Lrp8
Gene Detail

Symbol Name ID

Lrp8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor MGI:1340044

Synonyms

4932703M08Rik, apoER2, Lr8b

Feature Type

protein coding gene

Genetic Map

Chromosome 4

50.18 cM, cytoband C7
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr4:107802261-107876840 bp, + strand From VEGA annotation of GRCm38   74580 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31250  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Lrp8

Human homologs

Human Homolog		LRP8, low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
NCBI Gene ID		7804
neXtProt AC		NX_Q14114
Human Synonyms		APOER2, HSZ75190, LRP-8, MCI1
Human Chr (Location)		1p34; chr1:53708036-53793821 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human LRP8

Alleles and phenotypes

All alleles(8) : Targeted(6) Gene trapped(2)
 

Homozygotes for a targeted null mutation exhibit impaired granule cell migration, radial glial scaffold formation, contextual fear conditioning, and long-term potentiation. Mutant males have abnormal sperm and are sterile.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (34 annotations)

Process	ammon gyrus development, endocytosis, ...
Component	axon part, caveola, ...
Function	apolipoprotein binding, calcium-dependent protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (28 records)
Data Summary: Results (47)    Tissues (29)    Images (3)
Theiler Stages: 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	44
Western blot	3

cDNA source data(46)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(49) cDNA(48) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000009153 (Evidence)
Ensembl Gene Model	ENSMUSG00000028613 (Evidence)
Entrez Gene	16975 (Evidence)
UniGene	442134
DFCI	TC1585592, TC1589051, TC1594091, TC1604732, TC1653599
DoTS	DT.101363323, DT.482729, DT.526501, DT.91328865, DT.91431009
NIA Mouse Gene Index	U004608
Consensus CDS Project	CCDS18439.1, CCDS51255.1
International Mouse Knockout Project Status	Lrp8

Sequences

Length	Strain/Species
genomic	OTTMUSG00000009153	VEGA Gene Model | MGI Sequence Detail	74580	C57BL/6J
transcript	OTTMUST00000020691	VEGA | MGI Sequence Detail	3291	Not Applicable
polypeptide	OTTMUSP00000032043	VEGA | MGI Sequence Detail	996	Not Applicable

All sequences(72) RefSeq(4) UniProt(6)

Protein-related information

Resource	ID	Description
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR018097	EGF-like calcium-binding, conserved site
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000152	EGF-type aspartate/asparagine hydroxylation site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR009030	Growth factor, receptor
InterPro	IPR000033	LDLR class B repeat
InterPro	IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat
InterPro	IPR011042	Six-bladed beta-propeller, TolB-like
Protein Ontology	PR:000009928	low-density lipoprotein receptor-related protein 8

References

(Earliest) J:10174 Rollins BJ, et al., The human homolog of the JE gene encodes a monocyte secretory protein. Mol Cell Biol. 1989 Nov;9(11):4687-95
(Latest) J:181631 Gehman LT, et al., The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function. Genes Dev. 2012 Mar 1;26(5):445-60
All references(106)

Other accession IDs

MGD-MRK-35844, MGI:107377, MGI:2140379, MGI:2445098, MGI:3581522