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Agtrap Gene Detail
Summary
  • Symbol
    Agtrap
  • Name
    angiotensin II, type I receptor-associated protein
  • Synonyms
    3300002E14Rik, Atrap, D4Wsu124e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339977
    NCBI Gene: 11610
  • Gene Overview
    MyGene.info: AGTRAP
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr4:148077061-148088031 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      10971 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 78.67 cM, cytoband E1
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    AGTRAP, angiotensin II receptor associated protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AGTRAP, angiotensin II receptor associated protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ATRAP
  • Links
    NCBI Gene ID: 57085
    neXtProt AC: NX_Q6RW13
    UniProt: Q6RW13

  • Chr Location
    1p36.22; chr1:11736085-11750771 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 7621
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: AGTRAP
  • Gene Tree
    Agtrap
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased mean systemic and systolic blood pressure, hypervolemia, decreased urine pH, and polyuria following administration of acetazolamide.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    32
  • Tissues
    21
  • cDNA Data
    48
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000010935 VEGA Gene Model | MGI Sequence Detail 10971 C57BL/6J ±  kb
    transcript OTTMUST00000025649 VEGA | MGI Sequence Detail 3996 Not Applicable  
    polypeptide OTTMUSP00000011755 VEGA | MGI Sequence Detail 161 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      212 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000003849 type-1 angiotensin II receptor-associated protein
      (term hierarchy)
    • InterPro Domains
      IPR009436 Type-1 angiotensin II receptor-associated protein
    Molecular
    Reagents
    less
    • All nucleic 51
      cDNA 48
      Primer pair 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-35796, MGI:107330, MGI:1922084
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
    • Latest
      J:264476 Azushima K, et al., Adipocyte-Specific Enhancement of Angiotensin II Type 1 Receptor-Associated Protein Ameliorates Diet-Induced Visceral Obesity and Insulin Resistance. J Am Heart Assoc. 2017 Mar 6;6(3)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/16/2018
    MGI 6.12     		The Jackson Laboratory