Agtrap MGI Mouse Gene Detail - MGI:1339977 - angiotensin II, type I receptor-associated protein

Agtrap Gene Detail

Symbol

Agtrap
Name

angiotensin II, type I receptor-associated protein
Synonyms

3300002E14Rik, Atrap, D4Wsu124e

Feature Type

protein coding gene
IDs

MGI:1339977
NCBI Gene: 11610
Gene Overview

MyGene.info: AGTRAP

Sequence Map

Chr4:148077061-148088031 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

10971 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 78.67 cM, cytoband E1
Mapping Data

4 experiments

Human Ortholog

AGTRAP, angiotensin II receptor associated protein

Vertebrate Orthologs

10

Human Ortholog

AGTRAP, angiotensin II receptor associated protein
Orthology source: HomoloGene, HGNC
Synonyms

ATRAP
Links

HGNC:13539

NCBI Gene ID: 57085

neXtProt AC: NX_Q6RW13

UniProt: Q6RW13
Chr Location

1p36.22; chr1:11736085-11750771 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 7621
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: AGTRAP
Gene Tree

Agtrap

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

272
Chemically induced (other)

1
Gene trapped

270
Targeted

1
Genomic Mutations

2 involving Agtrap
Find Mice (IMSR)

131 strains or lines available

Mice homozygous for a knock-out allele exhibit increased mean systemic and systolic blood pressure, hypervolemia, decreased urine pH, and polyuria following administration of acetazolamide.

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All GO Annotations

14
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

11
Tissues

6
cDNA Data

47
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA AGTRAP

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Agtrap interacts with 277 markers (Mir7-2, Mir7b, Mir10b, ...) View All

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All Sequences

33
RefSeq

6
UniProt

1
CCDS

CCDS18930.1
UniGene

46247

			Length	Strain/Species	Flank
genomic	OTTMUSG00000010935	VEGA Gene Model \| MGI Sequence Detail	10971	C57BL/6J	± kb
transcript	OTTMUST00000025649	VEGA \| MGI Sequence Detail	3996	Not Applicable
polypeptide	OTTMUSP00000011755	VEGA \| MGI Sequence Detail	161	Not Applicable

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SNPs within 2kb

212 from dbSNP Build 142

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UniProt

1 Sequence
Protein Ontology

PR:000003849 type-1 angiotensin II receptor-associated protein

(term hierarchy)
InterPro Domains

IPR009436 Type-1 angiotensin II receptor-associated protein

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All nucleic 48

cDNA 47

Primer pair 1

Microarray probesets 6

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MGD-MRK-35796, MGI:107330, MGI:1922084

Summaries

All 44

Developmental Gene Expression 4

Gene Ontology 6

Phenotypes 11
Earliest

J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
Latest

J:240319 Stauber M, et al., Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Dev Biol. 2017 Mar 15;423(2):170-188

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 09/12/2017 MGI 6.10