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Ldb3
Gene Detail
 Symbol
Name
ID
Ldb3
LIM domain binding 3
MGI:1344412
Synonyms cypher, ZASP
Feature Type protein coding gene
Genetic Map
Chromosome 14
20.83 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:34526699-34588681 bp, - strand
From NCBI annotation of GRCm38

  61983 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:134626  Vertebrate Homology Class
1 human; 1 mouse; 1 dog; 1 chicken

Gene Tree: Ldb3

Human
homologs
Human Homolog LDB3, LIM domain binding 3
NCBI Gene ID 11155
neXtProt AC  NX_O75112
Human Synonyms  CMD1C, CMPD3, CYPHER, LDB3Z1, LDB3Z4, LVNC3, MFM4, ORACLE, PDLIM6, ZASP
Human Chr (Location)  10q22.3-q23.2; chr10:86666717-86736072 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human LDB3
Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(11) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in lethality within a few days after birth from muscle abnormalities. Mutant mice exhibit myopathy, dysphagia, heart vascular congestion, dilated heart ventricles, cyanosis, and respiratory distress.
 
Human Diseases Modeled Using Mouse Ldb3 (3)    Alleles Annotated to Human Diseases(2)    Phenotype Images(3)
Interactions
Ldb3 interacts with 284 markers (Mir7-1, Mir7-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process sarcomere organization
Component cell projection, cytoplasm, ...
Function cytoskeletal protein binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (274)    Tissues (197)    Images (49)
Theiler Stages: 17, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 203
Northern blot 32
Western blot 16
RT-PCR 23
cDNA source data(74)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(81) cDNA(76) Primer pair(5)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000021798 (Evidence)
Entrez Gene24131 (Evidence)
UniGene29733
DFCITC1578543, TC1587042, TC1593969, TC1596270, TC1597554, TC1706854, TC1759727
DoTSDT.101163060, DT.101214523, DT.101289502, DT.101407772, DT.101407773, DT.494178, DT.91376521, DT.94398362
NIA Mouse Gene IndexU035414
PDB1WJL
Consensus CDS ProjectCCDS26940.1, CCDS26941.1, CCDS26942.1, CCDS36878.1, CCDS36879.1
International Mouse Knockout Project StatusLdb3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 24131 NCBI Gene Model | MGI Sequence Detail 61983 C57BL/6J ±  kb
transcript NM_011918 RefSeq | MGI Sequence Detail 5040 C57BL/6 
polypeptide Q9JKS4 UniProt | EBI | MGI Sequence Detail 723 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(20) UniProt(3)
Polymorphisms SNPs within 2kb(608 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001478 PDZ domain
InterPro IPR006643 ZASP
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000009738 LIM domain-binding protein 3
Graphical View of Protein Domain Structure
References (Earliest) J:55277 Faulkner G, et al., ZASP: a new Z-band alternatively spliced PDZ-motif protein. J Cell Biol. 1999 Jul 26;146(2):465-75
(Latest) J:187997 Chamberlain CM, et al., Mouse model of muscleblind-like 1 overexpression: skeletal muscle effects and therapeutic promise. Hum Mol Genet. 2012 Nov 1;21(21):4645-54
All references(49)
Disease annotation references (2)
Other
accession IDs
MGI:2145842

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory