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Map3k7 Gene Detail
Summary
  • Symbol
    Map3k7
  • Name
    mitogen-activated protein kinase kinase kinase 7
  • Synonyms
    Tak1, TAK1, TGF-beta activated kinase 1, transforming growth factor beta-activated kinase 1, transforming growth factor-beta-activated kinase 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346877
    NCBI Gene: 26409
Location & Maps
more
  • Sequence Map
    Chr4:31964097-32023467 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      59371 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 13.91 cM
  • Mapping Data
    4 experiments
Homology
less
Human Diseases
more
  • Diseases
    1 with Map3k7 mouse models

Human Disease Mouse Models
       Wolff-Parkinson-White Syndrome   OMIM: 194200 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    116 phenotypes from 11 alleles in 13 genetic backgrounds
    17 phenotypes from multigenic genotypes
    2 images
    81 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    68
  • Chemically and radiation induced
    1
  • Gene trapped
    55
  • Targeted
    11
  • Transgenic
    1
  • Genomic Mutations
    1 involving Map3k7
  • Incidental Mutations
Homozygous null mice display embryonic lethality during organogenesis and may have impaired vascular remodeling, edema, or an open, wavy neural tube. Mice with conditional deletion in immune cells show impaired cell development and activation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004905 VEGA Gene Model | MGI Sequence Detail 59371 C57BL/6J ±  kb
transcript OTTMUST00000010919 VEGA | MGI Sequence Detail 5773 Not Applicable  
polypeptide OTTMUSP00000005099 VEGA | MGI Sequence Detail 606 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    648 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000003158 mitogen-activated protein kinase kinase kinase 7
  • EC
  • InterPro Domains
    IPR017421 Mitogen-activated protein (MAP) kinase kinase kinase 7
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR008271 Serine/threonine-protein kinase, active site
    IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
Molecular
Reagents
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  • All nucleic 19
    cDNA 17
    Primer pair 2

    Microarray probesets 8
Other
Accession IDs
less
MGI:1203726, MGI:2135559
References
more
  • Summaries
    All 160
    Developmental Gene Expression 22
    Diseases 1
    Gene Ontology 19
    Phenotypes 81
  • Earliest
    J:47270 Yamaguchi K, et al., Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction. Science. 1995 Dec 22;270(5244):2008-11
  • Latest
    J:230793 Morioka S, et al., TAK1 regulates hepatic lipid homeostasis through SREBP. Oncogene. 2016 Mar 14;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory