Map3k7
Gene Detail

Symbol Name ID

Map3k7 mitogen-activated protein kinase kinase kinase 7 MGI:1346877

Synonyms

Tak1, TAK1, TGF-beta activated kinase 1, transforming growth factor beta-activated kinase 1, transforming growth factor-beta-activated kinase 1

Feature Type

protein coding gene

Genetic Map

Chromosome 4

13.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr4:31964097-32023467 bp, + strand From VEGA annotation of GRCm38   59371 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37743  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: mitogen-activated protein kinase kinase kinase 7
Gene Tree: Map3k7

Human homologs

Human Homolog		MAP3K7, mitogen-activated protein kinase kinase kinase 7
NCBI Gene ID		6885
neXtProt AC		NX_O43318
Human Synonyms		MEKK7, TAK1, TGF1a
Human Chr (Location)		6q15; chr6:91223292-91297020 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(62) : Targeted(7) Gene trapped(55)
 

Homozygous null mice display embryonic lethality during organogenesis and may have impaired vascular remodeling, edema, or an open, wavy neural tube. Mice with conditional deletion in immune cells show impaired cell development and activation.

 

Gene Ontology (GO) classifications

All GO classifications: (55 annotations)

Process	activation of MAPK activity, activation of MAPKK activity, ...
Component	Ada2/Gcn5/Ada3 transcription activator complex, cytoplasm, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (14 records)
Data Summary: Results (81)    Tissues (64)    Images (20)
Theiler Stages: 14, 17, 18, 19, 20, 21, 22, 23

Assay Type	Results
Immunohistochemistry	46
RNA in situ	24
RT-PCR	11

cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(19) cDNA(17) Primer pair(2)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000004905 (Evidence)
Ensembl Gene Model	ENSMUSG00000028284 (Evidence)
Entrez Gene	26409 (Evidence)
DFCI	TC1577998, TC1591499, TC1629076, TC1670702, TC1731711
DoTS	DT.40153384, DT.531819, DT.97411511, DT.99606230
NIA Mouse Gene Index	U042512
EC	2.7.11.25
Consensus CDS Project	CCDS18014.1, CCDS51133.1
International Mouse Knockout Project Status	Map3k7

Sequences

Length	Strain/Species
genomic	OTTMUSG00000004905	VEGA Gene Model | MGI Sequence Detail	59371	C57BL/6J
transcript	OTTMUST00000010919	VEGA | MGI Sequence Detail	5773	Not Applicable
polypeptide	OTTMUSP00000005099	VEGA | MGI Sequence Detail	606	Not Applicable

All sequences(68) RefSeq(4) UniProt(6)

Polymorphisms

SNPs(409 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017421	Mitogen-activated protein (MAP) kinase kinase kinase 7
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
Protein Ontology	PR:000003158	mitogen-activated protein kinase kinase kinase 7
Protein Ontology	PR:000027099	mitogen-activated protein kinase kinase kinase 7 (mouse)

References

(Earliest) J:47270 Yamaguchi K, et al., Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction. Science. 1995 Dec 22;270(5244):2008-11
(Latest) J:195312 Mancino A, et al., I kappa B kinase alpha (IKKalpha) activity is required for functional maturation of dendritic cells and acquired immunity to infection. EMBO J. 2013 Mar 20;32(6):816-28
All references(119)

Other accession IDs

MGI:1203726, MGI:2135559