Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables several functions, including amyloid-beta binding activity; apolipoprotein binding activity; and reelin receptor activity. Involved in several processes, including nervous system development; reelin-mediated signaling pathway; and regulation of dendrite development. Acts upstream of or within hippocampus development and layer formation in cerebral cortex. Located in cell surface and extracellular space. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density membrane. Is expressed in nervous system and retina layer. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; dementia; myocardial infarction; and schizophrenia. Orthologous to human LRP8 (LDL receptor related protein 8).