Abcg2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Abcg2
ATP binding cassette subfamily G member 2 (Junior blood group)
MGI:1347061

40 phenotypes from 6 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Abcg2^em1Omw/Abcg2^em1Omw C57BL/6J-Abcg2^em1Omw	abnormal intestine physiology	J:292268
	abnormal kidney physiology	J:292268
	decreased renal glomerular filtration rate	J:292268
	hepatic steatosis	J:292268
	increased blood uric acid level	J:292268
	increased circulating glucose level	J:292268
	increased circulating insulin level	J:292268
	increased circulating insulin-like growth factor I level	J:292268
	increased circulating potassium level	J:292268
	increased urine osmolality	J:292268
	increased urine sodium level	J:292268
Abcg2^{tm1.1(KOMP)Vlcg}/Abcg2⁺ B6N(Cg)-Abcg2^{tm1.1(KOMP)Vlcg}/J	fused cornea and lens	J:211773
Abcg2^{tm1.1(KOMP)Vlcg}/Abcg2^{tm1.1(KOMP)Vlcg} B6N(Cg)-Abcg2^{tm1.1(KOMP)Vlcg}/J	decreased blood urea nitrogen level	J:211773
	increased circulating cholesterol level	J:211773
	increased circulating HDL cholesterol level	J:211773
Abcg2^tm1.1Ssf/Abcg2^tm1.1Ssf involves: 129 * C57BL/6 * FVB	abnormal bone marrow cell morphology/development	J:201884
	abnormal endoplasmic reticulum morphology	J:201884
	abnormal glucose homeostasis	J:201884
	abnormal hepatocyte mitochondrial morphology	J:201884
	abnormal hepatocyte morphology	J:201884
	abnormal mitochondrial crista morphology	J:201884
	abnormal mitochondrial physiology	J:201884
	abnormal oxidative phosphorylation	J:201884
	abnormal respiratory electron transport chain	J:201884
	decreased liver glycogen level	J:201884
	impaired glucose tolerance	J:201884
	increased porphyrin level	J:201884
	liver inflammation	J:201884
	oxidative stress	J:201884
Abcg2^tm1Ahs/Abcg2^tm1Ahs either: (involves: 129P2/OlaHsd * FVB) or (involves: FVB)	abnormal bile color	J:80519
	normal hematopoietic system phenotype	J:80519
	normal homeostasis/metabolism phenotype	J:80519
	increased circulating bilirubin level	J:80519
	phototoxicity	J:80519
	porphyria	J:80519
Abcg2^tm1Ahs/Abcg2^tm1Ahs FVB.129P2-Abcg2^tm1Ahs/Tac	abnormal homeostasis	J:220924
	increased blood uric acid level	J:220924
	increased urine uric acid level	J:220924
Abcg2^tm1Bsor/Abcg2^tm1Bsor involves: 129P2/OlaHsd * C57BL/6	abnormal hematopoietic system morphology/development	J:98134
	increased physiological sensitivity to xenobiotic	J:98134
Abcg2^{tm3.1(cre/ERT2)Bsor}/Abcg2⁺ involves: 129 * C57BL/6J	no abnormal phenotype detected	J:189206

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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