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Mapk14
Gene Detail
 Symbol
Name
ID
Mapk14
mitogen-activated protein kinase 14
MGI:1346865
Synonyms Crk1, Csbp1, CSBP2, Mxi2, p38, p38a, p38alpha, p38 alpha, p38-alpha, p38MAPK, p38 MAPK, p38 MAP Kinase, p38 MAP kinase alpha
Feature Type protein coding gene
Genetic Map
Chromosome 17
14.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr17:28691342-28748404 bp, + strand
From VEGA annotation of GRCm38

  57063 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31777  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Mapk14

Human
homologs
Human Homolog MAPK14, mitogen-activated protein kinase 14
NCBI Gene ID 1432
neXtProt AC  NX_Q16539
Human Synonyms  CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, p38, p38ALPHA, PRKM14, PRKM15, RK, SAPK2A
Human Chr (Location)  6p21.3-p21.2; chr6:36027677-36111236 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Gene trapped(9) Targeted(16)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for various null mutations are embryonic to perinatal lethal showing multiple organ system defects. Mice homozygous for a knock-out mutation exhibit abnormal myoblast differentiation and delayed myofiber growth and maturation.
 
Phenotype Images(6)
Interactions
Mapk14 interacts with 267 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (72 annotations)
Process angiogenesis, apoptotic process, ...
Component cell, cytoplasm, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (83 records)
Data Summary: Results (68)    Tissues (32)    Images (16)
Theiler Stages: 4, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 3
RNA in situ 27
Western blot 31
RT-PCR 7
cDNA source data(172)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(174) cDNA(172) Primer pair(1) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000020086 (Evidence)
Ensembl Gene ModelENSMUSG00000053436 (Evidence)
Entrez Gene26416 (Evidence)
UniGene311337
DFCITC1574215, TC1587794, TC1624382, TC1727945, TC1777454
DoTSDT.101259998, DT.101368889, DT.110556610, DT.110556628, DT.495086, DT.94167104
NIA Mouse Gene IndexU017752
EC2.7.11.24
PDB1LEW, 1LEZ, 1YWR, 2EWA, 2GHL, 2GHM, 2GTM, 2GTN, 2OZA, 2PUU, 3P4K, 3P5K, 3P7A, 3P7B, 3P7C, 4LOO, 4LOP, 4LOQ, 1P38, 1YW2, 3P78, 3P79, 3PY3, 3TG1, 4KA3
Consensus CDS ProjectCCDS28583.1, CCDS50048.1, CCDS50049.1
International Mouse Knockout Project StatusMapk14
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020086 VEGA Gene Model | MGI Sequence Detail 57063 C57BL/6J ±  kb
transcript OTTMUST00000047771 VEGA | MGI Sequence Detail 3547 Not Applicable 
polypeptide OTTMUSP00000021705 VEGA | MGI Sequence Detail 360 Not Applicable 

For the selected sequences
All sequences(84) RefSeq(12) UniProt(4)
Polymorphisms SNPs within 2kb(287 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003527 Mitogen-activated protein (MAP) kinase, conserved site
InterPro IPR008352 Mitogen-activated protein (MAP) kinase, p38
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
Protein Ontology PR:000003107 mitogen-activated protein kinase 14
References (Earliest) J:4073 Ershler M, et al., Novel CDC2-related protein kinases produced in murine hematopoietic stem cells. Gene. 1993 Feb 28;124(2):305-6
(Latest) J:210810 Gupta J, et al., Dual function of p38alpha MAPK in colon cancer: suppression of colitis-associated tumor initiation but requirement for cancer cell survival. Cancer Cell. 2014 Apr 14;25(4):484-500
All references(333)
Other
accession IDs
MGD-MRK-2145, MGI:1338028, MGI:88502

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory