Map3k3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Map3k3
mitogen-activated protein kinase kinase kinase 3
MGI:1346874

25 phenotypes from 5 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Map3k3^tm1.1Mlkn/Map3k3^tm1.2Mlkn Nfatc1^tm1.1(cre)Bz/Nfatc1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac	embryonic lethality during organogenesis	J:238897
	thin myocardium	J:238897
Map3k3^tm1Bisu/Map3k3^tm1Bisu Not Specified	abnormal heart atrium morphology	J:60748
	abnormal heart development	J:60748
	abnormal heart morphology	J:60748
	abnormal myocardium layer morphology	J:60748
	abnormal placental labyrinth vasculature morphology	J:60748
	abnormal vascular development	J:60748
	abnormal vitelline vascular remodeling	J:60748
	decreased angiogenesis	J:60748
	embryonic lethality during organogenesis, complete penetrance	J:60748
	microcephaly	J:60748
	trabecula carnea hypoplasia	J:60748
Map3k3^tm1Bisu/Map3k3^tm2Bisu Tg(Lck-cre)548Jxm/0 involves: C57BL/6 * CBA	abnormal T cell physiology	J:145923
	abnormal T cell proliferation	J:145923
	decreased CD4-positive, alpha-beta T cell number	J:145923
	decreased CD8-positive, alpha-beta T cell number	J:145923
	spleen hypoplasia	J:145923
Map3k3^tm1Kuro/Map3k3^tm1Kuro Tg(Lck-cre)1Jtak/0 involves: C57BL/6	decreased CD4-positive, alpha-beta T cell number	J:147103
	decreased CD8-positive, alpha-beta T cell number	J:147103
	decreased double-positive T cell number	J:147103
	decreased interferon-gamma secretion	J:147103
	decreased interleukin-2 secretion	J:147103
	decreased single-positive T cell number	J:147103
	decreased T cell proliferation	J:147103
	decreased thymocyte number	J:147103
	increased double-negative T cell number	J:147103

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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