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St6galnac1 Gene Detail
Summary
  • Symbol
    St6galnac1
  • Name
    ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
  • Synonyms
    Siat7a, ST6GalNAc I
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341826
    NCBI Gene: 20445
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr11:116655851-116666333 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 81.49 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    29 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341826
 protein coding gene Chr11:116655851-116666333 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019438
 protein coding gene Chr11:120920805-120940175 (-)
A/J MGP_AJ_G0019406
 protein coding gene Chr11:115598025-115607844 (-)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0019381
 protein coding gene Chr11:115990814-116000714 (-)
C3H/HeJ MGP_C3HHeJ_G0019187
 protein coding gene Chr11:119394906-119404430 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019830
 protein coding gene Chr11:124613221-124658453 (-)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0019158
 protein coding gene Chr11:129506070-129515441 (-)
DBA/2J MGP_DBA2J_G0019270
 protein coding gene Chr11:115020736-115030465 (-)
FVB/NJ MGP_FVBNJ_G0019262
 protein coding gene Chr11:114563989-114568043 (-)
LP/J MGP_LPJ_G0019340
 protein coding gene Chr11:121275238-121284607 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019295
 protein coding gene Chr11:128569114-128572538 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019869
 protein coding gene Chr11:119748223-119763879 (-)
PWK/PhJ MGP_PWKPhJ_G0018506
 protein coding gene Chr11:116353759-116363388 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018299
 protein coding gene Chr11:119478837-119504236 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    ST6GALNAC1, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ST6GALNAC1, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
  • Synonyms
    HSY11339, SIAT7A, ST6GalNAcI, STYI
  • Links
    NCBI Gene ID: 55808
    neXtProt AC: NX_Q9NSC7
    UniProt: Q9NSC7

  • Chr Location
    17q25.1; chr17:76617407-76643786 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with St6galnac1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
A specific missense mutation affects protein glycosylation in intestinal endothelial cells and leads to thinning of the colon inner mucus layer, increased microbial invasion of colon mucus and more severe DSS-induced colitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    813
  • Tissues
    107
  • cDNA Data
    4
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20445 NCBI Gene Model | MGI Sequence Detail 10483 C57BL/6J ±  kb
    transcript NM_011371 RefSeq | MGI Sequence Detail 2396 C57BL/6  
    polypeptide Q9QZ39 UniProt | EBI | MGI Sequence Detail 526 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 5
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 6
      Phenotypes 3
    • Earliest
      J:54623 Lee YC, et al., Molecular cloning and functional expression of two members of mouse NeuAcalpha2, 3 Galbeta1,3GalNAc GalNAcalpha2,6-sialyltransferase family, ST6GalNAc III and IV. J Biol Chem. 1999 Apr 23;274(17):11958-67
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory