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Mapk14 Gene Detail
Summary
  • Symbol
    Mapk14
  • Name
    mitogen-activated protein kinase 14
  • Synonyms
    Crk1, Csbp1, CSBP2, Mxi2, p38, p38a, p38alpha, p38 alpha, p38-alpha, p38MAPK, p38 MAPK, p38 MAP Kinase, p38 MAP kinase alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346865
    NCBI Gene: 26416
  • Gene Overview
    MyGene.info: MAPK14
Location & Maps
more
  • Sequence Map
    Chr17:28691342-28748404 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      57063 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 14.85 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    MAPK14, mitogen-activated protein kinase 14
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAPK14, mitogen-activated protein kinase 14
    Orthology source: HomoloGene
  • Synonyms
    CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, p38, p38ALPHA, PRKM14, PRKM15, RK, SAPK2A
  • Links
    NCBI Gene ID: 1432
    neXtProt AC: NX_Q16539

  • Chr Location
    6p21.3-p21.2; chr6:36027635-36111236 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    88 phenotypes from 14 alleles in 17 genetic backgrounds
    32 phenotypes from multigenic genotypes
    6 images
    92 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for various null mutations are embryonic to perinatal lethal showing multiple organ system defects. Mice homozygous for a knock-out mutation exhibit abnormal myoblast differentiation and delayed myofiber growth and maturation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020086 VEGA Gene Model | MGI Sequence Detail 57063 C57BL/6J ±  kb
transcript OTTMUST00000047771 VEGA | MGI Sequence Detail 3547 Not Applicable  
polypeptide OTTMUSP00000021705 VEGA | MGI Sequence Detail 360 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    286 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 175
    cDNA 172
    Primer pair 2
    Other 1

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-2145, MGI:1338028, MGI:88502
References
more
  • Summaries
    All 372
    Developmental Gene Expression 106
    Gene Ontology 41
    Phenotypes 92
  • Earliest
    J:4073 Ershler M, et al., Novel CDC2-related protein kinases produced in murine hematopoietic stem cells. Gene. 1993 Feb 28;124(2):305-6
  • Latest
    J:229763 Lee SM, et al., Myristoylated alanine-rich C kinase substrate (MARCKS) regulates the expression of proinflammatory cytokines in macrophages through activation of p38/JNK MAPK and NF-kappaB. Cell Immunol. 2015 Aug;296(2):115-21

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory