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Ddr2
Gene Detail
Symbol

Name
ID
Ddr2
discoidin domain receptor family, member 2
MGI:1345277
Synonyms
Ntrkr3
Feature Type
protein coding gene
Genetic Map
Chromosome 1
76.84 cM, cytoband H1-H5
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr1:169972307-170110762 bp, - strand
From VEGA annotation of GRCm38

  138456 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68505  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DDR2
Protein SuperFamily: discoidin domain-containing receptor
Gene Tree: Ddr2

Human
homologs
DDR2, discoidin domain receptor tyrosine kinase 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4921
neXtProt AC: NX_Q16832

Human Synonyms: MIG20a, NTRKR3, TKT, TYRO10

Human Chr (Location): 1q23.3; chr1:162631265-162786591 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human DDR2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a targeted null mutation exhibit dwarfism, shortening of the long bones with reduced chondrocyte proliferation, and generally reduced cell proliferation.
 
Human Diseases Modeled in Mice Using Ddr2 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(1)
Interactions
Ddr2 interacts with 458 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process biomineral tissue development, chondrocyte proliferation, ...
Component apical plasma membrane, extracellular exosome, ...
Function ATP binding, collagen binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (222)    Tissues (155)    Images (45)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 222
cDNA source data(80)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA DDR2 ; Xenbase ddr2    NEW 
Molecular
reagents
All nucleic(80) cDNA(80)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000049937 (Evidence)
Ensembl Gene Model ENSMUSG00000026674 (Evidence)
Entrez Gene 18214 (Evidence)
UniGene 229249
NIA Mouse Gene Index U022029
EC 2.7.10.1
Consensus CDS Project CCDS48436.1
International Mouse Phenotyping Consortium Status Ddr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049937 VEGA Gene Model | MGI Sequence Detail 138456 C57BL/6J ±  kb
transcript OTTMUST00000127112 VEGA | MGI Sequence Detail 8590 Not Applicable 
polypeptide OTTMUSP00000068667 VEGA | MGI Sequence Detail 854 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(8) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(1805 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000421 Coagulation factor 5/8 C-terminal type domain
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
Protein Ontology PR:000001446 discoidin domain-containing receptor 2
References
(Earliest) J:18515 Lai C, et al., An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system. Neuron. 1991 May;6(5):691-704
(Latest) J:214642 Cowling RT, et al., Discoidin domain receptor 2 germline gene deletion leads to altered heart structure and function in the mouse. Am J Physiol Heart Circ Physiol. 2014 Sep 1;307(5):H773-81
All references(62)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-19589, MGI:102686, MGI:2138594

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory