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Ndrg1 Gene Detail
Summary
  • Symbol
    Ndrg1
  • Name
    N-myc downstream regulated gene 1
  • Synonyms
    CAP43, CMT4D, DRG1, Ndr1, Ndrl, PROXY1, Tdd5, TDD5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341799
    NCBI Gene: 17988
  • Gene Overview
    MyGene.info: NDRG1
Location & Maps
more
  • Sequence Map
    Chr15:66929321-66969640 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      40320 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 29.30 cM, cytoband D3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    NDRG1, N-myc downstream regulated 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NDRG1, N-myc downstream regulated 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAP43, CMT4D, DRG1, DRG-1, GC4, HMSNL, NDR1, NMSL, PROXY1, RIT42, RTP, TARG1, TDD5
  • Links
    NCBI Gene ID: 10397
    neXtProt AC: NX_Q92597

  • Chr Location
    8q24.3; chr8:133237171-133297587 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 55953
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: NDRG1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Ndrg1 mouse models; 1 with human NDRG1 associations

Human Disease Mouse Models
       Charcot-Marie-Tooth Disease, Type 4D; CMT4D   OMIM: 601455 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 3 alleles in 3 genetic backgrounds
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    3
  • Gene trapped
    1
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    6
  • Genomic Mutations
    5 involving Ndrg1
  • Incidental Mutations
Homozygous null mice exhibit a progressive demyelinating disorder of the peripheral nerves with hindlimb weakness. Mice homozygous for a different knock-out allele exhibit decreased cellular susceptibility to gamma-irradiation and increased susceptibility to spontaneous and induced tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035395 VEGA Gene Model | MGI Sequence Detail 40320 C57BL/6J ±  kb
transcript OTTMUST00000090506 VEGA | MGI Sequence Detail 2886 Not Applicable  
polypeptide OTTMUSP00000049672 VEGA | MGI Sequence Detail 394 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    427 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 536
    Genomic 1
    cDNA 533
    Primer pair 2

    Microarray probesets 7
Other
Accession IDs
less
MGI:1095397
References
more
  • Summaries
    All 66
    Developmental Gene Expression 20
    Diseases 2
    Gene Ontology 8
    Phenotypes 36
  • Earliest
    J:40331 Lin TM, et al., Cloning and characterization of TDD5, an androgen target gene that is differentially repressed by testosterone and dihydrotestosterone. Proc Natl Acad Sci U S A. 1997 May 13;94(10):4988-93
  • Latest
    J:230653 Grego-Bessa J, et al., The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium. Elife. 2016;5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory