About   Help   FAQ
Sgcg Gene Detail
Summary
  • Symbol
    Sgcg
  • Name
    sarcoglycan, gamma (dystrophin-associated glycoprotein)
  • Synonyms
    5430420E18Rik, gamma-SG
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346524
    NCBI Gene: 24053
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:61456564-61495939 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 14, 32.27 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    361 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346524
protein coding gene Chr14:61456555-61495939 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021438
protein coding gene Chr14:55587104-55630434 (-)
A/J MGP_AJ_G0021397
protein coding gene Chr14:54379790-54419456 (-)
AKR/J MGP_AKRJ_G0021372
protein coding gene Chr14:56319097-56358796 (-)
BALB/cJ MGP_BALBcJ_G0021402
protein coding gene Chr14:54330378-54369930 (-)
C3H/HeJ MGP_C3HHeJ_G0021180
protein coding gene Chr14:55960767-55997420 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021841
protein coding gene Chr14:58306274-58347933 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019381
protein coding gene Chr14:52390090-52426209 (-)
CAST/EiJ MGP_CASTEiJ_G0020696
protein coding gene Chr14:52356068-52396070 (-)
CBA/J MGP_CBAJ_G0021147
protein coding gene Chr14:59982350-60026597 (-)
DBA/2J MGP_DBA2J_G0021270
protein coding gene Chr14:54044591-54084648 (-)
FVB/NJ MGP_FVBNJ_G0021248
protein coding gene Chr14:53472579-53513087 (-)
LP/J MGP_LPJ_G0021344
protein coding gene Chr14:56628799-56667085 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021277
protein coding gene Chr14:59295315-59338605 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021864
protein coding gene Chr14:55470453-55511426 (-)
PWK/PhJ MGP_PWKPhJ_G0020440
protein coding gene Chr14:50714509-50752383 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020273
protein coding gene Chr14:51408787-51443783 (-)
WSB/EiJ MGP_WSBEiJ_G0020749
protein coding gene Chr14:55791113-55829849 (-)



Homology
more
  • Human Ortholog
    SGCG, sarcoglycan gamma
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SGCG, sarcoglycan gamma
  • Synonyms
    35DAG, A4, DAGA4, DMDA, DMDA1, gamma-SG, LGMD2C, LGMDR5, MAM, SCARMD2, SCG3
  • Links
    NCBI Gene ID: 6445
    neXtProt AC: NX_Q13326
    UniProt: Q13326

  • Chr Location
    13q12.12; chr13:23160508-23325162 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with Sgcg mouse models; 2 with human SGCG associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotypes from multigenic genotypes
    4 images
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display abnormalities in muscles and heart similar to muscular dystrophy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035296 Ensembl Gene Model | MGI Sequence Detail 39376 C57BL/6J ±  kb
    transcript ENSMUST00000077954 Ensembl | MGI Sequence Detail 3515 Not Applicable  
    polypeptide ENSMUSP00000077106 Ensembl | MGI Sequence Detail 291 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 19

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1921755, MGI:2145683
    References
    more
    • Summaries
      All 81
      Developmental Gene Expression 9
      Diseases 5
      Gene Ontology 10
      Phenotypes 34
    • Earliest
      J:28976 Madhavan R, et al., Interactions between dystrophin glycoprotein complex proteins. Biochemistry. 1995 Sep 26;34(38):12204-9
    • Latest
      J:333147 Wu T, et al., Filamin C is Essential for mammalian myocardial integrity. PLoS Genet. 2023 Jan;19(1):e1010630

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory