Adamts2^tm1Prc
Targeted Allele Detail

Summary

• Symbol: Adamts2^tm1Prc
• Name: ADAM metallopeptidase with thrombospondin type 1 motif 2; targeted mutation 1, Darwin J Prockop
• MGI ID: MGI:2388161
• Gene: Adamts2 Location: Chr11:50492912-50698400 bp, + strand Genetic Position: Chr11, 30.78 cM
• Alliance: Adamts2^tm1Prc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69141
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 14 and flanking intronic sequences with a neomycin resistance cassette. Northern blot analysis of fibroblasts from homozygous mutant animals did not detect RNA transcripts of any size. (J:69141)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adamts2 Mutation: 57 strains or lines available

References

• Original: J:69141 Li SW, et al., Transgenic mice with inactive alleles for procollagen N-proteinase (ADAMTS-2) develop fragile skin and male sterility. Biochem J. 2001 Apr 15;355(Pt 2):271-8
• All: 6 reference(s)