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Map3k7 Gene Detail
Summary
  • Symbol
    Map3k7
  • Name
    mitogen-activated protein kinase kinase kinase 7
  • Synonyms
    Tak1, TAK1, TGF-beta activated kinase 1, transforming growth factor beta-activated kinase 1, transforming growth factor-beta-activated kinase 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346877
    NCBI Gene: 26409
  • Gene Overview
    MyGene.info: MAP3K7
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:31964097-32023467 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 13.91 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    648 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346877
protein coding gene Chr4:31963395-32023470 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028108
protein coding gene Chr4:29409329-29467594 (+)
A/J MGP_AJ_G0028066
protein coding gene Chr4:28368379-28426260 (+)
AKR/J MGP_AKRJ_G0028030
protein coding gene Chr4:29108989-29167210 (+)
BALB/cJ MGP_BALBcJ_G0028077
protein coding gene Chr4:28607913-28670554 (+)
C3H/HeJ MGP_C3HHeJ_G0027807
protein coding gene Chr4:29388344-29447036 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028519
protein coding gene Chr4:30579309-30638593 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025861
protein coding gene Chr4:26421995-26478312 (+)
CAST/EiJ MGP_CASTEiJ_G0027261
protein coding gene Chr4:29150200-29208674 (+)
CBA/J MGP_CBAJ_G0027779
protein coding gene Chr4:31546020-31607338 (+)
DBA/2J MGP_DBA2J_G0027923
protein coding gene Chr4:28372230-28438508 (+)
FVB/NJ MGP_FVBNJ_G0027888
protein coding gene Chr4:27802897-27860258 (+)
LP/J MGP_LPJ_G0028031
protein coding gene Chr4:29495040-29554302 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027921
protein coding gene Chr4:34182458-34240632 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028578
protein coding gene Chr4:29110279-29168486 (+)
PWK/PhJ MGP_PWKPhJ_G0026981
protein coding gene Chr4:28323617-28382750 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026809
protein coding gene Chr4:28961634-29021223 (+)
WSB/EiJ MGP_WSBEiJ_G0027338
protein coding gene Chr4:29110111-29168952 (+)



Homology
more
  • Human Ortholog
    MAP3K7, mitogen-activated protein kinase kinase kinase 7
  • Vertebrate Orthologs
    3
  • Human Ortholog
    MAP3K7, mitogen-activated protein kinase kinase kinase 7
    Orthology source: HGNC
  • Synonyms
    CSCF, FMD2, MEKK7, TAK1, TGF1a
  • Links
    NCBI Gene ID: 6885
    neXtProt AC: NX_O43318
    UniProt: O43318

  • Chr Location
    6q15; chr6:90513573-90587301 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Map3k7 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    116 phenotypes from 11 alleles in 13 genetic backgrounds
    32 phenotypes from multigenic genotypes
    2 images
    95 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality during organogenesis and may have impaired vascular remodeling, edema, or an open, wavy neural tube. Mice with conditional deletion in immune cells show impaired cell development and activation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028284 Ensembl Gene Model | MGI Sequence Detail 59371 C57BL/6J ±  kb
    transcript ENSMUST00000037607 Ensembl | MGI Sequence Detail 5773 Not Applicable  
    polypeptide ENSMUSP00000040307 Ensembl | MGI Sequence Detail 606 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000003158 mitogen-activated protein kinase kinase kinase 7
    • EC
    • InterPro Domains
      IPR017421 Mitogen-activated protein (MAP) kinase kinase kinase 7
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 18
      Primer pair 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1203726, MGI:2135559
    References
    more
    • Summaries
      All 217
      Developmental Gene Expression 26
      Diseases 1
      Gene Ontology 25
      Phenotypes 95
    • Earliest
      J:47270 Yamaguchi K, et al., Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction. Science. 1995 Dec 22;270(5244):2008-11
    • Latest
      J:264702 Hernandez C, et al., HMGB1 links chronic liver injury to progenitor responses and hepatocarcinogenesis. J Clin Invest. 2018 Jun 1;128(6):2436-2451

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory