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Spry2 Gene Detail
Summary
  • Symbol
    Spry2
  • Name
    sprouty RTK signaling antagonist 2
  • Synonyms
    sprouty2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345138
    NCBI Gene: 24064
  • Gene Overview
    MyGene.info: SPRY2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:105891947-105896819 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 56.16 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    19 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345138
protein coding gene Chr14:105891947-105896819 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021638
protein coding gene Chr14:102484242-102492082 (-)
A/J MGP_AJ_G0021596
protein coding gene Chr14:99103875-99108737 (-)
AKR/J MGP_AKRJ_G0021572
protein coding gene Chr14:102078071-102082942 (-)
BALB/cJ MGP_BALBcJ_G0021602
protein coding gene Chr14:99457648-99462510 (-)
C3H/HeJ MGP_C3HHeJ_G0021380
protein coding gene Chr14:102008404-102016676 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022042
protein coding gene Chr14:106604157-106609886 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019582
protein coding gene Chr14:95851108-95855898 (-)
CAST/EiJ MGP_CASTEiJ_G0020897
protein coding gene Chr14:99335434-99340194 (-)
CBA/J MGP_CBAJ_G0021348
protein coding gene Chr14:110425726-110430556 (-)
DBA/2J MGP_DBA2J_G0021472
protein coding gene Chr14:98616743-98621578 (-)
FVB/NJ MGP_FVBNJ_G0021449
protein coding gene Chr14:97549098-97553941 (-)
LP/J MGP_LPJ_G0021540
protein coding gene Chr14:103324503-103329346 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021476
protein coding gene Chr14:113271989-113276872 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022065
protein coding gene Chr14:101599850-101604725 (-)
PWK/PhJ MGP_PWKPhJ_G0020640
protein coding gene Chr14:95556240-95561292 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020478
protein coding gene Chr14:97592479-97599420 (-)
WSB/EiJ MGP_WSBEiJ_G0020950
protein coding gene Chr14:102218636-102223497 (-)



Homology
more
  • Human Ortholog
    SPRY2, sprouty RTK signaling antagonist 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SPRY2, sprouty RTK signaling antagonist 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hSPRY2, IGAN3
  • Links
    NCBI Gene ID: 10253
    neXtProt AC: NX_O43597
    UniProt: O43597

  • Chr Location
    13q31.1; chr13:80335976-80341115 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Spry2 mouse models; 1 with human SPRY2 associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 4 alleles in 4 genetic backgrounds
    24 phenotypes from multigenic genotypes
    65 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit enteric nerve hyperplasia which led to esophangeal achalasia and intestinal pseudo-obstruction. Mice also have intermediate to severe hearing loss with abnormalities in the organ of Corti and about half die prematurely.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 24064 NCBI Gene Model | MGI Sequence Detail 4873 C57BL/6J ±  kb
    transcript NM_011897 RefSeq | MGI Sequence Detail 2103 C57BL/6  
    polypeptide Q9QXV8 UniProt | EBI | MGI Sequence Detail 315 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 14
      Primer pair 3
      Other 4

      Microarray probesets 4
    References
    more
    • Summaries
      All 251
      Developmental Gene Expression 166
      Diseases 3
      Gene Ontology 14
      Phenotypes 65
    • Earliest
      J:19710 Editors of Human Genome 1994, et al., Human genetic Disorders. J NIH Res. 1994;6:115-134
    • Latest
      J:265930 Shehata HM, et al., Lack of Sprouty 1 and 2 enhances survival of effector CD8(+) T cells and yields more protective memory cells. Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):E8939-E8947

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory