Ikzf1
Gene Detail

Symbol Name ID

Ikzf1 IKAROS family zinc finger 1 MGI:1342540

Synonyms

5832432G11Rik, Ikaros, LyF-1, Zfpn1a1

Feature Type

protein coding gene

Genetic Map

Chromosome 11

7.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr11:11685003-11772112 bp, + strand From VEGA annotation of GRCm38   87110 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55948  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ikaros-related zinc finger transcription factor
Gene Tree: Ikzf1

Human homologs

Human Homolog		IKZF1, IKAROS family zinc finger 1 (Ikaros)
NCBI Gene ID		10320
neXtProt AC		NX_Q13422
Human Synonyms		hIk-1, Hs.54452, IK1, IKAROS, LYF1, PRO0758, ZNFN1A1
Human Chr (Location)		7p13-p11.1

Alleles and phenotypes

All alleles(7) : Targeted(5) Gene trapped(1) Chemically induced(1)
 

Homozygous mutants have a variety of T, B, and hematopoeitic cell maturation defects. Heterozygotes for one allele exhibit dominant negative effects and mice develop lymphoproliferative disorders.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (39 annotations)

Process	B cell differentiation, cell cycle, ...
Component	centromeric heterochromatin, cytoplasm, ...
Function	DNA binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (27 records)
Data Summary: Results (279)    Tissues (169)    Images (34)
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 24, 28

Assay Type	Results
RNA in situ	232
RT-PCR	47

cDNA source data(70)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(80) Genomic(1) cDNA(70) Primer pair(8) Other(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000005161 (Evidence)
Ensembl Gene Model	ENSMUSG00000018654 (Evidence)
Entrez Gene	22778 (Evidence)
UniGene	103545
DFCI	TC1586880, TC1592823, TC1598928, TC1607501, TC1780815
DoTS	DT.101300216, DT.110502137, DT.110502144, DT.110502148, DT.110502155, DT.40185820, DT.533411, DT.91335562, DT.97370419, DT.99841698
NIA Mouse Gene Index	U012319
Consensus CDS Project	CCDS24436.1, CCDS24437.1
International Mouse Knockout Project Status	Ikzf1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005161	VEGA Gene Model | MGI Sequence Detail	87110	C57BL/6J
transcript	OTTMUST00000011534	VEGA | MGI Sequence Detail	4697	Not Applicable
polypeptide	OTTMUSP00000005365	VEGA | MGI Sequence Detail	535	Not Applicable

All sequences(77) RefSeq(4) UniProt(12)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(398 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology	PR:000001811	DNA-binding protein Ikaros

References

(Earliest) J:12906 Georgopoulos K, et al., Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment. Science. 1992 Oct 30;258(5083):808-12
(Latest) J:195863 Malinge S, et al., Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling. Blood. 2013 Mar 28;121(13):2440-51
All references(142)

Other accession IDs

MGD-MRK-11345, MGI:2442667, MGI:96535