Spry2
Gene Detail

Symbol Name ID

Spry2 sprouty homolog 2 (Drosophila) MGI:1345138

Synonyms

sprouty2

Feature Type

protein coding gene

Genetic Map

Chromosome 14

56.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr14:105891949-105896819 bp, - strand From Ensembl annotation of GRCm38   4871 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Spry2 ± 2 cM)

Protein SuperFamily: sprouty homolog protein
Gene Tree: Spry2

Human ortholog

SPRY2 sprouty homolog 2 (Drosophila) NCBI Gene ID 10253
Human Synonyms: hSPRY2
Human Chr13:80910111-80915086 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(30) : Targeted(5) Gene trapped(25)
 

Homozygous null mice exhibit enteric nerve hyperplasia which led to esophangeal achalasia and intestinal pseudo-obstruction. Mice also have intermediate to severe hearing loss with abnormalities in the organ of Corti and about half die prematurely.

 
Human Diseases Modeled Using Mouse Spry2 (4)    Alleles Annotated to Human Diseases(3)   

Gene Ontology (GO) classifications

All GO classifications: (40 annotations)

Process	branching morphogenesis of an epithelial tube, cell fate commitment, ...
Component	cell projection, cytoplasm, ...
Function	protein binding, protein kinase binding, ...

External Resources: FuncBase

Expression

Literature Summary: (115 records)
Data Summary: Results (208)    Tissues (173)    Images (46)
Theiler Stages: 9, 11, 12, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 28

Assay Type	Results
RNA in situ	188
Northern blot	13
Western blot	3
RT-PCR	4

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) cDNA(12) Primer pair(1) Other(2)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000022114 (Evidence)
Entrez Gene	24064 (Evidence)
DFCI	TC1590967, TC1619632
DoTS	DT.101337689, DT.526071
NIA Mouse Gene Index	U035894
Consensus CDS Project	CCDS27321.1
International Mouse Knockout Project Status	Spry2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000022114	Ensembl Gene Model | MGI Sequence Detail	4871	C57BL/6J
transcript	ENSMUST00000022709	Ensembl | MGI Sequence Detail	2085	Not Applicable
polypeptide	ENSMUSP00000022709	Ensembl | MGI Sequence Detail	315	Not Applicable

All sequences(22) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(9 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007875	Sprouty
Protein Ontology	PR:000015583	protein sprouty 2

References

(Earliest) J:53234 Tefft JD, et al., Conserved function of mSpry-2, a murine homolog of Drosophila sprouty, which negatively modulates respiratory organogenesis. Curr Biol. 1999 Feb 25;9(4):219-22
(Latest) J:192348 Schutzman JL, et al., Sprouty genes function in suppression of prostate tumorigenesis. Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):20023-8
All references(171)