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Mapk14 Gene Detail
Summary
  • Symbol
    Mapk14
  • Name
    mitogen-activated protein kinase 14
  • Synonyms
    Crk1, Csbp1, CSBP2, Mxi2, p38, p38a, p38alpha, p38 alpha, p38-alpha, p38MAPK, p38 MAPK, p38 MAP Kinase, p38 MAP kinase alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346865
    NCBI Gene: 26416
  • Gene Overview
    MyGene.info: MAPK14
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:28691342-28748404 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 14.85 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    286 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346865
protein coding gene Chr17:28691342-28748405 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023448
protein coding gene Chr17:28136812-28199737 (+)
A/J MGP_AJ_G0023406
protein coding gene Chr17:27193056-27250504 (+)
AKR/J MGP_AKRJ_G0023371
protein coding gene Chr17:27401683-27459636 (+)
BALB/cJ MGP_BALBcJ_G0023411
protein coding gene Chr17:27462694-27521053 (+)
C3H/HeJ MGP_C3HHeJ_G0023172
protein coding gene Chr17:27799638-27857111 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023853
protein coding gene Chr17:29267687-29328560 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021328
protein coding gene Chr17:24549043-24605388 (+)
CAST/EiJ MGP_CASTEiJ_G0022673
protein coding gene Chr17:27770115-27828510 (+)
CBA/J MGP_CBAJ_G0023146
protein coding gene Chr17:30343563-30404097 (+)
DBA/2J MGP_DBA2J_G0023277
protein coding gene Chr17:26741147-26798857 (+)
FVB/NJ MGP_FVBNJ_G0023247
protein coding gene Chr17:26570306-26627346 (+)
LP/J MGP_LPJ_G0023355
protein coding gene Chr17:28387013-28449274 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023265
protein coding gene Chr17:29737152-29795886 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023895
protein coding gene Chr17:27844935-27902402 (+)
PWK/PhJ MGP_PWKPhJ_G0022423
protein coding gene Chr17:25565917-25623787 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022241
protein coding gene Chr17:25831805-25897623 (+)
WSB/EiJ MGP_WSBEiJ_G0022735
protein coding gene Chr17:27828591-27886715 (+)



Homology
more
  • Human Ortholog
    MAPK14, mitogen-activated protein kinase 14
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAPK14, mitogen-activated protein kinase 14
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, p38, p38ALPHA, PRKM14, PRKM15, RK, SAPK2A
  • Links
    NCBI Gene ID: 1432
    neXtProt AC: NX_Q16539
    UniProt: Q16539

  • Chr Location
    6p21.31; chr6:36027635-36122964 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    90 phenotypes from 14 alleles in 18 genetic backgrounds
    32 phenotypes from multigenic genotypes
    6 images
    115 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for various null mutations are embryonic to perinatal lethal showing multiple organ system defects. Mice homozygous for a knock-out mutation exhibit abnormal myoblast differentiation and delayed myofiber growth and maturation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000053436 Ensembl Gene Model | MGI Sequence Detail 57063 C57BL/6J ±  kb
    transcript ENSMUST00000004990 Ensembl | MGI Sequence Detail 3562 Not Applicable  
    polypeptide ENSMUSP00000004990 Ensembl | MGI Sequence Detail 360 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 177
      cDNA 174
      Primer pair 2
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-2145, MGI:1338028, MGI:88502
    References
    more
    • Summaries
      All 593
      Developmental Gene Expression 128
      Gene Ontology 49
      Phenotypes 115
    • Earliest
      J:4073 Ershler M, et al., Novel CDC2-related protein kinases produced in murine hematopoietic stem cells. Gene. 1993 Feb 28;124(2):305-6
    • Latest
      J:266667 Bosquet A, et al., FABP4 inhibitor BMS309403 decreases saturated-fatty-acid-induced endoplasmic reticulum stress-associated inflammation in skeletal muscle by reducing p38 MAPK activation. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Jun;1863(6):604-613

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory