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Map3k3 Gene Detail
Summary
  • Symbol
    Map3k3
  • Name
    mitogen-activated protein kinase kinase kinase 3
  • Synonyms
    MAPKKK3, Mekk3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346874
    NCBI Gene: 26406
  • Gene Overview
    MyGene.info: MAP3K3
Location & Maps
more
  • Sequence Map
    Chr11:106084613-106155446 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      70834 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 68.89 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    MAP3K3, mitogen-activated protein kinase kinase kinase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAP3K3, mitogen-activated protein kinase kinase kinase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MAPKKK3, MEKK3
  • Links
    NCBI Gene ID: 4215
    neXtProt AC: NX_Q99759

  • Chr Location
    17q23.3; chr17:63622209-63696310 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 3 alleles in 3 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene die as embryos before E11.5. vascular remodeling does not take place normally.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003076 VEGA Gene Model | MGI Sequence Detail 70834 C57BL/6J ±  kb
transcript OTTMUST00000006328 VEGA | MGI Sequence Detail 3450 Not Applicable  
polypeptide OTTMUSP00000002980 VEGA | MGI Sequence Detail 626 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    174 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 154
    cDNA 152
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-39592, MGI:109593, MGI:2144565
References
more
  • Summaries
    All 49
    Developmental Gene Expression 6
    Gene Ontology 10
    Phenotypes 14
  • Earliest
    J:31860 Blank JL, et al., Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase. J Biol Chem. 1996 Mar 8;271(10):5361-8
  • Latest
    J:232707 Zhou Z, et al., Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling. Nature. 2016 Apr 7;532(7597):122-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory