Agtrap
Gene Detail

Symbol

Name
ID

Agtrap
angiotensin II, type I receptor-associated protein
MGI:1339977

Synonyms

3300002E14Rik, Atrap, D4Wsu124e

Feature Type

protein coding gene

Genetic Map

Chromosome 4
78.67 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr4:148077061-148088031 bp, - strand From VEGA annotation of GRCm38   10971 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:7621  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Agtrap

Human
homologs

Human Homolog		AGTRAP, angiotensin II receptor-associated protein
NCBI Gene ID		57085
neXtProt AC		NX_Q6RW13
Human Synonyms		ATRAP
Human Chr (Location)		1p36.22; chr1:11736085-11750771 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(272) : Gene trapped(271) Targeted(1)
Genomic Mutations involving Agtrap (1)
 

Mice homozygous for a knock-out allele exhibit increased mean systemic and systolic blood pressure, hypervolemia, decreased urine pH, and polyuria following administration of acetazolamide.

 

Interactions

Agtrap interacts with 278 markers (Mir7-2, Mir7b, Mir10b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (14 annotations)

Process	angiotensin-activated signaling pathway, regulation of blood pressure
Component	cell cortex, cytoplasm, ...
Function	angiotensin type II receptor activity, protein binding

External Resources: FuncBase

Expression

Literature Summary: (3 records)

Data Summary: Results (11)    Tissues (6)    Images (2)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	5
RT-PCR	6

cDNA source data(47)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(48) cDNA(47) Primer pair(1)
Microarray probesets(6)

Other database
links

VEGA Gene Model	OTTMUSG00000010935 (Evidence)
Ensembl Gene Model	ENSMUSG00000029007 (Evidence)
Entrez Gene	11610 (Evidence)
UniGene	46247
DFCI	TC1602092, TC1580988
DoTS	DT.94130399, DT.488963
NIA Mouse Gene Index	U025783
Consensus CDS Project	CCDS18930.1
International Mouse Knockout Project Status	Agtrap

Sequences

Length	Strain/Species
genomic	OTTMUSG00000010935	VEGA Gene Model | MGI Sequence Detail	10971	C57BL/6J
transcript	OTTMUST00000025649	VEGA | MGI Sequence Detail	3996	Not Applicable
polypeptide	OTTMUSP00000011755	VEGA | MGI Sequence Detail	161	Not Applicable

All sequences(35) RefSeq(4) UniProt(1)

Polymorphisms

SNPs within 2kb(212 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR009436	Angiotensin II, type I receptor-associated
Protein Ontology	PR:000003849	type-1 angiotensin II receptor-associated protein

References

(Earliest) J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
(Latest) J:195457 Barro-Soria R, et al., Angiotensin-2-mediated Ca2+ signaling in the retinal pigment epithelium: role of angiotensin-receptor-associated-protein and TRPV2 channel. PLoS One. 2012;7(11):e49624
All references(44)

Other
accession IDs

MGD-MRK-35796, MGI:107330, MGI:1922084