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Map3k7 Gene Detail
Summary
  • Symbol
    Map3k7
  • Name
    mitogen-activated protein kinase kinase kinase 7
  • Synonyms
    Tak1, TAK1, TGF-beta activated kinase 1, transforming growth factor beta-activated kinase 1, transforming growth factor-beta-activated kinase 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346877
    NCBI Gene: 26409
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:31964097-32023467 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 13.91 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1491 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346877
 protein coding gene Chr4:31963659-32023470 (+)
129S1/SvImJ ENSMUSG00200012463
 protein coding gene Chr4:28670331-28728507 (+)
A/J ENSMUSG00195000171
 protein coding gene Chr4:29189576-29247753 (+)
AKR/J ENSMUSG00220014509
 protein coding gene Chr4:28981913-29040087 (+)
BALB/cJ ENSMUSG00180000146
 protein coding gene Chr4:28692732-28750906 (+)
C3H/HeJ ENSMUSG00175002297
 protein coding gene Chr4:29154654-29212827 (+)
C57BL/6NJ ENSMUSG00215000746
 protein coding gene Chr4:28762609-28821986 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025861
 protein coding gene Chr4:26421995-26478312 (+)
CAST/EiJ ENSTCUG00005000312
 protein coding gene Chr4:28633163-28690176 (+)
CBA/J ENSMUSG00210004266
 protein coding gene Chr4:28879355-28937514 (+)
DBA/2J ENSMUSG00185000251
 protein coding gene Chr4:28951755-29009930 (+)
FVB/NJ ENSMUSG00205000418
 protein coding gene Chr4:28536880-28595062 (+)
JF1/MsJ ENSUMUG00000001783
 protein coding gene Chr4:28983662-29043032 (+)
LP/J ENSMUSG00230000856
 protein coding gene Chr4:32240624-32299808 (+)
NOD/ShiLtJ ENSMUSG00190000198
 protein coding gene Chr4:28876142-28934318 (+)
NZO/HlLtJ ENSMUSG00225008363
 protein coding gene Chr4:36190718-36249900 (+)
PWK/PhJ ENSLUMG00010007402
 protein coding gene Chr4:28439434-28498909 (+)
SPRET/EiJ ENSMSPG00010002426
 protein coding gene Chr4:29265333-29323974 (+)
WSB/EiJ ENSIUOG00005004774
 protein coding gene Chr4:28680175-28738352 (+)



Homology
more
  • Human Ortholog
    MAP3K7, mitogen-activated protein kinase kinase kinase 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAP3K7, mitogen-activated protein kinase kinase kinase 7
  • Synonyms
    CSCF, FMD2, MEKK7, TAK1, TGF1a
  • Links
    NCBI Gene ID: 6885
    UniProt: O43318

  • Chr Location
    6q15; chr6:90513573-90587093 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Map3k7 mouse models; 3 with human MAP3K7 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    132 phenotypes from 11 alleles in 13 genetic backgrounds
    29 phenotypes from multigenic genotypes
    2 images
    149 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality during organogenesis and may have impaired vascular remodeling, edema, or an open, wavy neural tube. Conditional immune-cell-specific homozygous knockout leads to enlarged spleen and lymph nodes and affects immune cell cytokine production, development and activation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    187
  • GO References
    35
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    844
  • Tissues
    146
  • cDNA Data
    18
  • Literature Summary
    36
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028284 Ensembl Gene Model | MGI Sequence Detail 59371 C57BL/6J ±  kb
    transcript ENSMUST00000037607 Ensembl | MGI Sequence Detail 5773 Not Applicable  
    polypeptide ENSMUSP00000040307 Ensembl | MGI Sequence Detail 606 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000003158 mitogen-activated protein kinase kinase kinase 7
      (term hierarchy)
    • EC
      2.7.11.1, 2.7.11.25
    • InterPro Domains
      IPR060742 MAP3K7-like, C-terminal coiled coil
      IPR049637 Mitogen-activated protein kinase kinase kinase 7
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
    • GlyGen
      Q62073 7 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (4 sites)
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 18
      Primer pair 7
      Antibodies 8

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1203726, MGI:2135559
    References
    more
    • Summaries
      All 327
      Developmental Gene Expression 36
      Diseases 2
      Gene Ontology 35
      Phenotypes 149
    • Earliest
      J:47270 Yamaguchi K, et al., Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction. Science. 1995 Dec 22;270(5244):2008-11
    • Latest
      J:390094 Lopez-Perez W, et al., TAK1 inhibition activates pore-forming proteins to block intracellular bacterial growth through modulating mitochondria. Cell Death Dis. 2025 Jun 18;16(1):456
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory