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Spry2 Gene Detail
Summary
  • Symbol
    Spry2
  • Name
    sprouty RTK signaling antagonist 2
  • Synonyms
    sprouty2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345138
    NCBI Gene: 24064
  • Gene Overview
    MyGene.info: SPRY2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:105891947-105896819 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4873 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 56.16 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SPRY2, sprouty RTK signaling antagonist 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SPRY2, sprouty RTK signaling antagonist 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    hSPRY2, IGAN3
  • Links
    NCBI Gene ID: 10253
    neXtProt AC: NX_O43597
    UniProt: O43597

  • Chr Location
    13q31.1; chr13:80335976-80341115 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Spry2 mouse models; 1 with human SPRY2 associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 4 alleles in 4 genetic backgrounds
    24 phenotypes from multigenic genotypes
    63 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit enteric nerve hyperplasia which led to esophangeal achalasia and intestinal pseudo-obstruction. Mice also have intermediate to severe hearing loss with abnormalities in the organ of Corti and about half die prematurely.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 24064 NCBI Gene Model | MGI Sequence Detail 4873 C57BL/6J ±  kb
    transcript NM_011897 RefSeq | MGI Sequence Detail 2103 C57BL/6  
    polypeptide Q9QXV8 UniProt | EBI | MGI Sequence Detail 315 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      19 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 14
      Primer pair 3
      Other 4

      Microarray probesets 4
    References
    more
    • Summaries
      All 249
      Developmental Gene Expression 166
      Diseases 3
      Gene Ontology 13
      Phenotypes 63
    • Earliest
      J:19710 Editors of Human Genome 1994, et al., Human genetic Disorders. J NIH Res. 1994;6:115-134
    • Latest
      J:263185 Huang M, et al., Multiple roles of epithelial heparan sulfate in stomach morphogenesis. J Cell Sci. 2018 May 29;131(10)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory