Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables ubiquitin-protein transferase inhibitor activity. Involved in several processes, including negative regulation of cell differentiation; negative regulation of cell projection organization; and regulation of signal transduction. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; lung development; and negative regulation of signal transduction. Located in several cellular components, including cytoskeleton; cytosol; and nucleus. Is expressed in several structures, including alimentary system; embryo mesenchyme; epithelium; future brain; and genitourinary system. Used to study achalasia; ciliopathy; intestinal pseudo-obstruction; and prostate cancer. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human SPRY2 (sprouty RTK signaling antagonist 2).