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Esrrb
Gene Detail
 Symbol
Name
ID
Esrrb
estrogen related receptor, beta
MGI:1346832
Synonyms Err2, ERR2, ERRb, Estrrb
Feature Type protein coding gene
Genetic Map
Chromosome 12
40.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:86361117-86521628 bp, + strand
From VEGA annotation of GRCm38

  160512 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69108  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: ER-like_NR
Gene Tree: Esrrb

Human
homologs
Human Homolog ESRRB, estrogen-related receptor beta
NCBI Gene ID 2103
neXtProt AC  NX_O95718
Human Synonyms  DFNB35, ERR2, ERRb, ESRL2, NR3B2
Human Chr (Location)  14q24.3; chr14:76323917-76501837 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ESRRB
Mutations,
alleles, and
phenotypes
All mutations/alleles(273) : Gene trapped(266) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene die as embryos around E9.5 or E10.5 as a result of failure of the chorion to develop and subsequent placental defects.
 
Interactions
Esrrb interacts with 278 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process embryonic placenta development, in utero embryonic development, ...
Component nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (28 records)
Data Summary: Results (301)    Tissues (219)    Images (72)
Theiler Stages: 2, 3, 4, 5, 7, 8, 9, 10, 11, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
Immunohistochemistry 16
RNA in situ 213
Northern blot 6
RT-PCR 66
cDNA source data(33)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(43) Genomic(2) cDNA(34) Primer pair(5) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000023036 (Evidence)
Ensembl Gene ModelENSMUSG00000021255 (Evidence)
Entrez Gene26380 (Evidence)
UniGene235550
DFCITC1598975, TC1629454
DoTSDT.101384607, DT.40181227, DT.97378576
NIA Mouse Gene IndexU014218
Consensus CDS ProjectCCDS26066.2, CCDS49117.1
International Mouse Knockout Project StatusEsrrb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023036 VEGA Gene Model | MGI Sequence Detail 160512 C57BL/6J ±  kb
transcript OTTMUST00000055512 VEGA | MGI Sequence Detail 4196 Not Applicable 
polypeptide OTTMUSP00000026587 VEGA | MGI Sequence Detail 454 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(10) UniProt(7)
Polymorphisms RFLP(1) : SNPs within 2kb(610 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR024178 Oestrogen receptor/oestrogen-related receptor
InterPro IPR027289 Oestrogen-related receptor
InterPro IPR001723 Steroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000007209 steroid hormone receptor ERR2
References (Earliest) J:31609 Pettersson K, et al., Expression of a novel member of estrogen response element-binding nuclear receptors is restricted to the early stages of chorion formation during mouse embryogenesis. Mech Dev. 1996 Feb;54(2):211-23
(Latest) J:210467 Kang E, et al., Nuclear reprogramming by interphase cytoplasm of two-cell mouse embryos. Nature. 2014 May 1;509(7498):101-4
All references(76)
Other
accession IDs
MGD-MRK-35849, MGI:107382

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory