Adam33
Gene Detail

Symbol Name ID

Adam33 a disintegrin and metallopeptidase domain 33 MGI:1341813

Feature Type

protein coding gene

Genetic Map

Chromosome 2

63.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr2:131050591-131063814 bp, - strand From VEGA annotation of GRCm38   13224 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:11881  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

Gene Tree: Adam33

Human homologs

Human Homolog		ADAM33, ADAM metallopeptidase domain 33
NCBI Gene ID		80332
neXtProt AC		NX_Q9BZ11
Human Synonyms		C20orf153, DJ964F7.1
Human Chr (Location)		20p13; chr20:3648620-3662738 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Mice homozygous for a targeted gene deletion are viable, fertile, developmentally normal and display normal allergen-induced airway hyperreactivity, IgE production, mucus metaplasia, and airway inflammation in an OVA-induced model of allergic asthma.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	integrin-mediated signaling pathway, metabolic process, ...
Component	integral to membrane, membrane
Function	hydrolase activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (38)    Tissues (24)    Images (4)
Theiler Stages: 13, 15, 20, 26, 28

Assay Type	Results
RNA in situ	3
Northern blot	11
RT-PCR	24

cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) Genomic(2) cDNA(20) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000015537 (Evidence)
Ensembl Gene Model	ENSMUSG00000027318 (Evidence)
Entrez Gene	110751 (Evidence)
UniGene	108550
DFCI	TC1586684, TC1596719, TC1606340, TC1635056, TC1685753, TC1779186
DoTS	DT.101734466, DT.110679831, DT.488543, DT.55276396, DT.91594498, DT.97361653
NIA Mouse Gene Index	U023374
EC	3.4.24.-
Consensus CDS Project	CCDS16753.1, CCDS50716.1
International Mouse Knockout Project Status	Adam33

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015537	VEGA Gene Model | MGI Sequence Detail	13224	C57BL/6J
transcript	OTTMUST00000036897	VEGA | MGI Sequence Detail	3165	Not Applicable
polypeptide	OTTMUSP00000016554	VEGA | MGI Sequence Detail	797	Not Applicable

All sequences(78) RefSeq(4) UniProt(8)

Polymorphisms

SNPs(173 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006586	ADAM, cysteine-rich
InterPro	IPR001762	Blood coagulation inhibitor, Disintegrin
InterPro	IPR018358	Disintegrin, conserved site
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR024079	Metallopeptidase, catalytic domain
InterPro	IPR001590	Peptidase M12B, ADAM/reprolysin
InterPro	IPR002870	Peptidase M12B, propeptide
Protein Ontology	PR:000032676	disintegrin and metalloproteinase domain-containing protein 33

References

(Earliest) J:53415 Gunn TM, et al., The mouse mahogany locus encodes a transmembrane form of human attractin. Nature. 1999 Mar 11;398(6723):152-6
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(39)