Symbol
Name
ID

Ldb3
LIM domain binding 3
MGI:1344412

Phenotype annotations related to muscle

Darker colors indicate more annotations

Human Phenotypes

Calf muscle pseudohypertrophy

Proximal upper limb muscle weakness

Distal lower limb muscle weakness

EMG: myopathic abnormalities

EMG: neuropathic changes

Difficulty running

Muscle stiffness

Progressive distal muscle weakness

Progressive muscle weakness

Progressive proximal muscle weakness

Autophagic vacuoles

Muscle fiber splitting

Myofibrillar myopathy

Rhabdomyolysis

Distal amyotrophy

Disease(s) Associated with LDB3

distal myopathy

myofibrillar myopathy 4

Mouse Phenotypes

abnormal myocardium layer morphology

abnormal myocardial fiber morphology

abnormal myocardial fiber mitochondrial morphology

dilated cardiomyopathy

decreased cardiac muscle contractility

abnormal Z line morphology

skeletal muscle fiber atrophy

increased variability of skeletal muscle fiber size

abnormal skeletal muscle morphology

muscle weakness

myopathy

Availability

Mouse Genotype

Ldb3^tm1Chen/Ldb3^tm1Chen

Ldb3^tm2Chen/Ldb3^tm2Chen

Ldb3^tm3Chen/Ldb3^tm3Chen

Ldb3^tm6.2Chen/Ldb3^tm6.2Chen

Ldb3^tm4Chen/Ldb3^tm4Chen
Myl2^tm1(cre)Krc/Myl2⁺ (conditional)

Ldb3^tm4Chen/Ldb3^tm4Chen
A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/24/2026 MGI 6.24