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Sgcg
Gene Detail
Symbol

Name
ID
Sgcg
sarcoglycan, gamma (dystrophin-associated glycoprotein)
MGI:1346524
Synonyms
5430420E18Rik, gamma-SG
Feature Type
protein coding gene
Genetic Map
Chromosome 14
32.27 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:61221059-61258490 bp, - strand
From VEGA annotation of GRCm38

  37432 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:194  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: SGCG
Protein SuperFamily: sarcoglycan, beta/gamma/delta/zeta types
Gene Tree: Sgcg

Human
homologs
SGCG, sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 6445
neXtProt AC: NX_Q13326

Human Synonyms: A4, DAGA4, DMDA, DMDA1, LGMD2C, MAM, SCARMD2, SCG3, TYPE

Human Chr (Location): 13q12; chr13:23160506-23325165 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SGCG

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display abnormalities in muscles and heart similar to muscular dystrophy.
 
Human Diseases Modeled in Mice Using Sgcg (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(4)
Interactions
Sgcg interacts with 122 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cardiac muscle tissue development, heart contraction, ...
Component cytoplasm, cytoskeleton, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (36)    Tissues (16)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 36
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase sgcg ; ZFIN sgcg    NEW 
Molecular
reagents
All nucleic(18) cDNA(18)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000029985 (Evidence)
Ensembl Gene Model ENSMUSG00000035296 (Evidence)
Entrez Gene 24053 (Evidence)
UniGene 72173
DFCI TC1600560, TC1585165
DoTS DT.94316251, DT.487828, DT.101249626
NIA Mouse Gene Index U282519
Consensus CDS Project CCDS27181.1
International Mouse Phenotyping Consortium Status Sgcg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029985 VEGA Gene Model | MGI Sequence Detail 37432 C57BL/6J ±  kb
transcript OTTMUST00000074361 VEGA | MGI Sequence Detail 1571 Not Applicable 
polypeptide OTTMUSP00000038682 VEGA | MGI Sequence Detail 291 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(357 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006875 Sarcoglycan complex subunit protein
Protein Ontology PR:000014785 gamma-sarcoglycan
References
(Earliest) J:49871 Hack AA, et al., Gamma-sarcoglycan deficiency leads to muscle membrane defects and apoptosis independent of dystrophin. J Cell Biol. 1998 Sep 7;142(5):1279-87
(Latest) J:216218 Goldstein JA, et al., Excess SMAD signaling contributes to heart and muscle dysfunction in muscular dystrophy. Hum Mol Genet. 2014 Dec 20;23(25):6722-31
All references(60)
Disease annotation references (6)
Other
accession IDs
MGI:1921755, MGI:2145683

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory