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Ndrg1
Gene Detail
Symbol

Name
ID
Ndrg1
N-myc downstream regulated gene 1
MGI:1341799
Synonyms
CAP43, CMT4D, DRG1, Ndr1, Ndrl, PROXY1, Tdd5, TDD5
Feature Type
protein coding gene
Genetic Map
Chromosome 15
29.30 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:66929321-66969640 bp, - strand
From VEGA annotation of GRCm38

  40320 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55953  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NDRG1
Gene Tree: Ndrg1

Human
homologs
NDRG1, N-myc downstream regulated 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 10397
neXtProt AC: NX_Q92597

Human Synonyms: CAP43, CMT4D, DRG1, DRG-1, GC4, HMSNL, NDR1, NMSL, PROXY1, RIT42, RTP, TARG1, TDD5

Human Chr (Location): 8q24.3; chr8:133237171-133297587 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human NDRG1

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Radiation induced(1) Spontaneous(1) Targeted(5)
Genomic Mutations involving Ndrg1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit a progressive demyelinating disorder of the peripheral nerves with hindlimb weakness. Mice homozygous for a different knock-out allele exhibit decreased cellular susceptibility to gamma-irradiation and increased susceptibility to spontaneous and induced tumors.
 
Human Diseases Modeled in Mice Using Ndrg1 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Ndrg1 interacts with 213 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process mast cell activation, peripheral nervous system myelin maintenance, ...
Component cell-cell adherens junction, centrosome, ...
Function cadherin binding, gamma-tubulin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (376)    Tissues (106)    Images (57)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 333
Northern blot 7
RT-PCR 36
cDNA source data(532)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA NDRG1 ; Xenbase ndrg1 ; ZFIN ndrg1a, ndrg1b    NEW 
Molecular
reagents
All nucleic(536) Genomic(1) cDNA(533) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000035395 (Evidence)
Ensembl Gene Model ENSMUSG00000005125 (Evidence)
Entrez Gene 17988 (Evidence)
UniGene 30837
DFCI TC1573964
DoTS DT.97351556, DT.97364778, DT.97364784, DT.97364812
NIA Mouse Gene Index U036245
Consensus CDS Project CCDS37092.1
International Mouse Phenotyping Consortium Status Ndrg1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035395 VEGA Gene Model | MGI Sequence Detail 40320 C57BL/6J ±  kb
transcript OTTMUST00000090506 VEGA | MGI Sequence Detail 2886 Not Applicable 
polypeptide OTTMUSP00000049672 VEGA | MGI Sequence Detail 394 Not Applicable 

For the selected sequences
All sequences(103) RefSeq(2) UniProt(15)
Polymorphisms
SNPs within 2kb(429 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR029058 Alpha/Beta hydrolase fold
InterPro IPR004142 NDRG
InterPro IPR030693 Protein NDRG1
Protein Ontology PR:000011059 protein NDRG1
References
(Earliest) J:40331 Lin TM, et al., Cloning and characterization of TDD5, an androgen target gene that is differentially repressed by testosterone and dihydrotestosterone. Proc Natl Acad Sci U S A. 1997 May 13;94(10):4988-93
(Latest) J:215807 Heller BA, et al., Functionally distinct PI 3-kinase pathways regulate myelination in the peripheral nervous system. J Cell Biol. 2014 Mar 31;204(7):1219-36
All references(63)
Disease annotation references (1)
Other
accession IDs
MGI:1095397

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory