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Adam33
Gene Detail
Symbol

Name
ID
Adam33
a disintegrin and metallopeptidase domain 33
MGI:1341813
Feature Type
protein coding gene
Genetic Map
Chromosome 2
63.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:131050591-131063814 bp, - strand
From VEGA annotation of GRCm38

  13224 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11881  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ADAM33
Gene Tree: Adam33

Human
homologs
ADAM33, ADAM metallopeptidase domain 33
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 80332
neXtProt AC: NX_Q9BZ11

Human Synonyms: C20orf153, DJ964F7.1

Human Chr (Location): 20p13; chr20:3667973-3682131 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a targeted gene deletion are viable, fertile, developmentally normal and display normal allergen-induced airway hyperreactivity, IgE production, mucus metaplasia, and airway inflammation in an OVA-induced model of allergic asthma.
 
Interactions
Adam33 interacts with 76 markers (Mir23a, Mir23b, Mir125a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process proteolysis, regulation of cell proliferation, ...
Component integral component of membrane, membrane
Function hydrolase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (38)    Tissues (24)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 3
Northern blot 11
RT-PCR 24
cDNA source data(19)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ADAM33 ; Xenbase adam33    NEW 
Molecular
reagents
All nucleic(23) Genomic(2) cDNA(20) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000015537 (Evidence)
Ensembl Gene Model ENSMUSG00000027318 (Evidence)
Entrez Gene 110751 (Evidence)
UniGene 108550
DFCI TC1586684, TC1596719, TC1606340, TC1635056, TC1685753, TC1779186
DoTS DT.101734466, DT.110679831, DT.488543, DT.55276396, DT.91594498, DT.97361653
NIA Mouse Gene Index U023374
EC 3.4.24.-
Consensus CDS Project CCDS16753.1, CCDS50716.1
International Mouse Phenotyping Consortium Status Adam33
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015537 VEGA Gene Model | MGI Sequence Detail 13224 C57BL/6J ±  kb
transcript OTTMUST00000036897 VEGA | MGI Sequence Detail 3165 Not Applicable 
polypeptide OTTMUSP00000016554 VEGA | MGI Sequence Detail 797 Not Applicable 

For the selected sequences
All sequences(106) RefSeq(27) UniProt(9)
Polymorphisms
SNPs within 2kb(191 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006586 ADAM, cysteine-rich
InterPro IPR018358 Disintegrin, conserved site
InterPro IPR001762 Disintegrin domain
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 EGF-like domain
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR001590 Peptidase M12B, ADAM/reprolysin
InterPro IPR002870 Peptidase M12B, propeptide
Protein Ontology PR:000032676 disintegrin and metalloproteinase domain-containing protein 33
References
(Earliest) J:53415 Gunn TM, et al., The mouse mahogany locus encodes a transmembrane form of human attractin. Nature. 1999 Mar 11;398(6723):152-6
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(39)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory