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Ikzf1
Gene Detail
 Symbol
Name
ID
Ikzf1
IKAROS family zinc finger 1
MGI:1342540
Synonyms 5832432G11Rik, Ikaros, LyF-1, Zfpn1a1
Feature Type protein coding gene
Genetic Map
Chromosome 11
7.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:11685003-11772112 bp, + strand
From VEGA annotation of GRCm38

  87110 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55948  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ikaros-related zinc finger transcription factor
Gene Tree: Ikzf1

Human
homologs
Human Homolog IKZF1, IKAROS family zinc finger 1 (Ikaros)
NCBI Gene ID 10320
neXtProt AC  NX_Q13422
Human Synonyms  Hs.54452, IK1, IKAROS, LyF-1, LYF1, PPP1R92, PRO0758, ZNFN1A1
Human Chr (Location)  7p12.2; chr7:50304782-50405101 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants have a variety of T, B, and hematopoeitic cell maturation defects. Heterozygotes for one allele exhibit dominant negative effects and mice develop lymphoproliferative disorders.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Ikzf1 interacts with 349 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process B cell differentiation, cell cycle, ...
Component centromeric heterochromatin, cytoplasm, ...
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (30 records)
Data Summary: Results (279)    Tissues (169)    Images (34)
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 24, 28
Assay TypeResults
RNA in situ 232
RT-PCR 47
cDNA source data(68)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(78) Genomic(1) cDNA(68) Primer pair(8) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000005161 (Evidence)
Ensembl Gene ModelENSMUSG00000018654 (Evidence)
Entrez Gene22778 (Evidence)
UniGene103545
DFCITC1586880, TC1592823, TC1598928, TC1607501, TC1780815
DoTSDT.101300216, DT.110502137, DT.110502144, DT.110502148, DT.110502155, DT.40185820, DT.533411, DT.91335562, DT.97370419, DT.99841698
NIA Mouse Gene IndexU012319
Consensus CDS ProjectCCDS24436.1, CCDS24437.1
International Mouse Knockout Project StatusIkzf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005161 VEGA Gene Model | MGI Sequence Detail 87110 C57BL/6J ±  kb
transcript OTTMUST00000011534 VEGA | MGI Sequence Detail 4697 Not Applicable 
polypeptide OTTMUSP00000005365 VEGA | MGI Sequence Detail 535 Not Applicable 

For the selected sequences
All sequences(117) RefSeq(44) UniProt(12)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(454 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000001811 DNA-binding protein Ikaros
References (Earliest) J:12906 Georgopoulos K, et al., Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment. Science. 1992 Oct 30;258(5083):808-12
(Latest) J:208211 Schjerven H, et al., Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros. Nat Immunol. 2013 Oct;14(10):1073-83
All references(150)
Other
accession IDs
MGD-MRK-11345, MGI:2442667, MGI:96535

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory