Sgcg
Gene Detail

Symbol Name ID

Sgcg sarcoglycan, gamma (dystrophin-associated glycoprotein) MGI:1346524

Synonyms

5430420E18Rik, gamma-SG

Feature Type

protein coding gene

Genetic Map

Chromosome 14

32.27 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr14:61221059-61258490 bp, - strand From VEGA annotation of GRCm38   37432 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:194  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: sarcoglycan, beta/gamma/delta/zeta types
Gene Tree: Sgcg

Human homologs

Human Homolog		SGCG, sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
NCBI Gene ID		6445
neXtProt AC		NX_Q13326
Human Synonyms		A4, DAGA4, DMDA, DMDA1, LGMD2C, MAM, SCARMD2, SCG3, TYPE
Human Chr (Location)		13q12; chr13:23755060-23899304 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SGCG

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for disruptions in this gene display abnormalities in muscles and heart similar to muscular dystrophy.

 
Human Diseases Modeled Using Mouse Sgcg (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	cellular membrane organization
Component	cytoplasm, cytoskeleton, ...
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (36)    Tissues (16)    Images (22)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	36

cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(18) cDNA(18)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000029985 (Evidence)
Ensembl Gene Model	ENSMUSG00000035296 (Evidence)
Entrez Gene	24053 (Evidence)
UniGene	72173
DFCI	TC1585165, TC1600560
DoTS	DT.101249626, DT.487828, DT.94316251
NIA Mouse Gene Index	U282519
Consensus CDS Project	CCDS27181.1
International Mouse Knockout Project Status	Sgcg

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029985	VEGA Gene Model | MGI Sequence Detail	37432	C57BL/6J
transcript	OTTMUST00000074362	VEGA | MGI Sequence Detail	1298	Not Applicable
polypeptide	OTTMUSP00000038683	VEGA | MGI Sequence Detail	291	Not Applicable

All sequences(38) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(148 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006875	Sarcoglycan complex subunit protein
Protein Ontology	PR:000014785	gamma-sarcoglycan

References

(Earliest) J:49871 Hack AA, et al., Gamma-sarcoglycan deficiency leads to muscle membrane defects and apoptosis independent of dystrophin. J Cell Biol. 1998 Sep 7;142(5):1279-87
(Latest) J:175721 Townsend D, et al., Distinct pathophysiological mechanisms of cardiomyopathy in hearts lacking dystrophin or the sarcoglycan complex. FASEB J. 2011 Sep;25(9):3106-14
All references(56)

Other accession IDs

MGI:1921755, MGI:2145683