Tg(CAG-Map3k7*K63W)1232Mds
Transgene Detail

Summary

• Symbol: Tg(CAG-Map3k7*K63W)1232Mds
• Name: transgene insertion 1232, Michael D Schneider
• MGI ID: MGI:4461396
• Synonyms: CAG-CAT^lox-TAK1^K63W, stop-dnTAK, Tg(ACTB-Map3k7*K63W)1232Mds
• Transgene: Tg(CAG-Map3k7*K63W)1232Mds Location: unknown
• Alliance: Tg(CAG-Map3k7*K63W)1232Mds page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-Map3k7*K63W)1232Mds expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Map3k7 (MGI:1346877)	Transgene codes for a protein with a lysine to tryptophan mutation.

• Mutation details: This transgene consists of the chicken beta-actin promoter followed by a loxP flanked stop, a kinase-inactive Map3k7 with a K63W mutation, and a polyadenylation signal. Cre mediated recombination removes the stop and allows expression of the kinase-inactive Map3k7 gene. Map3k7 expression is increased about 4 fold and this is the highest expressing line. (J:117108)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:117108 Xie M, et al., A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17378-83
• All: 1 reference(s)