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Map3k7
Gene Detail
 Symbol
Name
ID
Map3k7
mitogen-activated protein kinase kinase kinase 7
MGI:1346877
Synonyms Tak1, TAK1, TGF-beta activated kinase 1, transforming growth factor beta-activated kinase 1, transforming growth factor-beta-activated kinase 1
Feature Type protein coding gene
Genetic Map
Chromosome 4
13.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:31964097-32023467 bp, + strand
From VEGA annotation of GRCm38

  59371 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37743  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: mitogen-activated protein kinase kinase kinase 7
Gene Tree: Map3k7

Human
homologs
Human Homolog MAP3K7, mitogen-activated protein kinase kinase kinase 7
NCBI Gene ID 6885
neXtProt AC  NX_O43318
Human Synonyms  MEKK7, TAK1, TGF1a
Human Chr (Location)  6q15; chr6:90513573-90587301 (-)  GRCh38
Alleles
and
phenotypes
All alleles(64) : Targeted(9) Gene trapped(55)
 
Homozygous null mice display embryonic lethality during organogenesis and may have impaired vascular remodeling, edema, or an open, wavy neural tube. Mice with conditional deletion in immune cells show impaired cell development and activation.
 
Gene Ontology
(GO)
classifications
All GO classifications: (65 annotations)
Process activation of MAPK activity, activation of MAPKK activity, ...
Component Ada2/Gcn5/Ada3 transcription activator complex, cytoplasm, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (128)    Tissues (101)    Images (23)
Theiler Stages: 14, 17, 18, 19, 20, 21, 22, 23, 26, 28
Assay TypeResults
Immunohistochemistry 46
RNA in situ 71
RT-PCR 11
cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(19) cDNA(17) Primer pair(2)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000004905 (Evidence)
Ensembl Gene ModelENSMUSG00000028284 (Evidence)
Entrez Gene26409 (Evidence)
DFCITC1577998, TC1591499, TC1629076, TC1670702, TC1731711
DoTSDT.40153384, DT.531819, DT.97411511, DT.99606230
NIA Mouse Gene IndexU042512
EC2.7.11.25
Consensus CDS ProjectCCDS18014.1, CCDS51133.1
International Mouse Knockout Project StatusMap3k7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004905 VEGA Gene Model | MGI Sequence Detail 59371 C57BL/6J ±  kb
transcript OTTMUST00000010919 VEGA | MGI Sequence Detail 5773 Not Applicable 
polypeptide OTTMUSP00000005099 VEGA | MGI Sequence Detail 606 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(7) UniProt(6)
Polymorphisms SNPs within 2kb(667 from dbSNP Build 137)    SNPs within 2kb including multiple locations(669)
Protein-related
information
ResourceIDDescription
InterPro IPR017421 Mitogen-activated protein (MAP) kinase kinase kinase 7
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
Protein Ontology PR:000003158 mitogen-activated protein kinase kinase kinase 7
References (Earliest) J:47270 Yamaguchi K, et al., Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction. Science. 1995 Dec 22;270(5244):2008-11
(Latest) J:206842 Niu J, et al., USP10 inhibits genotoxic NF-kappaB activation by MCPIP1-facilitated deubiquitination of NEMO. EMBO J. 2013 Dec 11;32(24):3206-19
All references(133)
Other
accession IDs
MGI:1203726, MGI:2135559

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory