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Abcg2 Gene Detail
Summary
  • Symbol
    Abcg2
  • Name
    ATP-binding cassette, sub-family G (WHITE), member 2
  • Synonyms
    Bcrp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347061
    NCBI Gene: 26357
  • Gene Overview
    MyGene.info: ABCG2
Location & Maps
more
  • Sequence Map
    Chr6:58584523-58695676 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      111154 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 27.82 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ABCG2, ATP binding cassette subfamily G member 2 (Junior blood group)
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ABCG2, ATP binding cassette subfamily G member 2 (Junior blood group)
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, MXR-1, UAQTL1
  • Links
    NCBI Gene ID: 9429
    neXtProt AC: NX_Q9UNQ0

  • Chr Location
    4q22; chr4:88090264-88231417 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 55852
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: ABCG2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Abcg2 mouse models

Human Disease Mouse Models
       Protoporphyria, Erythropoietic; EPP   OMIM: 177000 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 5 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit extreme sensitivity to the dietary chlorophyll-catabolite pheophorbide a, resulting in severe phototoxic skin lesions upon light exposure. Mutants show a novel form of protoporphyria, associated with a 10-fold increase in erythrocyte levels of protoporphyrin IX.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022209 VEGA Gene Model | MGI Sequence Detail 111154 C57BL/6J ±  kb
transcript OTTMUST00000052779 VEGA | MGI Sequence Detail 5717 Not Applicable  
polypeptide OTTMUSP00000025071 VEGA | MGI Sequence Detail 657 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    559 from dbSNP Build 142
Protein
Information
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  • UniProt
    11 Sequences
  • Protein Ontology
    PR:000001283 ATP-binding cassette sub-family G member 2
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR013525 ABC-2 type transporter
    IPR003439 ABC transporter-like
    IPR030256 ATP-binding cassette subfamily G member 2
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 35
    cDNA 31
    Primer pair 3
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2141405
References
more
  • Summaries
    All 93
    Developmental Gene Expression 10
    Diseases 1
    Gene Ontology 6
    Phenotypes 50
  • Earliest
    J:56609 Allikmets R, et al., A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance. Cancer Res. 1998 Dec 1;58(23):5337-9
  • Latest
    J:227211 Zhang Y, et al., Maternal bile acid transporter deficiency promotes neonatal demise. Nat Commun. 2015;6:8186

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory