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Tnfsf13b
Gene Detail
Symbol

Name
ID
Tnfsf13b
tumor necrosis factor (ligand) superfamily, member 13b
MGI:1344376
Synonyms
BAFF, BLyS, D8Ertd387e, TALL-1, zTNF4
Feature Type
protein coding gene
Genetic Map
Chromosome 8
4.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr8:10006843-10035441 bp, + strand
From Ensembl annotation of GRCm38

  28599 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48443  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tumor necrosis factor ligand superfamily member 13B
Gene Tree: Tnfsf13b

Human
homologs
Human Homolog TNFSF13B, tumor necrosis factor (ligand) superfamily, member 13b
NCBI Gene ID 10673
neXtProt AC  NX_Q9Y275
Human Synonyms  BAFF, BLYS, CD257, DTL, TALL1, TALL-1, THANK, TNFSF20, ZTNF4
Human Chr (Location)  13q32-q34; chr13:108269527-108308484 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice have reduced number of B cells and reduced levels of immunoglobulins.
 
Interactions
Tnfsf13b interacts with 12 markers (Mir466d, Mir466i, Mir466k, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process B cell costimulation, B cell homeostasis, ...
Component cell, cytoplasm, ...
Function cytokine activity, tumor necrosis factor receptor binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (27)    Tissues (18)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
RT-PCR 3
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(14) Primer pair(2)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000031497 (Evidence)
Entrez Gene24099 (Evidence)
DFCITC1607586, TC1594278, TC1585439, TC1593299
DoTSDT.91316439, DT.94134302, DT.101145480, DT.489089, DT.94237608
NIA Mouse Gene IndexU009066
Consensus CDS ProjectCCDS22094.1
International Mouse Knockout Project StatusTnfsf13b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031497 Ensembl Gene Model | MGI Sequence Detail 28599 C57BL/6J ±  kb
transcript ENSMUST00000033892 Ensembl | MGI Sequence Detail 930 Not Applicable 
polypeptide ENSMUSP00000033892 Ensembl | MGI Sequence Detail 309 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(11) UniProt(11)
Polymorphisms
SNPs within 2kb(176 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006052 Tumour necrosis factor
InterPro IPR008983 Tumour necrosis factor-like domain
Protein Ontology PR:000001948 tumor necrosis factor ligand superfamily member 13B
References
(Earliest) J:55624 Schneider P, et al., BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J Exp Med. 1999 Jun 7;189(11):1747-56
(Latest) J:209374 Marino E, et al., BAFF regulates activation of self-reactive T cells through B-cell dependent mechanisms and mediates protection in NOD mice. Eur J Immunol. 2014 Apr;44(4):983-93
All references(82)
Other
accession IDs
MGI:1196237

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory