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Spry2
Gene Detail
Symbol

Name
ID
Spry2
sprouty homolog 2 (Drosophila)
MGI:1345138
Synonyms
sprouty2
Feature Type
protein coding gene
Genetic Map
Chromosome 14
56.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:105891949-105896819 bp, - strand
From Ensembl annotation of GRCm38

  4871 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4267  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: sprouty homolog protein
Gene Tree: Spry2

Human
homologs
Human Homolog SPRY2, sprouty homolog 2 (Drosophila)
NCBI Gene ID 10253
neXtProt AC  NX_O43597
Human Synonyms  hSPRY2
Human Chr (Location)  13q31.1; chr13:80335976-80340968 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Gene trapped(25) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit enteric nerve hyperplasia which led to esophangeal achalasia and intestinal pseudo-obstruction. Mice also have intermediate to severe hearing loss with abnormalities in the organ of Corti and about half die prematurely.
 
Human Diseases Modeled Using Mouse Spry2 (3)    Alleles Annotated to Human Diseases(3)   
Interactions
Spry2 interacts with 223 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process branching morphogenesis of an epithelial tube, bud elongation involved in lung branching, ...
Component cell, cell projection, ...
Function protein binding, protein kinase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (128 records)
Data Summary: Results (224)    Tissues (181)    Images (61)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 204
Northern blot 13
Western blot 3
RT-PCR 4
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(13) Primer pair(1) Other(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000022114 (Evidence)
Entrez Gene24064 (Evidence)
DFCITC1590967, TC1619632
DoTSDT.101337689, DT.526071
NIA Mouse Gene IndexU035894
Consensus CDS ProjectCCDS27321.1
International Mouse Knockout Project StatusSpry2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022114 Ensembl Gene Model | MGI Sequence Detail 4871 C57BL/6J ±  kb
transcript ENSMUST00000022709 Ensembl | MGI Sequence Detail 2085 Not Applicable 
polypeptide ENSMUSP00000022709 Ensembl | MGI Sequence Detail 315 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(19 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007875 Sprouty
Protein Ontology PR:000015583 protein sprouty homolog 2
References
(Earliest) J:19710 Editors of Human Genome 1994, et al., Human genetic Disorders. J NIH Res. 1994;6:115-134
(Latest) J:206582 Ching ST, et al., Coordinated activity of Spry1 and Spry2 is required for normal development of the external genitalia. Dev Biol. 2014 Feb 1;386(1):1-11
All references(191)
Disease annotation references (2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory