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Abcg2
Gene Detail
Symbol

Name
ID
Abcg2
ATP-binding cassette, sub-family G (WHITE), member 2
MGI:1347061
Synonyms
Bcrp
Feature Type
protein coding gene
Genetic Map
Chromosome 6
27.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:58584523-58692869 bp, + strand
From VEGA annotation of GRCm38

  108347 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55852  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ABCG2
Gene Tree: Abcg2

Human
homologs
ABCG2, ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9429
neXtProt AC: NX_Q9UNQ0

Human Synonyms: ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, MXR-1, UAQTL1

Human Chr (Location): 4q22; chr4:88090264-88231417 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(62) : Gene trapped(53) Targeted(9)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice exhibit extreme sensitivity to the dietary chlorophyll-catabolite pheophorbide a, resulting in severe phototoxic skin lesions upon light exposure. Mutants show a novel form of protoporphyria, associated with a 10-fold increase in erythrocyte levels of protoporphyrin IX.
 
Human Diseases Modeled in Mice Using Abcg2 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Abcg2 interacts with 63 markers (Mir17, Mir20a, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process drug export, drug transmembrane transport, ...
Component apical plasma membrane, integral component of membrane, ...
Function ATPase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (127)    Tissues (123)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 17
RNA in situ 102
Western blot 2
RT-PCR 6
cDNA source data(31)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase abcg2    NEW 
Molecular
reagents
All nucleic(35) cDNA(31) Primer pair(3) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000022209 (Evidence)
Ensembl Gene Model ENSMUSG00000029802 (Evidence)
Entrez Gene 26357 (Evidence)
UniGene 333096
DFCI TC1584714, TC1618389, TC1647598, TC1662546, TC1698526, TC1717804
DoTS DT.101365361, DT.110480578, DT.489480, DT.87051115, DT.94206292, DT.94293047
NIA Mouse Gene Index U006937
Consensus CDS Project CCDS20195.1
International Mouse Phenotyping Consortium Status Abcg2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022209 VEGA Gene Model | MGI Sequence Detail 108347 C57BL/6J ±  kb
transcript OTTMUST00000052779 VEGA | MGI Sequence Detail 2492 Not Applicable 
polypeptide OTTMUSP00000025071 VEGA | MGI Sequence Detail 657 Not Applicable 

For the selected sequences
All sequences(101) RefSeq(12) UniProt(9)
Polymorphisms
SNPs within 2kb(571 from dbSNP Build 137)    SNPs within 2kb including multiple locations(577)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR013525 ABC-2 type transporter
InterPro IPR003439 ABC transporter-like
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000001283 ATP-binding cassette sub-family G member 2
References
(Earliest) J:56609 Allikmets R, et al., A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance. Cancer Res. 1998 Dec 1;58(23):5337-9
(Latest) J:223114 Marriott S, et al., ABCG2pos lung mesenchymal stem cells are a novel pericyte subpopulation that contributes to fibrotic remodeling. Am J Physiol Cell Physiol. 2014 Oct 15;307(8):C684-98
All references(90)
Disease annotation references (1)
Other
accession IDs
MGI:2141405

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory