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Ddr2
Gene Detail
 Symbol
Name
ID
Ddr2
discoidin domain receptor family, member 2
MGI:1345277
Synonyms Ntrkr3
Feature Type protein coding gene
Genetic Map
Chromosome 1
76.84 cM, cytoband H1-H5
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr1:169972307-170088944 bp, - strand
From NCBI annotation of GRCm38

  116638 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68505  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: discoidin domain-containing receptor
Gene Tree: Ddr2

Human
homologs
Human Homolog DDR2, discoidin domain receptor tyrosine kinase 2
NCBI Gene ID 4921
neXtProt AC  NX_Q16832
Human Synonyms  MIG20a, NTRKR3, TKT, TYRO10
Human Chr (Location)  1q23.3; chr1:162631265-162786619 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human DDR2
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit dwarfism, shortening of the long bones with reduced chondrocyte proliferation, and generally reduced cell proliferation.
 
Human Diseases Modeled Using Mouse Ddr2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Ddr2 interacts with 459 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process biomineral tissue development, cell adhesion, ...
Component apical plasma membrane, extracellular vesicular exosome, ...
Function ATP binding, collagen binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (222)    Tissues (155)    Images (45)
Theiler Stages: 17, 19, 21, 23, 25, 28
Assay TypeResults
RNA in situ 222
cDNA source data(80)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(80) cDNA(80)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000026674 (Evidence)
Entrez Gene18214 (Evidence)
UniGene229249
NIA Mouse Gene IndexU022029
EC2.7.10.1
Consensus CDS ProjectCCDS48436.1
International Mouse Knockout Project StatusDdr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18214 NCBI Gene Model | MGI Sequence Detail 116638 C57BL/6J ±  kb
transcript NM_022563 RefSeq | MGI Sequence Detail 8306 C57BL/6 
polypeptide Q62371 UniProt | EBI | MGI Sequence Detail 854 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(8) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(1552 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000421 Coagulation factor 5/8 C-terminal type domain
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
Protein Ontology PR:000001446 discoidin domain-containing receptor 2
Graphical View of Protein Domain Structure
References (Earliest) J:18515 Lai C, et al., An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system. Neuron. 1991 May;6(5):691-704
(Latest) J:208068 Zhang S, et al., A host deficiency of discoidin domain receptor 2 (DDR2) inhibits both tumour angiogenesis and metastasis. J Pathol. 2014 Mar;232(4):436-48
All references(60)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-19589, MGI:102686, MGI:2138594

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory