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Sgcg
Gene Detail
 Symbol
Name
ID
Sgcg
sarcoglycan, gamma (dystrophin-associated glycoprotein)
MGI:1346524
Synonyms 5430420E18Rik, gamma-SG
Feature Type protein coding gene
Genetic Map
Chromosome 14
32.27 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:61221059-61258490 bp, - strand
From VEGA annotation of GRCm38

  37432 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:194  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: sarcoglycan, beta/gamma/delta/zeta types
Gene Tree: Sgcg

Human
homologs
Human Homolog SGCG, sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
NCBI Gene ID 6445
neXtProt AC  NX_Q13326
Human Synonyms  A4, DAGA4, DMDA, DMDA1, LGMD2C, MAM, SCARMD2, SCG3, TYPE
Human Chr (Location)  13q12; chr13:23160542-23325165 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SGCG
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display abnormalities in muscles and heart similar to muscular dystrophy.
 
Human Diseases Modeled Using Mouse Sgcg (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(4)
Interactions
Sgcg interacts with 122 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process membrane organization
Component cytoplasm, cytoskeleton, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (36)    Tissues (16)    Images (22)
Theiler Stages: 23, 28
Assay TypeResults
RNA in situ 36
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(18)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000029985 (Evidence)
Ensembl Gene ModelENSMUSG00000035296 (Evidence)
Entrez Gene24053 (Evidence)
UniGene72173
DFCITC1585165, TC1600560
DoTSDT.101249626, DT.487828, DT.94316251
NIA Mouse Gene IndexU282519
Consensus CDS ProjectCCDS27181.1
International Mouse Knockout Project StatusSgcg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029985 VEGA Gene Model | MGI Sequence Detail 37432 C57BL/6J ±  kb
transcript OTTMUST00000074361 VEGA | MGI Sequence Detail 1571 Not Applicable 
polypeptide OTTMUSP00000038682 VEGA | MGI Sequence Detail 291 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(357 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006875 Sarcoglycan complex subunit protein
Protein Ontology PR:000014785 gamma-sarcoglycan
References (Earliest) J:49871 Hack AA, et al., Gamma-sarcoglycan deficiency leads to muscle membrane defects and apoptosis independent of dystrophin. J Cell Biol. 1998 Sep 7;142(5):1279-87
(Latest) J:208843 Swaggart KA, et al., Annexin A6 modifies muscular dystrophy by mediating sarcolemmal repair. Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):6004-9
All references(59)
Disease annotation references (6)
Other
accession IDs
MGI:1921755, MGI:2145683

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory