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Spry2 Gene Detail
Summary
  • Symbol
    Spry2
  • Name
    sprouty homolog 2 (Drosophila)
  • Synonyms
    sprouty2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345138
    NCBI Gene: 24064
Location & Maps
more
  • Sequence Map
    Chr14:105891949-105896819 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4871 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SPRY2, sprouty RTK signaling antagonist 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SPRY2, sprouty RTK signaling antagonist 2
    Orthology source: HomoloGene
  • Synonyms
    hSPRY2
  • Links
    NCBI Gene ID: 10253
    neXtProt AC: NX_O43597

  • Chr Location
    13q31.1; chr13:80335976-80340951 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Spry2 mouse models

Human Disease Mouse Models
       Achalasia, Familial Esophageal   OMIM: 200400 View 1 model
Neuronal Intestinal Dysplasia, Type B   OMIM: 601223 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 4 alleles in 4 genetic backgrounds
    24 phenotypes from multigenic genotypes
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    35
  • Chemically induced (other)
    1
  • Gene trapped
    25
  • Radiation induced
    1
  • Targeted
    5
  • Transgenic
    3
  • Genomic Mutations
    2 involving Spry2
  • Incidental Mutations
Homozygous null mice exhibit enteric nerve hyperplasia which led to esophangeal achalasia and intestinal pseudo-obstruction. Mice also have intermediate to severe hearing loss with abnormalities in the organ of Corti and about half die prematurely.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022114 Ensembl Gene Model | MGI Sequence Detail 4871 C57BL/6J ±  kb
transcript ENSMUST00000022709 Ensembl | MGI Sequence Detail 2085 Not Applicable  
polypeptide ENSMUSP00000022709 Ensembl | MGI Sequence Detail 315 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    19 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 13
    Primer pair 2
    Other 3

    Microarray probesets 4
References
more
  • Summaries
    All 203
    Developmental Gene Expression 140
    Diseases 4
    Gene Ontology 11
    Phenotypes 53
  • Earliest
    J:19710 Editors of Human Genome 1994, et al., Human genetic Disorders. J NIH Res. 1994;6:115-134
  • Latest
    J:226692 Wright KD, et al., Cooperative and independent functions of FGF and Wnt signaling during early inner ear development. BMC Dev Biol. 2015;15:33

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory