Adamts2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Adamts2
ADAM metallopeptidase with thrombospondin type 1 motif 2
MGI:1347356

24 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Adamts14^{Gt(511E11)Cmhd}/Adamts14^{Gt(511E11)Cmhd} Adamts2^tm1Prc/Adamts2^tm1Prc involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal cutaneous collagen fibril morphology	J:271185
	abnormal homeostasis	J:271185
	abnormal T cell activation	J:271185
	abnormal tendon collagen fibril morphology	J:271185
	cutaneous mastocytosis	J:271185
	decreased B cell number	J:271185
	decreased CD8-positive, alpha-beta T cell number	J:271185
	decreased skin tensile strength	J:271185
	dermal hyperplasia	J:271185
	dermatitis	J:271185
	normal homeostasis/metabolism phenotype	J:271185
	increased CD4-positive, alpha-beta T cell number	J:271185
	increased interferon-gamma secretion	J:271185
	increased interleukin-2 secretion	J:271185
	increased keratinocyte apoptosis	J:271185
	increased keratinocyte proliferation	J:271185
	increased T cell proliferation	J:271185
	normal integument phenotype	J:271185
	male infertility	J:271185
	mixed cellular infiltration to dermis	J:271185
	ruffled hair	J:271185
	spontaneous skin ulceration	J:271185
	thick epidermis	J:271185
	normal vision/eye phenotype	J:271185

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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