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Spry2
Gene Detail
Symbol

Name
ID
Spry2
sprouty homolog 2 (Drosophila)
MGI:1345138
Synonyms
sprouty2
Feature Type
protein coding gene
Genetic Map
Chromosome 14
56.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:105891949-105896819 bp, - strand
From Ensembl annotation of GRCm38

  4871 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4267  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SPRY2
Protein SuperFamily: sprouty homolog protein
Gene Tree: Spry2

Human
homologs
SPRY2, sprouty RTK signaling antagonist 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 10253
neXtProt AC: NX_O43597

Human Synonyms: hSPRY2

Human Chr (Location): 13q31.1; chr13:80335976-80340951 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Gene trapped(25) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit enteric nerve hyperplasia which led to esophangeal achalasia and intestinal pseudo-obstruction. Mice also have intermediate to severe hearing loss with abnormalities in the organ of Corti and about half die prematurely.
 
Human Diseases Modeled in Mice Using Spry2 (2)    Mutations Annotated to Human Diseases (3)   
Interactions
Spry2 interacts with 222 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (48 annotations)
Process activation of protein kinase activity, branching morphogenesis of an epithelial tube, ...
Component cell, cell projection, ...
Function protein binding, protein kinase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (136 records)
Data Summary: Results (241)    Tissues (194)    Images (72)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 220
Northern blot 13
Western blot 3
RT-PCR 5
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA SPRY2 ; Xenbase spry2 ; ZFIN spry2    NEW 
Molecular
reagents
All nucleic(18) cDNA(13) Primer pair(2) Other(3)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000022114 (Evidence)
Entrez Gene 24064 (Evidence)
DFCI TC1619632, TC1590967
DoTS DT.526071, DT.101337689
NIA Mouse Gene Index U035894
Consensus CDS Project CCDS27321.1
International Mouse Phenotyping Consortium Status Spry2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022114 Ensembl Gene Model | MGI Sequence Detail 4871 C57BL/6J ±  kb
transcript ENSMUST00000022709 Ensembl | MGI Sequence Detail 2085 Not Applicable 
polypeptide ENSMUSP00000022709 Ensembl | MGI Sequence Detail 315 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(19 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007875 Sprouty
Protein Ontology PR:000015583 protein sprouty homolog 2
References
(Earliest) J:19710 Editors of Human Genome 1994, et al., Human genetic Disorders. J NIH Res. 1994;6:115-134
(Latest) J:221422 Lochovska K, et al., Sprouty gene dosage influences temporal-spatial dynamics of primary enamel knot formation. BMC Dev Biol. 2015;15:21
All references(200)
Disease annotation references (2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory