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Agtrap Gene Detail
Summary
  • Symbol
    Agtrap
  • Name
    angiotensin II, type I receptor-associated protein
  • Synonyms
    3300002E14Rik, Atrap, D4Wsu124e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339977
    NCBI Gene: 11610
  • Gene Overview
    MyGene.info: AGTRAP
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:148077061-148088031 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 78.67 cM, cytoband E1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    212 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339977
 protein coding gene Chr4:148077061-148088064 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029116
 protein coding gene Chr4:151765118-151776021 (-)
A/J MGP_AJ_G0029081
 protein coding gene Chr4:145495247-145506522 (-)
AKR/J MGP_AKRJ_G0029029
 protein coding gene Chr4:149458760-149473566 (-)
BALB/cJ MGP_BALBcJ_G0029097
 protein coding gene Chr4:146006438-146017396 (-)
C3H/HeJ MGP_C3HHeJ_G0028818
 protein coding gene Chr4:150013752-150024793 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029546
 protein coding gene Chr4:157301483-157313061 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026792
 protein coding gene Chr4:137917095-137928089 (-)
CAST/EiJ MGP_CASTEiJ_G0028231
 protein coding gene Chr4:147204899-147220256 (-)
CBA/J MGP_CBAJ_G0028780
 protein coding gene Chr4:161814988-161828681 (-)
DBA/2J MGP_DBA2J_G0028928
 protein coding gene Chr4:145603167-145614576 (-)
FVB/NJ MGP_FVBNJ_G0028893
 protein coding gene Chr4:144689439-144701801 (-)
LP/J MGP_LPJ_G0029019
 protein coding gene Chr4:151724240-151737512 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028920
 protein coding gene Chr4:165192265-165204430 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029578
 protein coding gene Chr4:149936390-149947717 (-)
PWK/PhJ MGP_PWKPhJ_G0027951
 protein coding gene Chr4:141587049-141599088 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027785
 protein coding gene Chr4:144198335-144213517 (-)
WSB/EiJ MGP_WSBEiJ_G0028311
 protein coding gene Chr4:150089986-150102513 (-)



Homology
more
  • Human Ortholog
    AGTRAP, angiotensin II receptor associated protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AGTRAP, angiotensin II receptor associated protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ATRAP
  • Links
    NCBI Gene ID: 57085
    neXtProt AC: NX_Q6RW13
    UniProt: Q6RW13

  • Chr Location
    1p36.22; chr1:11736085-11750771 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 7621
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: AGTRAP
  • Gene Tree
    Agtrap
Human Diseases
more
  • Diseases
    1 with Agtrap mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele exhibit increased mean systemic and systolic blood pressure, hypervolemia, and decreased urine pH. Mice homozygous for a second null allele display normal blood pressure but abnormal adipose and insulin resistance on a high fat diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    663
  • Tissues
    21
  • cDNA Data
    48
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029007 Ensembl Gene Model | MGI Sequence Detail 10971 C57BL/6J ±  kb
    transcript ENSMUST00000030865 Ensembl | MGI Sequence Detail 3996 Not Applicable  
    polypeptide ENSMUSP00000030865 Ensembl | MGI Sequence Detail 161 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000003849 type-1 angiotensin II receptor-associated protein
      (term hierarchy)
    • InterPro Domains
      IPR009436 Type-1 angiotensin II receptor-associated protein
    Molecular
    Reagents
    less
    • All nucleic 51
      cDNA 48
      Primer pair 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-35796, MGI:107330, MGI:1922084
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 6
      Phenotypes 16
    • Earliest
      J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
    • Latest
      J:295832 Kinguchi S, et al., Effects of ATRAP in Renal Proximal Tubules on Angiotensin-Dependent Hypertension. J Am Heart Assoc. 2019 Apr 16;8(8):e012395
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    04/06/2021
    MGI 6.16     		The Jackson Laboratory