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Mapk14 Gene Detail
Summary
  • Symbol
    Mapk14
  • Name
    mitogen-activated protein kinase 14
  • Synonyms
    Crk1, Csbp1, CSBP2, Mxi2, p38, p38a, p38alpha, p38 alpha, p38-alpha, p38MAPK, p38 MAPK, p38 MAP Kinase, p38 MAP kinase alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346865
    NCBI Gene: 26416
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:28910303-28967380 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 17, 14.85 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    286 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346865
protein coding gene Chr17:28910243-28967380 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023448
protein coding gene Chr17:28136812-28199737 (+)
A/J MGP_AJ_G0023406
protein coding gene Chr17:27193056-27250504 (+)
AKR/J MGP_AKRJ_G0023371
protein coding gene Chr17:27401683-27459636 (+)
BALB/cJ MGP_BALBcJ_G0023411
protein coding gene Chr17:27462694-27521053 (+)
C3H/HeJ MGP_C3HHeJ_G0023172
protein coding gene Chr17:27799638-27857111 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023853
protein coding gene Chr17:29267687-29328560 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021328
protein coding gene Chr17:24549043-24605388 (+)
CAST/EiJ MGP_CASTEiJ_G0022673
protein coding gene Chr17:27770115-27828510 (+)
CBA/J MGP_CBAJ_G0023146
protein coding gene Chr17:30343563-30404097 (+)
DBA/2J MGP_DBA2J_G0023277
protein coding gene Chr17:26741147-26798857 (+)
FVB/NJ MGP_FVBNJ_G0023247
protein coding gene Chr17:26570306-26627346 (+)
LP/J MGP_LPJ_G0023355
protein coding gene Chr17:28387013-28449274 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023265
protein coding gene Chr17:29737152-29795886 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023895
protein coding gene Chr17:27844935-27902402 (+)
PWK/PhJ MGP_PWKPhJ_G0022423
protein coding gene Chr17:25565917-25623787 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022241
protein coding gene Chr17:25831805-25897623 (+)
WSB/EiJ MGP_WSBEiJ_G0022735
protein coding gene Chr17:27828591-27886715 (+)



Homology
more
  • Human Ortholog
    MAPK14, mitogen-activated protein kinase 14
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAPK14, mitogen-activated protein kinase 14
  • Synonyms
    CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, p38, p38ALPHA, PRKM14, PRKM15, RK, SAPK2A
  • Links
    NCBI Gene ID: 1432
    neXtProt AC: NX_Q16539
    UniProt: Q16539

  • Chr Location
    6p21.31; chr6:36027782-36124214 (+)  GRCh38

Human Diseases
more
  • Diseases
    4 with human MAPK14 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    83 phenotypes from 13 alleles in 16 genetic backgrounds
    44 phenotypes from multigenic genotypes
    6 images
    169 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for various null mutations are embryonic to perinatal lethal showing multiple organ system defects. Mice homozygous for a knock-out mutation exhibit abnormal myoblast differentiation and delayed myofiber growth and maturation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000053436 Ensembl Gene Model | MGI Sequence Detail 57078 C57BL/6J ±  kb
    transcript ENSMUST00000062694 Ensembl | MGI Sequence Detail 3548 Not Applicable  
    polypeptide ENSMUSP00000061958 Ensembl | MGI Sequence Detail 360 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 177
      cDNA 174
      Primer pair 2
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-2145, MGI:1338028, MGI:88502
    References
    more
    • Summaries
      All 732
      Developmental Gene Expression 164
      Gene Ontology 51
      Phenotypes 169
    • Earliest
      J:4073 Ershler M, et al., Novel CDC2-related protein kinases produced in murine hematopoietic stem cells. Gene. 1993 Feb 28;124(2):305-6
    • Latest
      J:345213 Luo D, et al., Involvement of p38 MAPK in Leydig cell aging and age-related decline in testosterone. Front Endocrinol (Lausanne). 2023;14:1088249

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory