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Gene Detail
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Synonyms 4932703M08Rik, apoER2, Lr8b
Feature Type protein coding gene
Genetic Map
Chromosome 4
50.18 cM, cytoband C7
Detailed Genetic Map ± 1 cM

Mapping data(4)
Sequence Map
Chr4:107802261-107876840 bp, + strand
From VEGA annotation of GRCm38

  74580 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:31250  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Lrp8

Human Homolog LRP8, low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
NCBI Gene ID 7804
neXtProt AC  NX_Q14114
Human Synonyms  APOER2, HSZ75190, LRP-8, MCI1
Human Chr (Location)  1p34; chr1:53242364-53328149 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human LRP8
alleles, and
All mutations/alleles(8) : Gene trapped(2) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
Homozygotes for a targeted null mutation exhibit impaired granule cell migration, radial glial scaffold formation, contextual fear conditioning, and long-term potentiation. Mutant males have abnormal sperm and are sterile.
Phenotype Images(1)
Lrp8 interacts with 439 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
All GO classifications: (38 annotations)
Process ammon gyrus development, endocytosis, ...
Component axon, caveola, ...
Function apolipoprotein binding, calcium-dependent protein binding, ...
External Resources: FuncBase
Literature Summary: (30 records)
Data Summary: Results (47)    Tissues (31)    Images (3)
Theiler Stages: 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 44
Western blot 3
cDNA source data(46)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(49) cDNA(48) Other(1)
Microarray probesets(3)
Other database
VEGA Gene ModelOTTMUSG00000009153 (Evidence)
Ensembl Gene ModelENSMUSG00000028613 (Evidence)
Entrez Gene16975 (Evidence)
DFCITC1585592, TC1589051, TC1594091, TC1604732, TC1653599
DoTSDT.101363323, DT.482729, DT.526501, DT.91328865, DT.91431009
NIA Mouse Gene IndexU004608
Consensus CDS ProjectCCDS18439.1, CCDS51255.1
International Mouse Knockout Project StatusLrp8
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009153 VEGA Gene Model | MGI Sequence Detail 74580 C57BL/6J ±  kb
transcript OTTMUST00000020691 VEGA | MGI Sequence Detail 3291 Not Applicable 
polypeptide OTTMUSP00000032043 VEGA | MGI Sequence Detail 996 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(4) UniProt(6)
Polymorphisms SNPs within 2kb(685 from dbSNP Build 137)
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR000033 LDLR class B repeat
InterPro IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
InterPro IPR011042 Six-bladed beta-propeller, TolB-like
Protein Ontology PR:000009928 low-density lipoprotein receptor-related protein 8
References (Earliest) J:10174 Rollins BJ, et al., The human homolog of the JE gene encodes a monocyte secretory protein. Mol Cell Biol. 1989 Nov;9(11):4687-95
(Latest) J:212435 Kurokawa S, et al., Isoform-specific binding of selenoprotein P to the beta-propeller domain of apolipoprotein E receptor 2 mediates selenium supply. J Biol Chem. 2014 Mar 28;289(13):9195-207
All references(112)
accession IDs
MGD-MRK-35844, MGI:107377, MGI:2140379, MGI:2445098, MGI:3581522

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory