Mapk14
Gene Detail

Symbol Name ID

Mapk14 mitogen-activated protein kinase 14 MGI:1346865

Synonyms

Crk1, Csbp1, CSBP2, Mxi2, p38, p38a, p38alpha, p38 alpha, p38-alpha, p38MAPK, p38 MAPK, p38 MAP Kinase, p38 MAP kinase alpha

Feature Type

protein coding gene

Genetic Map

Chromosome 17

14.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr17:28691342-28748404 bp, + strand From VEGA annotation of GRCm38   57063 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31777  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Mapk14

Human homologs

Human Homolog		MAPK14, mitogen-activated protein kinase 14
NCBI Gene ID		1432
neXtProt AC		NX_Q16539
Human Synonyms		CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, p38, p38ALPHA, PRKM14, PRKM15, RK, SAPK2A
Human Chr (Location)		6p21.3-p21.2; chr6:35995454-36079013 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(24) : Targeted(15) Gene trapped(9)
 

Mice homozygous for various null mutations are embryonic to perinatal lethal showing multiple organ system defects.

 
Phenotype Images(6)

Gene Ontology (GO) classifications

All GO classifications: (63 annotations)

Process	angiogenesis, apoptotic process, ...
Component	cell, cytoplasm, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (72 records)
Data Summary: Results (64)    Tissues (31)    Images (14)
Theiler Stages: 4, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	3
RNA in situ	27
Western blot	27
RT-PCR	7

cDNA source data(175)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(177) cDNA(175) Primer pair(1) Other(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000020086 (Evidence)
Ensembl Gene Model	ENSMUSG00000053436 (Evidence)
Entrez Gene	26416 (Evidence)
UniGene	311337
DFCI	TC1574215, TC1587794, TC1624382, TC1727945, TC1777454
DoTS	DT.101259998, DT.101368889, DT.110556610, DT.110556628, DT.495086, DT.94167104
NIA Mouse Gene Index	U017752
EC	2.7.11.24
PDB	1LEW, 1LEZ, 1YWR, 2EWA, 2GHL, 2GHM, 2GTM, 2GTN, 2OZA, 2PUU, 3P4K, 3P5K, 3P7A, 3P7B, 3P7C, 1P38, 1YW2, 3P78, 3P79, 3PY3, 3TG1
Consensus CDS Project	CCDS28583.1, CCDS50048.1, CCDS50049.1
International Mouse Knockout Project Status	Mapk14

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020086	VEGA Gene Model | MGI Sequence Detail	57063	C57BL/6J
transcript	OTTMUST00000047771	VEGA | MGI Sequence Detail	3547	Not Applicable
polypeptide	OTTMUSP00000021705	VEGA | MGI Sequence Detail	360	Not Applicable

All sequences(80) RefSeq(8) UniProt(4)

Polymorphisms

SNPs(254 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003527	Mitogen-activated protein (MAP) kinase, conserved site
InterPro	IPR008352	Mitogen-activated protein (MAP) kinase, p38
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
Protein Ontology	PR:000003107	mitogen-activated protein kinase 14

References

(Earliest) J:4073 Ershler M, et al., Novel CDC2-related protein kinases produced in murine hematopoietic stem cells. Gene. 1993 Feb 28;124(2):305-6
(Latest) J:194358 Sakurai T, et al., p38alpha inhibits liver fibrogenesis and consequent hepatocarcinogenesis by curtailing accumulation of reactive oxygen species. Cancer Res. 2013 Jan 1;73(1):215-24
All references(296)

Other accession IDs

MGD-MRK-2145, MGI:1338028, MGI:88502