coding gene Chr11:49389375-49601663 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018640
protein coding gene Chr11:51253944-51466739 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016293
protein coding gene Chr11:45487396-45692271 (+)
CAST/EiJ MGP_CASTEiJ_G0017564
protein coding gene Chr11:49398368-49616865 (+)
CBA/J MGP_CBAJ_G0017977
protein coding gene Chr11:53626795-53857696 (+)
DBA/2J MGP_DBA2J_G0018084
protein coding gene Chr11:47665477-47877499 (+)
FVB/NJ MGP_FVBNJ_G0018078
protein coding gene Chr11:47304786-47514439 (+)
LP/J MGP_LPJ_G0018159
protein coding gene Chr11:50155212-50368005 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018103
protein coding gene Chr11:55141397-55353301 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018684
protein coding gene Chr11:49500380-49708803 (+)
PWK/PhJ MGP_PWKPhJ_G0017342
protein coding gene Chr11:48073840-48279495 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017137
protein coding gene Chr11:49214775-49431207 (+)
WSB/EiJ MGP_WSBEiJ_G0017617
protein coding gene Chr11:49137457-49351360 (+)



Homology
more
  • Human Ortholog
    ADAMTS2, ADAM metallopeptidase with thrombospondin type 1 motif 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ADAMTS2, ADAM metallopeptidase with thrombospondin type 1 motif 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ADAM-TS2, ADAMTS-2, ADAMTS-3, EDSDERMS, NPI, PCINP, PC I-NP, PCI-NP, PCPNI, PNPI
  • Links
    NCBI Gene ID: 9509
    neXtProt AC: NX_O95450
    UniProt: O95450

  • Chr Location
    5q35.3; chr5:179110851-179345430 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in a short snout, male infertility, and thin skin that is torn by scratching or handling.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 216725 NCBI Gene Model | MGI Sequence Detail 205489 C57BL/6J ±  kb
    transcript NM_175643 RefSeq | MGI Sequence Detail 7265 C57BL/6  
    polypeptide Q8C9W3 UniProt | EBI | MGI Sequence Detail 1213 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:239267 Bekhouche M, et al., Determination of the substrate repertoire of ADAMTS2, 3, and 14 significantly broadens their functions and identifies extracellular matrix organization and TGF-beta signaling as primary targets. FASEB J. 2016 May;30(5):1741-56

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory