Ndrg1^tm1Myta
Targeted Allele Detail

Summary

• Symbol: Ndrg1^tm1Myta
• Name: N-myc downstream regulated gene 1; targeted mutation 1, Toshiyuki Miyata
• MGI ID: MGI:3043362
• Synonyms: Ndrg1^-
• Gene: Ndrg1 Location: Chr15:66801167-66841489 bp, - strand Genetic Position: Chr15, 29.3 cM, cytoband D3
• Alliance: Ndrg1^tm1Myta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89888
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A single loxP site remained in place of a genomic fragment encompassing the promoter and exon 1 after cre-mediated excision of loxP sites inserted by homologus recombination. The start codon is contained within exon 2 and though neither transcript nor protein was detected in renal tissue via Northern or Western blot analysis, low levels of normal sized transcript and protein were detected in sciatic nerve. (J:89888)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ndrg1 Mutation: 27 strains or lines available

References

• Original: J:89888 Okuda T, et al., Ndrg1-deficient mice exhibit a progressive demyelinating disorder of peripheral nerves. Mol Cell Biol. 2004 May;24(9):3949-56
• All: 8 reference(s)