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Ldb3
Gene Detail
Symbol

Name
ID
Ldb3
LIM domain binding 3
MGI:1344412
Synonyms
cypher, ZASP
Feature Type
protein coding gene
Genetic Map
Chromosome 14
20.83 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:34526699-34588681 bp, - strand
From Ensembl annotation of GRCm38

  61983 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:134626  Vertebrate Homology Class
1 human; 1 mouse; 1 dog; 1 chicken

HCOP human homology predictions: LDB3
Gene Tree: Ldb3

Human
homologs
LDB3, LIM domain binding 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 11155
neXtProt AC: NX_O75112

Human Synonyms: CMD1C, CMH24, CMPD3, CYPHER, LDB3Z1, LDB3Z4, LVNC3, MFM4, ORACLE, PDLIM6, ZASP

Human Chr (Location): 10q22.3-q23.2; chr10:86666717-86736072 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LDB3

Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(11) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in lethality within a few days after birth from muscle abnormalities. Mutant mice exhibit myopathy, dysphagia, heart vascular congestion, dilated heart ventricles, cyanosis, and respiratory distress.
 
Human Diseases Modeled in Mice Using Ldb3 (3)    Mutations Annotated to Human Diseases (2)    Phenotype Images(3)
Interactions
Ldb3 interacts with 284 markers (Mir7-1, Mir7-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process sarcomere organization
Component cell projection, cytoplasm, ...
Function cytoskeletal protein binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (268)    Tissues (192)    Images (49)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 197
Northern blot 32
Western blot 16
RT-PCR 23
cDNA source data(74)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ldb3    NEW 
Molecular
reagents
All nucleic(81) cDNA(76) Primer pair(5)
Microarray probesets(7)
Other database
links
Ensembl Gene Model ENSMUSG00000021798 (Evidence)
Entrez Gene 24131 (Evidence)
UniGene 29733
DFCI TC1587042, TC1578543, TC1597554, TC1596270, TC1593969, TC1706854, TC1759727
DoTS DT.101407772, DT.101214523, DT.101289502, DT.101163060, DT.101407773, DT.91376521, DT.494178, DT.94398362
NIA Mouse Gene Index U035414
PDB 1WJL
Consensus CDS Project CCDS26940.1, CCDS26941.1, CCDS26942.1, CCDS36878.1, CCDS36879.1
International Mouse Phenotyping Consortium Status Ldb3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021798 Ensembl Gene Model | MGI Sequence Detail 61983 C57BL/6J ±  kb
transcript ENSMUST00000022327 Ensembl | MGI Sequence Detail 5040 Not Applicable 
polypeptide ENSMUSP00000022327 Ensembl | MGI Sequence Detail 723 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(20) UniProt(3)
Polymorphisms
SNPs within 2kb(608 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001478 PDZ domain
InterPro IPR006643 ZASP
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000009738 LIM domain-binding protein 3
References
(Earliest) J:55277 Faulkner G, et al., ZASP: a new Z-band alternatively spliced PDZ-motif protein. J Cell Biol. 1999 Jul 26;146(2):465-75
(Latest) J:204536 Lin C, et al., Cypher/ZASP is a novel A-kinase anchoring protein. J Biol Chem. 2013 Oct 11;288(41):29403-13
All references(50)
Disease annotation references (2)
Other
accession IDs
MGI:2145842

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory