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Agtrap Gene Detail
Summary
  • Symbol
    Agtrap
  • Name
    angiotensin II, type I receptor-associated protein
  • Synonyms
    3300002E14Rik, Atrap, D4Wsu124e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339977
    NCBI Gene: 11610
Location & Maps
more
  • Sequence Map
    Chr4:148077061-148088031 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10971 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    AGTRAP, angiotensin II receptor associated protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AGTRAP, angiotensin II receptor associated protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ATRAP
  • Links
    NCBI Gene ID: 57085
    neXtProt AC: NX_Q6RW13

  • Chr Location
    1p36.22; chr1:11735474-11750771 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7621
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: AGTRAP
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    273
  • Chemically induced (other)
    1
  • Gene trapped
    271
  • Targeted
    1
  • Genomic Mutations
    2 involving Agtrap
Mice homozygous for a knock-out allele exhibit increased mean systemic and systolic blood pressure, hypervolemia, decreased urine pH, and polyuria following administration of acetazolamide.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010935 VEGA Gene Model | MGI Sequence Detail 10971 C57BL/6J ±  kb
transcript OTTMUST00000025649 VEGA | MGI Sequence Detail 3996 Not Applicable  
polypeptide OTTMUSP00000011755 VEGA | MGI Sequence Detail 161 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    212 from dbSNP Build 137
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000003849 type-1 angiotensin II receptor-associated protein
  • InterPro Domains
    IPR009436 Angiotensin II, type I receptor-associated
Molecular
Reagents
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  • All nucleic 48
    cDNA 47
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-35796, MGI:107330, MGI:1922084
References
more
  • Summaries
    All 39
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
  • Latest
    J:195457 Barro-Soria R, et al., Angiotensin-2-mediated Ca2+ signaling in the retinal pigment epithelium: role of angiotensin-receptor-associated-protein and TRPV2 channel. PLoS One. 2012;7(11):e49624

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory