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Mpdz Gene Detail
Summary
  • Symbol
    Mpdz
  • Name
    multiple PDZ domain protein
  • Synonyms
    B930003D11Rik, MUPP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343489
    NCBI Gene: 17475
  • Gene Overview
    MyGene.info: MPDZ
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:81278500-81442815 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 38.00 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1365 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1343489
protein coding gene Chr4:81278499-81442914 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028397
protein coding gene Chr4:80842102-80999234 (-)
A/J MGP_AJ_G0028358
protein coding gene Chr4:78028360-78180965 (-)
AKR/J MGP_AKRJ_G0028307
protein coding gene Chr4:80026257-80189496 (-)
BALB/cJ MGP_BALBcJ_G0028378
protein coding gene Chr4:78278778-78437281 (-)
C3H/HeJ MGP_C3HHeJ_G0028093
protein coding gene Chr4:80625682-80794792 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028817
protein coding gene Chr4:84019951-84183249 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026117
protein coding gene Chr4:74033386-74180599 (-)
CAST/EiJ MGP_CASTEiJ_G0027534
protein coding gene Chr4:78573783-78730781 (-)
CBA/J MGP_CBAJ_G0028062
protein coding gene Chr4:86623055-86793071 (-)
DBA/2J MGP_DBA2J_G0028211
protein coding gene Chr4:77795806-77954135 (-)
FVB/NJ MGP_FVBNJ_G0028177
protein coding gene Chr4:76783660-76942797 (-)
LP/J MGP_LPJ_G0028311
protein coding gene Chr4:81176538-81335343 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028206
protein coding gene Chr4:91709934-91875810 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028854
protein coding gene Chr4:80075183-80227021 (-)
PWK/PhJ MGP_PWKPhJ_G0027257
protein coding gene Chr4:76166268-76331757 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027082
protein coding gene Chr4:77627213-77783836 (-)
WSB/EiJ MGP_WSBEiJ_G0027610
protein coding gene Chr4:80265584-80429066 (-)



Homology
more
  • Human Ortholog
    MPDZ, multiple PDZ domain crumbs cell polarity complex component
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MPDZ, multiple PDZ domain crumbs cell polarity complex component
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HYC2, MUPP1
  • Links
    NCBI Gene ID: 8777
    neXtProt AC: NX_O75970
    UniProt: O75970

  • Chr Location
    9p23; chr9:13105296-13279687 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2841
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MPDZ
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human MPDZ associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    1
  • Gene trapped
    2
  • Radiation induced
    1
  • Transgenic
    1
  • Genomic Mutations
    3 involving Mpdz
  • Incidental Mutations
  • Find Mice (IMSR)
Mutant heterozygous mice are more sensitive to ethanol withdrawal effects and consume less alcohol than controls.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028402 Ensembl Gene Model | MGI Sequence Detail 164316 C57BL/6J ±  kb
transcript ENSMUST00000220807 Ensembl | MGI Sequence Detail 6295 Not Applicable  
polypeptide ENSMUSP00000152533 Ensembl | MGI Sequence Detail 2069 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 14
    Primer pair 2

    Microarray probesets 8
Other
Accession IDs
less
MGI:2140210
References
more
  • Summaries
    All 66
    Developmental Gene Expression 10
    Gene Ontology 11
    Phenotypes 10
  • Earliest
    J:56256 Simpson EH, et al., Identification, sequence, and mapping of the mouse multiple PDZ domain protein gene, Mpdz. Genomics. 1999 Jul 1;59(1):102-4
  • Latest
    J:260419 Jiang X, et al., Asymmetric distribution of CRUMBS polarity complex proteins from compacted 8-cell to blastocyst stage during mouse preimplantation development. Gene Expr Patterns. 2018 Jan;27:93-98

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory