Esrrb
Gene Detail

Symbol Name ID

Esrrb estrogen related receptor, beta MGI:1346832

Synonyms

Err2, ERR2, ERRb, Estrrb

Feature Type

protein coding gene

Genetic Map

Chromosome 12

40.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr12:86361117-86521628 bp, + strand From VEGA annotation of GRCm38   160512 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:69108  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: ER-like_NR
Gene Tree: Esrrb

Human homologs

Human Homolog		ESRRB, estrogen-related receptor beta
NCBI Gene ID		2103
neXtProt AC		NX_O95718
Human Synonyms		DFNB35, ERR2, ERRb, ESRL2, NR3B2
Human Chr (Location)		14q24.3; chr14:76837690-76968180 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ESRRB

Alleles and phenotypes

All alleles(271) : Targeted(5) Gene trapped(266)
 

Mice homozygous for disruptions in this gene die as embryos around E9.5 or E10.5 as a result of failure of the chorion to develop and subsequent placental defects.

 

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	embryonic placenta development, in utero embryonic development, ...
Component	nucleus
Function	DNA binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (26 records)
Data Summary: Results (310)    Tissues (219)    Images (72)
Theiler Stages: 2, 3, 4, 5, 7, 8, 9, 10, 11, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	16
RNA in situ	213
Northern blot	6
RT-PCR	75

cDNA source data(32)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(42) Genomic(2) cDNA(33) Primer pair(5) Other(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000023036 (Evidence)
Ensembl Gene Model	ENSMUSG00000021255 (Evidence)
Entrez Gene	26380 (Evidence)
UniGene	235550
DFCI	TC1598975, TC1629454
DoTS	DT.101384607, DT.40181227, DT.97378576
NIA Mouse Gene Index	U014218
Consensus CDS Project	CCDS26066.2, CCDS49117.1
International Mouse Knockout Project Status	Esrrb

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023036	VEGA Gene Model | MGI Sequence Detail	160512	C57BL/6J
transcript	OTTMUST00000055512	VEGA | MGI Sequence Detail	4196	Not Applicable
polypeptide	OTTMUSP00000026587	VEGA | MGI Sequence Detail	454	Not Applicable

All sequences(53) RefSeq(4) UniProt(7)

Polymorphisms

RFLP(1) : SNPs(625 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008946	Nuclear hormone receptor, ligand-binding
InterPro	IPR000536	Nuclear hormone receptor, ligand-binding, core
InterPro	IPR024178	Oestrogen receptor-related nuclear receptor
InterPro	IPR001723	Steroid hormone receptor
InterPro	IPR013088	Zinc finger, NHR/GATA-type
InterPro	IPR001628	Zinc finger, nuclear hormone receptor-type
Protein Ontology	PR:000007209	steroid hormone receptor ERR2

References

(Earliest) J:31609 Pettersson K, et al., Expression of a novel member of estrogen response element-binding nuclear receptors is restricted to the early stages of chorion formation during mouse embryogenesis. Mech Dev. 1996 Feb;54(2):211-23
(Latest) J:193651 Martello G, et al., Esrrb is a pivotal target of the Gsk3/Tcf3 axis regulating embryonic stem cell self-renewal. Cell Stem Cell. 2012 Oct 5;11(4):491-504
All references(70)

Other accession IDs

MGD-MRK-35849, MGI:107382