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Ndrg1
Gene Detail
Symbol

Name
ID
Ndrg1
N-myc downstream regulated gene 1
MGI:1341799
Synonyms
CAP43, CMT4D, DRG1, Ndr1, Ndrl, PROXY1, Tdd5, TDD5
Feature Type
protein coding gene
Genetic Map
Chromosome 15
29.30 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:66929321-66969640 bp, - strand
From VEGA annotation of GRCm38

  40320 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55953  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ndrg1

Human
homologs
Human Homolog NDRG1, N-myc downstream regulated 1
NCBI Gene ID 10397
neXtProt AC  NX_Q92597
Human Synonyms  CAP43, CMT4D, DRG1, DRG-1, GC4, HMSNL, NDR1, NMSL, PROXY1, RIT42, RTP, TARG1, TDD5
Human Chr (Location)  8q24.3; chr8:133237171-133297304 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human NDRG1
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Radiation induced(1) Spontaneous(1) Targeted(5)
Genomic Mutations involving Ndrg1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit a progressive demyelinating disorder of the peripheral nerves with hindlimb weakness. Mice homozygous for a different knock-out allele exhibit decreased cellular susceptibility to gamma-irradiation and increased susceptibility to spontaneous and induced tumors.
 
Human Diseases Modeled Using Mouse Ndrg1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Ndrg1 interacts with 214 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process mast cell activation, peripheral nervous system myelin maintenance, ...
Component cell-cell adherens junction, centrosome, ...
Function cadherin binding, gamma-tubulin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (376)    Tissues (106)    Images (57)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 333
Northern blot 7
RT-PCR 36
cDNA source data(532)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(536) Genomic(1) cDNA(533) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000035395 (Evidence)
Ensembl Gene ModelENSMUSG00000005125 (Evidence)
Entrez Gene17988 (Evidence)
UniGene30837
DFCITC1573964
DoTSDT.97351556, DT.97364812, DT.97364778, DT.97364784
NIA Mouse Gene IndexU036245
Consensus CDS ProjectCCDS37092.1
International Mouse Knockout Project StatusNdrg1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035395 VEGA Gene Model | MGI Sequence Detail 40320 C57BL/6J ±  kb
transcript OTTMUST00000090506 VEGA | MGI Sequence Detail 2886 Not Applicable 
polypeptide OTTMUSP00000049672 VEGA | MGI Sequence Detail 394 Not Applicable 

For the selected sequences
All sequences(119) RefSeq(4) UniProt(29)
Polymorphisms
SNPs within 2kb(429 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004142 Ndr
Protein Ontology PR:000011059 protein NDRG1
References
(Earliest) J:40331 Lin TM, et al., Cloning and characterization of TDD5, an androgen target gene that is differentially repressed by testosterone and dihydrotestosterone. Proc Natl Acad Sci U S A. 1997 May 13;94(10):4988-93
(Latest) J:211289 Fantauzzo KA, et al., PI3K-mediated PDGFRalpha signaling regulates survival and proliferation in skeletal development through p53-dependent intracellular pathways. Genes Dev. 2014 May 1;28(9):1005-17
All references(61)
Disease annotation references (1)
Other
accession IDs
MGI:1095397

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory