Gene Expression Literature Summary

• Symbol: Map3k3
• Name: mitogen-activated protein kinase kinase kinase 3
• ID: MGI:1346874

7 matching records from 7 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2	E2.5	E3	E4	E8	E9	E9.5	E10.5	E12.5	E13.5	E14.5	E17.5	P
Immunohistochemistry (section)									1	1	1	1
Immunohistochemistry (whole mount)	1	1	1	1	1	1
Western blot									1		1				1
RT-PCR	1	1	1	1	1	1	1	2	1	1			1	1	1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Map3k3  mitogen-activated protein kinase kinase kinase 3   (Synonyms: MAPKKK3, Mekk3)
Results	Reference
1	J:123909 Breitwieser W, Lyons S, Flenniken AM, Ashton G, Bruder G, Willington M, Lacaud G, Kouskoff V, Jones N, Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells. Genes Dev. 2007 Aug 15;21(16):2069-82
1	J:224922 Fisher OS, Deng H, Liu D, Zhang Y, Wei R, Deng Y, Zhang F, Louvi A, Turk BE, Boggon TJ, Su B, Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex. Nat Commun. 2015;6:7937
13*	J:119912 Fong B, Watson PH, Watson AJ, Mouse preimplantation embryo responses to culture medium osmolarity include increased expression of CCM2 and p38 MAPK activation. BMC Dev Biol. 2007;7:2
1	J:147287 Retting KN, Song B, Yoon BS, Lyons KM, BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation. Development. 2009 Apr;136(7):1093-104
9*	J:155266 Stevens MV, Broka DM, Parker P, Rogowitz E, Vaillancourt RR, Camenisch TD, MEKK3 initiates transforming growth factor beta 2-dependent epithelial-to-mesenchymal transition during endocardial cushion morphogenesis. Circ Res. 2008 Dec 5;103(12):1430-40
1	J:339061 Tsitsikov EN, Phan KP, Liu Y, Tsytsykova AV, Kinter M, Selland L, Garman L, Griffin C, Dunn IF, TRAF7 is an essential regulator of blood vessel integrity during mouse embryonic and neonatal development. iScience. 2023 Aug 18;26(8):107474
1*	J:60748 Yang J, Boerm M, McCarty M, Bucana C, Fidler IJ, Zhuang Y, Su B, Mekk3 is essential for early embryonic cardiovascular development. Nat Genet. 2000 Mar;24(3):309-13