About   Help   FAQ
Esrrb
Gene Detail
Symbol

Name
ID
Esrrb
estrogen related receptor, beta
MGI:1346832
Synonyms
Err2, ERR2, ERRb, Estrrb
Feature Type
protein coding gene
Genetic Map
Chromosome 12
40.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:86361117-86521628 bp, + strand
From VEGA annotation of GRCm38

  160512 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69108  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: ESRRB
Protein SuperFamily: ER-like_NR
Gene Tree: Esrrb

Human
homologs
ESRRB, estrogen-related receptor beta
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2103
neXtProt AC: NX_O95718

Human Synonyms: DFNB35, ERR2, ERRb, ESRL2, NR3B2

Human Chr (Location): 14q24.3; chr14:76371299-76501839 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ESRRB

Mutations,
alleles, and
phenotypes
All mutations/alleles(273) : Gene trapped(266) Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene die as embryos around E9.5 or E10.5 as a result of failure of the chorion to develop and subsequent placental defects.
 
Interactions
Esrrb interacts with 278 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process embryonic placenta development, in utero embryonic development, ...
Component nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (34 records)
Data Summary: Results (301)    Tissues (219)    Images (72)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 16
RNA in situ 213
Northern blot 6
RT-PCR 66
cDNA source data(33)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN esrrb    NEW 
Molecular
reagents
All nucleic(43) Genomic(2) cDNA(34) Primer pair(5) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000023036 (Evidence)
Ensembl Gene Model ENSMUSG00000021255 (Evidence)
Entrez Gene 26380 (Evidence)
UniGene 235550
DFCI TC1629454, TC1598975
DoTS DT.97378576, DT.40181227, DT.101384607
NIA Mouse Gene Index U014218
Consensus CDS Project CCDS26066.2, CCDS49117.1
International Mouse Phenotyping Consortium Status Esrrb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023036 VEGA Gene Model | MGI Sequence Detail 160512 C57BL/6J ±  kb
transcript OTTMUST00000055512 VEGA | MGI Sequence Detail 4196 Not Applicable 
polypeptide OTTMUSP00000026587 VEGA | MGI Sequence Detail 454 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(10) UniProt(6)
Polymorphisms
RFLP(1) : SNPs within 2kb(610 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR024178 Oestrogen receptor/oestrogen-related receptor
InterPro IPR027289 Oestrogen-related receptor
InterPro IPR001723 Steroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000007209 steroid hormone receptor ERR2
References
(Earliest) J:31609 Pettersson K, et al., Expression of a novel member of estrogen response element-binding nuclear receptors is restricted to the early stages of chorion formation during mouse embryogenesis. Mech Dev. 1996 Feb;54(2):211-23
(Latest) J:221169 Kumar A, et al., Nodal signaling from the visceral endoderm is required to maintain Nodal gene expression in the epiblast and drive DVE/AVE migration. Dev Biol. 2015 Apr 1;400(1):1-9
All references(83)
Other
accession IDs
MGD-MRK-35849, MGI:107382

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/28/2015
MGI 5.22
The Jackson Laboratory