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Adam33
Gene Detail
 Symbol
Name
ID
Adam33
a disintegrin and metallopeptidase domain 33
MGI:1341813
Feature Type protein coding gene
Genetic Map
Chromosome 2
63.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:131050591-131063814 bp, - strand
From VEGA annotation of GRCm38

  13224 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11881  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

Gene Tree: Adam33

Human
homologs
Human Homolog ADAM33, ADAM metallopeptidase domain 33
NCBI Gene ID 80332
neXtProt AC  NX_Q9BZ11
Human Synonyms  C20orf153, DJ964F7.1
Human Chr (Location)  20p13; chr20:3667973-3682131 (-)  GRCh38
Alleles
and
phenotypes
All alleles(7) : Targeted(7)
 
Mice homozygous for a targeted gene deletion are viable, fertile, developmentally normal and display normal allergen-induced airway hyperreactivity, IgE production, mucus metaplasia, and airway inflammation in an OVA-induced model of allergic asthma.
 
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process integrin-mediated signaling pathway, proteolysis, ...
Component integral component of membrane, membrane
Function hydrolase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (38)    Tissues (24)    Images (4)
Theiler Stages: 13, 15, 20, 26, 28
Assay TypeResults
RNA in situ 3
Northern blot 11
RT-PCR 24
cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(23) Genomic(2) cDNA(20) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000015537 (Evidence)
Ensembl Gene ModelENSMUSG00000027318 (Evidence)
Entrez Gene110751 (Evidence)
UniGene108550
DFCITC1586684, TC1596719, TC1606340, TC1635056, TC1685753, TC1779186
DoTSDT.101734466, DT.110679831, DT.488543, DT.55276396, DT.91594498, DT.97361653
NIA Mouse Gene IndexU023374
EC3.4.24.-
Consensus CDS ProjectCCDS16753.1, CCDS50716.1
International Mouse Knockout Project StatusAdam33
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015537 VEGA Gene Model | MGI Sequence Detail 13224 C57BL/6J ±  kb
transcript OTTMUST00000036897 VEGA | MGI Sequence Detail 3165 Not Applicable 
polypeptide OTTMUSP00000016554 VEGA | MGI Sequence Detail 797 Not Applicable 

For the selected sequences
All sequences(98) RefSeq(19) UniProt(9)
Polymorphisms SNPs within 2kb(191 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006586 ADAM, cysteine-rich
InterPro IPR001762 Blood coagulation inhibitor, Disintegrin
InterPro IPR018358 Disintegrin, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR001590 Peptidase M12B, ADAM/reprolysin
InterPro IPR002870 Peptidase M12B, propeptide
Protein Ontology PR:000032676 disintegrin and metalloproteinase domain-containing protein 33
References (Earliest) J:53415 Gunn TM, et al., The mouse mahogany locus encodes a transmembrane form of human attractin. Nature. 1999 Mar 11;398(6723):152-6
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(39)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory