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Abcg2
Gene Detail
Symbol

Name
ID
Abcg2
ATP-binding cassette, sub-family G (WHITE), member 2
MGI:1347061
Synonyms
Bcrp
Feature Type
protein coding gene
Genetic Map
Chromosome 6
27.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:58584523-58692869 bp, + strand
From VEGA annotation of GRCm38

  108347 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55852  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Abcg2

Human
homologs
Human Homolog ABCG2, ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
NCBI Gene ID 9429
neXtProt AC  NX_Q9UNQ0
Human Synonyms  ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1
Human Chr (Location)  4q22; chr4:88090264-88231417 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(62) : Gene trapped(53) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit extreme sensitivity to the dietary chlorophyll-catabolite pheophorbide a, resulting in severe phototoxic skin lesions upon light exposure. Mutants show a novel form of protoporphyria, associated with a 10-fold increase in erythrocyte levels of protoporphyrin IX.
 
Human Diseases Modeled Using Mouse Abcg2 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Abcg2 interacts with 63 markers (Mir17, Mir20a, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process drug export, drug transmembrane transport, ...
Component apical plasma membrane, integral component of membrane, ...
Function ATPase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (127)    Tissues (123)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 17
RNA in situ 102
Western blot 2
RT-PCR 6
cDNA source data(31)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(35) cDNA(31) Primer pair(3) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000022209 (Evidence)
Ensembl Gene ModelENSMUSG00000029802 (Evidence)
Entrez Gene26357 (Evidence)
UniGene333096
DFCITC1647598, TC1618389, TC1584714, TC1662546, TC1717804, TC1698526
DoTSDT.101365361, DT.110480578, DT.489480, DT.94206292, DT.87051115, DT.94293047
NIA Mouse Gene IndexU006937
Consensus CDS ProjectCCDS20195.1
International Mouse Knockout Project StatusAbcg2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022209 VEGA Gene Model | MGI Sequence Detail 108347 C57BL/6J ±  kb
transcript OTTMUST00000052779 VEGA | MGI Sequence Detail 2492 Not Applicable 
polypeptide OTTMUSP00000025071 VEGA | MGI Sequence Detail 657 Not Applicable 

For the selected sequences
All sequences(93) RefSeq(10) UniProt(17)
Polymorphisms
SNPs within 2kb(571 from dbSNP Build 137)    SNPs within 2kb including multiple locations(577)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR013525 ABC-2 type transporter
InterPro IPR003439 ABC transporter-like
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000001283 ATP-binding cassette sub-family G member 2
References
(Earliest) J:56609 Allikmets R, et al., A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance. Cancer Res. 1998 Dec 1;58(23):5337-9
(Latest) J:213129 Maher TJ, et al., ATP-binding cassette transporter Abcg2 lineage contributes to the cardiac vasculature after oxidative stress. Am J Physiol Heart Circ Physiol. 2014 Jun 15;306(12):H1610-8
All references(87)
Disease annotation references (1)
Other
accession IDs
MGI:2141405

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory