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Ikzf1
Gene Detail
Symbol

Name
ID
Ikzf1
IKAROS family zinc finger 1
MGI:1342540
Synonyms
5832432G11Rik, Ikaros, LyF-1, Zfpn1a1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
7.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:11685003-11772112 bp, + strand
From VEGA annotation of GRCm38

  87110 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55948  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: IKZF1
Protein SuperFamily: ikaros-related zinc finger transcription factor
Gene Tree: Ikzf1

Human
homologs
IKZF1, IKAROS family zinc finger 1 (Ikaros)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 10320
neXtProt AC: NX_Q13422

Human Synonyms: Hs.54452, IK1, IKAROS, LyF-1, LYF1, PPP1R92, PRO0758, ZNFN1A1

Human Chr (Location): 7p12.2; chr7:50303465-50405101 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants have a variety of T, B, and hematopoeitic cell maturation defects. Heterozygotes for one allele exhibit dominant negative effects and mice develop lymphoproliferative disorders.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Ikzf1 interacts with 348 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (52 annotations)
Process amacrine cell differentiation, B cell differentiation, ...
Component cytoplasm, nucleus, ...
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (32 records)
Data Summary: Results (279)    Tissues (169)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 232
RT-PCR 47
cDNA source data(68)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ikzf1 ; ZFIN ikzf1    NEW 
Molecular
reagents
All nucleic(78) Genomic(1) cDNA(68) Primer pair(8) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000005161 (Evidence)
Ensembl Gene Model ENSMUSG00000018654 (Evidence)
Entrez Gene 22778 (Evidence)
UniGene 103545
DFCI TC1780815, TC1598928, TC1607501, TC1592823, TC1586880
DoTS DT.91335562, DT.533411, DT.40185820, DT.110502155, DT.101300216, DT.110502148, DT.110502144, DT.110502137, DT.97370419, DT.94182616, DT.99841698
NIA Mouse Gene Index U012319
Consensus CDS Project CCDS24436.1, CCDS24437.1
International Mouse Phenotyping Consortium Status Ikzf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005161 VEGA Gene Model | MGI Sequence Detail 87110 C57BL/6J ±  kb
transcript OTTMUST00000011534 VEGA | MGI Sequence Detail 4697 Not Applicable 
polypeptide OTTMUSP00000005365 VEGA | MGI Sequence Detail 535 Not Applicable 

For the selected sequences
All sequences(130) RefSeq(56) UniProt(11)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(454 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000001811 DNA-binding protein Ikaros
References
(Earliest) J:12906 Georgopoulos K, et al., Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment. Science. 1992 Oct 30;258(5083):808-12
(Latest) J:219894 Mattar P, et al., A conserved regulatory logic controls temporal identity in mouse neural progenitors. Neuron. 2015 Feb 4;85(3):497-504
All references(155)
Other
accession IDs
MGD-MRK-11345, MGI:2442667, MGI:96535

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory