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Phenotypes Associated with This Genotype
Genotype
MGI:3832390
Allelic
Composition		 Ldb3tm4Chen/Ldb3tm4Chen
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cfTg(Myh6-cre/Esr1*)1Jmk mutation (5 available); any A1cf mutation (37 available)
Ldb3tm4Chen mutation (0 available); any Ldb3 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:144739 )
• all mice die between 1 and 16 weeks after tamoxifen treatment

cardiovascular system
enlarged heart ( J:144739 )
• after tamoxifen treatment
dilated heart left ventricle ( J:144739 )
• both ventricles are severely dilated after tamoxifen treatment
dilated heart right ventricle ( J:144739 )
• both ventricles are severely dilated after tamoxifen treatment
abnormal cardiovascular system physiology ( J:144739 )
• decreased heart function one month after tamoxifen treatment
dilated cardiomyopathy ( J:144739 )
• after tamoxifen treatment

muscle
dilated cardiomyopathy ( J:144739 )
• after tamoxifen treatment

growth/size/body
enlarged heart ( J:144739 )
• after tamoxifen treatment

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
dilated cardiomyopathy 1C DOID:0110423 OMIM:601493
 J:144739

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory