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Mapk14
Gene Detail
Symbol

Name
ID
Mapk14
mitogen-activated protein kinase 14
MGI:1346865
Synonyms
Crk1, Csbp1, CSBP2, Mxi2, p38, p38a, p38alpha, p38 alpha, p38-alpha, p38MAPK, p38 MAPK, p38 MAP Kinase, p38 MAP kinase alpha
Feature Type
protein coding gene
Genetic Map
Chromosome 17
14.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr17:28691342-28748404 bp, + strand
From VEGA annotation of GRCm38

  57063 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31777  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MAPK14
Protein SuperFamily: kinase-related transforming protein
Gene Tree: Mapk14

Human
homologs
MAPK14, mitogen-activated protein kinase 14
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1432
neXtProt AC: NX_Q16539

Human Synonyms: CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, p38, p38ALPHA, PRKM14, PRKM15, RK, SAPK2A

Human Chr (Location): 6p21.3-p21.2; chr6:36027635-36111236 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Gene trapped(9) Targeted(16) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for various null mutations are embryonic to perinatal lethal showing multiple organ system defects. Mice homozygous for a knock-out mutation exhibit abnormal myoblast differentiation and delayed myofiber growth and maturation.
 
Phenotype Images(6)
Interactions
Mapk14 interacts with 266 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (85 annotations)
Process angiogenesis, apoptotic process, ...
Component cell, cytoplasm, ...
Function ATP binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (98 records)
Data Summary: Results (114)    Tissues (45)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 11
RNA in situ 27
Western blot 63
RT-PCR 13
cDNA source data(172)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mapk14 ; ZFIN mapk14a, mapk14b    NEW 
Molecular
reagents
All nucleic(175) cDNA(172) Primer pair(2) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000020086 (Evidence)
Ensembl Gene Model ENSMUSG00000053436 (Evidence)
Entrez Gene 26416 (Evidence)
UniGene 311337
DFCI TC1574215, TC1587794, TC1624382, TC1727945, TC1777454
DoTS DT.101259998, DT.101368889, DT.110556610, DT.110556628, DT.495086, DT.94167104
NIA Mouse Gene Index U017752
EC 2.7.11.24
PDB 1LEW, 1LEZ, 1P38, 1YW2, 1YWR, 2EWA, 2GHL, 2GHM, 2GTM, 2GTN, 2OZA, 2PUU, 3P4K, 3P5K, 3P78, 3P79, 3P7A, 3P7B, 3P7C, 3PY3, 3TG1, 4KA3, 4LOO, 4LOP, 4LOQ
Consensus CDS Project CCDS28583.1, CCDS50048.1, CCDS50049.1
International Mouse Phenotyping Consortium Status Mapk14
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020086 VEGA Gene Model | MGI Sequence Detail 57063 C57BL/6J ±  kb
transcript OTTMUST00000047771 VEGA | MGI Sequence Detail 3547 Not Applicable 
polypeptide OTTMUSP00000021705 VEGA | MGI Sequence Detail 360 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(8) UniProt(4)
Polymorphisms
SNPs within 2kb(287 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003527 Mitogen-activated protein (MAP) kinase, conserved site
InterPro IPR008352 Mitogen-activated protein (MAP) kinase, p38
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
Protein Ontology PR:000003107 mitogen-activated protein kinase 14
References
(Earliest) J:4073 Ershler M, et al., Novel CDC2-related protein kinases produced in murine hematopoietic stem cells. Gene. 1993 Feb 28;124(2):305-6
(Latest) J:221495 Tapia O, et al., Nuclear envelope protein Lem2 is required for mouse development and regulates MAP and AKT kinases. PLoS One. 2015;10(3):e0116196
All references(359)
Other
accession IDs
MGD-MRK-2145, MGI:1338028, MGI:88502

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory