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Lrp8 Gene Detail
Summary
  • Symbol
    Lrp8
  • Name
    low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
  • Synonyms
    4932703M08Rik, apoER2, Lr8b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1340044
    NCBI Gene: 16975
Location & Maps
more
  • Sequence Map
    Chr4:107802261-107876840 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      74580 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 50.18 cM, cytoband C7
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    LRP8, LDL receptor related protein 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LRP8, LDL receptor related protein 8
    Orthology source: HGNC, HomoloGene
  • Synonyms
    APOER2, HSZ75190, LRP-8, MCI1
  • Links
    NCBI Gene ID: 7804
    neXtProt AC: NX_Q14114

  • Chr Location
    1p34; chr1:53242364-53328149 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 31250
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: LRP8
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human LRP8 associations

Human Disease Mouse Models
       Myocardial Infarction, Susceptibility to   OMIM: 608446
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 5 alleles in 4 genetic backgrounds
    26 phenotypes from multigenic genotypes
    1 images
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    2
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    7
  • Genomic Mutations
    4 involving Lrp8
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit impaired granule cell migration, radial glial scaffold formation, contextual fear conditioning, and long-term potentiation. Mutant males have abnormal sperm and are sterile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009153 VEGA Gene Model | MGI Sequence Detail 74580 C57BL/6J ±  kb
transcript OTTMUST00000020691 VEGA | MGI Sequence Detail 3291 Not Applicable  
polypeptide OTTMUSP00000032043 VEGA | MGI Sequence Detail 996 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    683 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000009928 low-density lipoprotein receptor-related protein 8
  • InterPro Domains
    IPR018097 EGF-like calcium-binding, conserved site
    IPR001881 EGF-like calcium-binding domain
    IPR013032 EGF-like, conserved site
    IPR000742 EGF-like domain
    IPR000152 EGF-type aspartate/asparagine hydroxylation site
    IPR000033 LDLR class B repeat
    IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
    IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
    IPR011042 Six-bladed beta-propeller, TolB-like
Molecular
Reagents
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  • All nucleic 49
    cDNA 48
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-35844, MGI:107377, MGI:2140379, MGI:2445098, MGI:3581522
References
more
  • Summaries
    All 117
    Developmental Gene Expression 34
    Gene Ontology 15
    Phenotypes 51
  • Earliest
    J:10174 Rollins BJ, et al., The human homolog of the JE gene encodes a monocyte secretory protein. Mol Cell Biol. 1989 Nov;9(11):4687-95
  • Latest
    J:221570 Telese F, et al., LRP8-Reelin-Regulated Neuronal Enhancer Signature Underlying Learning and Memory Formation. Neuron. 2015 May 6;86(3):696-710

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory