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Agtrap
Gene Detail
Symbol

Name
ID
Agtrap
angiotensin II, type I receptor-associated protein
MGI:1339977
Synonyms
3300002E14Rik, Atrap, D4Wsu124e
Feature Type
protein coding gene
Genetic Map
Chromosome 4
78.67 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:148077061-148088031 bp, - strand
From VEGA annotation of GRCm38

  10971 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7621  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: AGTRAP
Gene Tree: Agtrap

Human
homologs
AGTRAP, angiotensin II receptor-associated protein
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 57085
neXtProt AC: NX_Q6RW13

Human Synonyms: ATRAP

Human Chr (Location): 1p36.22; chr1:11735474-11750771 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(272) : Gene trapped(271) Targeted(1)
Genomic Mutations involving Agtrap (1)
 
Mice homozygous for a knock-out allele exhibit increased mean systemic and systolic blood pressure, hypervolemia, decreased urine pH, and polyuria following administration of acetazolamide.
 
Interactions
Agtrap interacts with 277 markers (Mir7-2, Mir7b, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process angiotensin-activated signaling pathway, regulation of blood pressure
Component cell cortex, cytoplasm, ...
Function angiotensin type II receptor activity, protein binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (11)    Tissues (6)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 5
RT-PCR 6
cDNA source data(47)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase agtrap    NEW 
Molecular
reagents
All nucleic(48) cDNA(47) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000010935 (Evidence)
Ensembl Gene Model ENSMUSG00000029007 (Evidence)
Entrez Gene 11610 (Evidence)
UniGene 46247
DFCI TC1602092, TC1580988
DoTS DT.488963, DT.94130399
NIA Mouse Gene Index U025783
Consensus CDS Project CCDS18930.1
International Mouse Phenotyping Consortium Status Agtrap
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010935 VEGA Gene Model | MGI Sequence Detail 10971 C57BL/6J ±  kb
transcript OTTMUST00000025649 VEGA | MGI Sequence Detail 3996 Not Applicable 
polypeptide OTTMUSP00000011755 VEGA | MGI Sequence Detail 161 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(212 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009436 Angiotensin II, type I receptor-associated
Protein Ontology PR:000003849 type-1 angiotensin II receptor-associated protein
References
(Earliest) J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
(Latest) J:195457 Barro-Soria R, et al., Angiotensin-2-mediated Ca2+ signaling in the retinal pigment epithelium: role of angiotensin-receptor-associated-protein and TRPV2 channel. PLoS One. 2012;7(11):e49624
All references(42)
Other
accession IDs
MGD-MRK-35796, MGI:107330, MGI:1922084

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory