Ndrg1
Gene Detail

Symbol Name ID

Ndrg1 N-myc downstream regulated gene 1 MGI:1341799

Synonyms

CAP43, CMT4D, DRG1, Ndr1, Ndrl, PROXY1, Tdd5, TDD5

Feature Type

protein coding gene

Genetic Map

Chromosome 15

29.30 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr15:66929321-66969640 bp, - strand From VEGA annotation of GRCm38   40320 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55953  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ndrg1

Human homologs

Human Homolog		NDRG1, N-myc downstream regulated 1
NCBI Gene ID		10397
neXtProt AC		NX_Q92597
Human Synonyms		CAP43, CMT4D, DRG1, DRG-1, GC4, HMSNL, NDR1, NMSL, PROXY1, RIT42, RTP, TARG1, TDD5
Human Chr (Location)		8q24.3; chr8:134249414-134309547 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human NDRG1

Alleles and phenotypes

All alleles(7) : Targeted(5) Gene trapped(1) Spontaneous(1)
 

Homozygous null mice exhibit a progressive demyelinating disorder of the peripheral nerves with hindlimb weakness. Mice homozygous for a different knock-out allele exhibit decreased cellular susceptibility to gamma-irradiation and increased susceptibility to spontaneous and induced tumors.

 
Human Diseases Modeled Using Mouse Ndrg1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	mast cell activation, peripheral nervous system myelin maintenance, ...
Component	cell-cell adherens junction, centrosome, ...
Function	cadherin binding, gamma-tubulin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (15 records)
Data Summary: Results (375)    Tissues (101)    Images (56)
Theiler Stages: 2, 3, 7, 9, 11, 13, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	332
Northern blot	7
RT-PCR	36

cDNA source data(529)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(533) Genomic(1) cDNA(530) Primer pair(2)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000035395 (Evidence)
Ensembl Gene Model	ENSMUSG00000005125 (Evidence)
Entrez Gene	17988 (Evidence)
UniGene	30837
DFCI	TC1573964
DoTS	DT.97351556, DT.97364778, DT.97364784, DT.97364812
NIA Mouse Gene Index	U036245
Consensus CDS Project	CCDS37092.1
International Mouse Knockout Project Status	Ndrg1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035395	VEGA Gene Model | MGI Sequence Detail	40320	C57BL/6J
transcript	OTTMUST00000090506	VEGA | MGI Sequence Detail	2886	Not Applicable
polypeptide	OTTMUSP00000049672	VEGA | MGI Sequence Detail	394	Not Applicable

All sequences(103) RefSeq(2) UniProt(15)

Polymorphisms

SNPs(300 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004142	Ndr
Protein Ontology	PR:000011059	protein NDRG1

References

(Earliest) J:40331 Lin TM, et al., Cloning and characterization of TDD5, an androgen target gene that is differentially repressed by testosterone and dihydrotestosterone. Proc Natl Acad Sci U S A. 1997 May 13;94(10):4988-93
(Latest) J:184511 Cohen ED, et al., Wnt5a and Wnt11 are essential for second heart field progenitor development. Development. 2012 Jun;139(11):1931-40
All references(56)

Other accession IDs

MGI:1095397