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Lrp8
Gene Detail
Symbol

Name
ID
Lrp8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MGI:1340044
Synonyms
4932703M08Rik, apoER2, Lr8b
Feature Type
protein coding gene
Genetic Map
Chromosome 4
50.18 cM, cytoband C7
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:107802261-107876840 bp, + strand
From VEGA annotation of GRCm38

  74580 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31250  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LRP8
Gene Tree: Lrp8

Human
homologs
LRP8, low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7804
neXtProt AC: NX_Q14114

Human Synonyms: APOER2, HSZ75190, LRP-8, MCI1

Human Chr (Location): 1p34; chr1:53242364-53328149 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LRP8

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(2) Targeted(7)
Genomic Mutations involving Lrp8 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit impaired granule cell migration, radial glial scaffold formation, contextual fear conditioning, and long-term potentiation. Mutant males have abnormal sperm and are sterile.
 
Phenotype Images(1)
Interactions
Lrp8 interacts with 438 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process ammon gyrus development, endocytosis, ...
Component axon, caveola, ...
Function apolipoprotein binding, calcium-dependent protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (34 records)
Data Summary: Results (47)    Tissues (31)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 44
Western blot 3
cDNA source data(46)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lrp8    NEW 
Molecular
reagents
All nucleic(49) cDNA(48) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000009153 (Evidence)
Ensembl Gene Model ENSMUSG00000028613 (Evidence)
Entrez Gene 16975 (Evidence)
UniGene 442134
DFCI TC1585592, TC1589051, TC1594091, TC1604732, TC1653599
DoTS DT.101363323, DT.482729, DT.526501, DT.91328865, DT.91431009
NIA Mouse Gene Index U004608
Consensus CDS Project CCDS18439.1, CCDS51255.1
International Mouse Phenotyping Consortium Status Lrp8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009153 VEGA Gene Model | MGI Sequence Detail 74580 C57BL/6J ±  kb
transcript OTTMUST00000020691 VEGA | MGI Sequence Detail 3291 Not Applicable 
polypeptide OTTMUSP00000032043 VEGA | MGI Sequence Detail 996 Not Applicable 

For the selected sequences
All sequences(100) RefSeq(32) UniProt(6)
Polymorphisms
SNPs within 2kb(685 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR001881 EGF-like calcium-binding domain
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 EGF-like domain
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000033 LDLR class B repeat
InterPro IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
InterPro IPR011042 Six-bladed beta-propeller, TolB-like
Protein Ontology PR:000009928 low-density lipoprotein receptor-related protein 8
References
(Earliest) J:10174 Rollins BJ, et al., The human homolog of the JE gene encodes a monocyte secretory protein. Mol Cell Biol. 1989 Nov;9(11):4687-95
(Latest) J:219839 Hirota Y, et al., Reelin receptors ApoER2 and VLDLR are expressed in distinct spatiotemporal patterns in developing mouse cerebral cortex. J Comp Neurol. 2015 Feb 15;523(3):463-78
All references(116)
Other
accession IDs
MGD-MRK-35844, MGI:107377, MGI:2140379, MGI:2445098, MGI:3581522

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory